BLBC0211p Biochemistry - lecture

Faculty of Medicine
spring 2023
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
Mgr. Marie Tomandlová, Ph.D. (lecturer)
Marcela Nečasová (assistant)
Bc. Ivana Ševčíková (assistant)
RNDr. Hana Paulová, CSc. (alternate examiner)
Mgr. Jiří Slanina, Ph.D. (alternate examiner)
prof. RNDr. Eva Táborská, CSc. (alternate examiner)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Wed 15. 2. 8:00–9:50 B11/234, Wed 22. 2. 8:00–9:50 B11/234, Wed 1. 3. 8:00–9:50 B11/234, Wed 8. 3. 8:00–9:50 B11/234, Wed 15. 3. 8:00–9:50 B11/234, Wed 22. 3. 8:00–9:50 B11/234, Wed 29. 3. 8:00–9:50 B11/234, Wed 5. 4. 8:00–9:50 B11/234, Wed 12. 4. 8:00–9:50 B11/234, Wed 19. 4. 8:00–9:50 B11/234, Wed 26. 4. 8:00–9:50 B11/234, Wed 3. 5. 8:00–9:50 B11/234, Wed 10. 5. 8:00–9:50 B11/234, Wed 17. 5. 8:00–9:50 B11/234, Wed 24. 5. 8:00–9:50 B11/234
Prerequisites (in Czech)
BLLC0111s Medical Chemistry - seminar && BLLC0111c Medical Chemistry - practice
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to obtain knowledge on essential metabolic processes on the cell level.
Learning outcomes
After completing the course, the student gains basic knowledge about:
- enzyme function and factors influencing enzyme reactions;
- metabolic pathways of carbohydrates, lipids and proteins;
- cellular bioenergetics;
- composition and properties of cell membranes and transport systems across membranes;
- proteosynthesis and types of posttranslational modifications;
- structure and function of proteins;
- structure and function of hemoglobin.
Syllabus
  • Enzymes, properties, classification, quantification, kinetics. Factors influencing the speed of enzyme reactions.
  • Enzyme cofactors. Introduction to Metabolism. Macroergic compounds.
  • Three phases of nutrient catabolism. Citrate cycle. Respiratory chain. Oxidative phosphorylation. Reactive oxygen species, antioxidants.
  • Digestion of carbohydrates. Introduction to Carbohydrate Metabolism. Glycolysis. Gluconeogenesis. Synthesis and breakdown of glycogen.
  • Pentose cycle. Metabolism of fructose and galactose. Mutual transformations of carbohydrates in the cell, formation of carbohydrate derivatives.
  • Protein digestion and intracellular degradation.
  • General mechanisms of biodegradation of amino acids. Ammonia detoxification and transport. Metabolism of individual amino acids.
  • Digestion of lipids. Fatty acid metabolism. Ketogenesis and ketolysis. Metabolism of triacylglycerols. Metabolism of phospholipids and glycolipids. Eicosanoids. Metabolism of cholesterol and bile acids.
  • Synthesis and degradation of heme. Hemoglobin.
  • Metabolism of nucleotides and their bases. DNA replication.
  • DNA transcription. Regulation of gene expression.
  • Proteosynthesis, post-translational modifications.
Literature
    required literature
  • LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny. 3. vydání. Praha: Univerzita Karlova, nakladatelství Karolinum, 2020, 269 stran. ISBN 9788024647487. info
  • Studijní podklady a materiály k předmětu dostupné v IS MUNI.
    recommended literature
  • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017, viii, 567. ISBN 9781496363541. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Grada. Praha, 2012, 498 pp. ISBN 978-80-247-2977-0. info
  • MATOUŠ, Bohuslav. Základy lékařské chemie a biochemie. 1. vyd. Praha: Galén, 2010, xv, 540. ISBN 9788072627028. info
Teaching methods
Lectures.
Assessment methods
Oral examination.
Student draws a total of three questions. Student answers questions without preparation.
Language of instruction
Czech
Further comments (probably available only in Czech)
Information on completion of the course: přistoupení ke zkoušce je podmíněno úspěšným ukončením předmětů BLLC0111p, BLBC0211s a BLBC0211c.
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2024, spring 2025.
  • Enrolment Statistics (spring 2023, recent)
  • Permalink: https://is.muni.cz/course/med/spring2023/BLBC0211p