DSMBz01 Molecular Biology and Genetics

Faculty of Medicine
spring 2020
Extent and Intensity
0/0/0. 5 credit(s). Recommended Type of Completion: k (colloquium). Other types of completion: zk (examination).
Teacher(s)
prof. Ing. Petr Dvořák, CSc. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
doc. Mgr. Lumír Krejčí, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
doc. RNDr. Alena Hyršlová Vaculová, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
Mgr. Michaela Bosáková, Ph.D. (lecturer)
Nicola Silva, PhD. (lecturer)
prof. RNDr. Ondřej Slabý, Ph.D. (lecturer)
Mgr. Dominika Hobzová (assistant)
Guaranteed by
prof. RNDr. Ondřej Slabý, Ph.D.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Dominika Hobzová
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 45 student(s).
Current registration and enrolment status: enrolled: 8/45, only registered: 0/45, only registered with preference (fields directly associated with the programme): 0/45
fields of study / plans the course is directly associated with
there are 112 fields of study the course is directly associated with, display
Course objectives
The course covers an overview of new and modern methods involved in molecular and cell biology research. It covers mainly molecular biology (regulation of gene expression, human genome, gene therapy, and cell biology (stem cells and cell therapy, cytoskeleton and molecular motors, cell cycle, apoptosis and malignant cell transformation). This information will help to better understand to new scientific topics in biology.
Syllabus
  • Molecular biology and genetics. DNA, structure, RNA structure, Proteins, structure, experimental methods. Allosteric proteins. DNA replication. RNA synthesis, transcription. protein synthesis, function of ribosome, posttranslational modifications. Inhibitors of DNA and RNA synthesis. Genetic information. Regulation of gene expression. Genetic recombination. Human genome. Genetic engineering. Molecular diagnostics of non-functional genes. Membrane structure. Cell signaling. Cytoskeleton. cell cycle. Structure of cell nucleus. Chromosome structure. Mitosis. Meiosis. Molecular principles of cell movement. gametes and fertilization. Differentiation and dedifferentiation. Apoptosis. Biology of stem cells. Applications of stem cells in medicine. Malignant cell transformation. Oncogenes, carcinoma suppressors.
Literature
    recommended literature
  • ALBERTS, B. et al.: Molecular biology of the cell, 4.vyd.Garland Publ.Inc., New York, 2002
  • ALBERTS, B. et al.: Essential cell biology, 2.vyd., Garland Publ.Inc., New York, 2004
  • BECKER,W.M. et al.: The world of the cell. 7.vyd., Benjamin Cummins Publ. Comp. New York, 2008
  • CLARK, D.P. et al., Molecular biology, Elsevier, Inc. Amsterdam – Tokyo
  • FILIP, S. et al., Kmenové buňky – biologie, medicína, filozofie, Galén Praha, 2006
  • LODISH, et al.: Molecular cell biology, 4.ed., W.H. Freeman and Company, New York, 2001
  • POLLARD,T.D., et al.: Cell Biology. Saunders, New York, 2008
  • STRACHAN, T.,READ, A.P.: Human Molecular Genetics.Bios Scientific Publishers Ltd., Oxford, 1997
  • WEINBERG, R.A.: The Biology of Cancer. Garland Science Publishing, New York, 2006
  • WOLPERT, L.et al.: Principles of development. Oxford University Press, Oxford, 2002
  • Cell death. Edited by Gerry Melino - David Vaux. 1st pub. Hoboken, NJ: Wiley-Blackwell, 2010, xi, 303. ISBN 9780470715734. info
  • ALLISON, Lizabeth A. Fundamental molecular biology. 2nd ed. Hoboken: Wiley-Blackwell, 2011, xxvi, 696. ISBN 9780470550748. info
  • Šárka Pospíšilová, Dana Dvořáková, Jiří Mayer, et al. Molekulární hematologie
Teaching methods
Přednášky se budou konat https://is.muni.cz/auth/predmety/?fakulta=1411;obdobi=7483;predmet=1233105;pvysl=521926620.3.2020 a 27.3.2020 vždy od 09:00-14:00 nebo 15:10, místnost 1.17, pavilon A3 (Biologický ústav), Univerzitní kampus Brno Bohunice
20. března 2020
09:00 – 10:00 Stem Cells, prof. P. Dvořák (presentation uploadedd to study material)
10:10 – 11:10 ......., Dr. Nicola Silva
11:20 – 12:20 Potential of molecular biology and genetics methods for medicine, Doc.Slaninova (presentation uploaded)
13:00 – 14:00 Human Genome: new findings and applications, Prof. David Šmajs (presentation uploaded)

27. března 2020
09:00 – 10:00 Human diseases‘ cellular models, Dr. Vladimír Rotrekl
11:20 – 12:20 Cell signaling in differentiation, Dr. Pavel Krejčí
13:00 – 14:00 Malignant transformation of a cell, Dr. Stjepan Uldrijan
14:10 - 15:10 Molecular mechanism of DNA repair, Doc. Lumír Krejčí (presentation uploaded)
Assessment methods
Lesson attendance is mandatory (2 blocks).
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
The course is taught: in blocks.
Information on the extent and intensity of the course: 8.
Information on course enrolment limitations: Předmět je přednostně určen pro postgraduální studenty
The course is also listed under the following terms Spring 2000, Spring 2001, Autumn 2001, Spring 2002, Autumn 2002, Spring 2003, Autumn 2003, Spring 2004, Autumn 2004, Spring 2005, Autumn 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (spring 2020, recent)
  • Permalink: https://is.muni.cz/course/med/spring2020/DSMBz01