DSMBz01 Advances in Molecular Biology and Genetics

Faculty of Medicine
spring 2022
Extent and Intensity
0/0/0. 5 credit(s). Recommended Type of Completion: k (colloquium). Other types of completion: zk (examination).
Teacher(s)
prof. RNDr. Ondřej Slabý, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
RNDr. Pavel Krejčí, Ph.D. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Mgr. Stjepan Uldrijan, CSc. (lecturer)
doc. RNDr. Alena Hyršlová Vaculová, Ph.D. (lecturer)
Mgr. Vladimír Rotrekl, Ph.D. (lecturer)
Mgr. Michaela Bosáková, Ph.D. (lecturer)
Nicola Silva, PhD. (lecturer)
Mgr. Monika Stanková, Ph.D. (assistant)
Mgr. Barbora Valčíková (assistant)
Guaranteed by
prof. RNDr. Ondřej Slabý, Ph.D.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Barbora Valčíková
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 45 student(s).
Current registration and enrolment status: enrolled: 21/45, only registered: 0/45, only registered with preference (fields directly associated with the programme): 0/45
fields of study / plans the course is directly associated with
there are 112 fields of study the course is directly associated with, display
Course objectives
The course covers an overview of current topics in molecular biology and genetics (DNA damage and repair, cell death, genome stability) and cell biology (cancer biology, infectious diseases, stem cells, cell signalling. This course will help to better understand the new directions in biology research.
Syllabus
  • Stem cells in medicine. Apoptosis. Necrosis. Autophagy. Cell cycle, CDK, CDK inhibitors. Cell death. Cytoskeleton and molecular machineries. Differenciation. DNA and RNA, structure, methods. Gene expression and its regulation. Genetic iniformation, gene. Gene therapy. Gene engineering. Human genome. Mitosis. Mitosis. DNA rapair. Molecular mechanisms of cell motion. Molecular therapy. Malignant transofrmation of cell. Oncogenes, tumor supressors. Personalized medicine. Structure of nucleus. Structure of eukaryotic chromosome. Vesicular transport. Secretion and endodytosis.
Literature
    recommended literature
  • ALBERTS, B. et al.: Molecular biology of the cell, 4.vyd.Garland Publ.Inc., New York, 2002
  • ALBERTS, B. et al.: Essential cell biology, 2.vyd., Garland Publ.Inc., New York, 2004
  • BECKER,W.M. et al.: The world of the cell. 7.vyd., Benjamin Cummins Publ. Comp. New York, 2008
  • CLARK, D.P. et al., Molecular biology, Elsevier, Inc. Amsterdam – Tokyo
  • FILIP, S. et al., Kmenové buňky – biologie, medicína, filozofie, Galén Praha, 2006
  • LODISH, et al.: Molecular cell biology, 4.ed., W.H. Freeman and Company, New York, 2001
  • POLLARD,T.D., et al.: Cell Biology. Saunders, New York, 2008
  • STRACHAN, T.,READ, A.P.: Human Molecular Genetics.Bios Scientific Publishers Ltd., Oxford, 1997
  • WEINBERG, R.A.: The Biology of Cancer. Garland Science Publishing, New York, 2006
  • WOLPERT, L.et al.: Principles of development. Oxford University Press, Oxford, 2002
  • Cell death. Edited by Gerry Melino - David Vaux. 1st pub. Hoboken, NJ: Wiley-Blackwell, 2010, xi, 303. ISBN 9780470715734. info
  • ALLISON, Lizabeth A. Fundamental molecular biology. 2nd ed. Hoboken: Wiley-Blackwell, 2011, xxvi, 696. ISBN 9780470550748. info
  • Šárka Pospíšilová, Dana Dvořáková, Jiří Mayer, et al. Molekulární hematologie
Teaching methods
The lectures will be held on 01.04.2022 a 08.04.2022 in room 117, building C03.

01.04.2022
09:00 – 10:00 Introduction to Cancer Biology, Dr. Stjepan Uldrijan
10:10 – 11:10 Precision Oncology, Prof. Ondřej Slabý
11:20 – 12:20 Eradication of Infectious Diseases: the WHO Yaws Programme, Prof. David Šmajs
13:00 – 14:00 Apoptosis in health and disease, doc. Alena Hyršlová Vaculová

08.04.2022
09:00 - 10:00 Potential of molecular biology and genetics methods for medicine, Prof. Iva Slaninová
10:10 - 11:20 Stem cell disease model, Dr. Vladimír Rotrekl
11:20 – 12:20 Cell communication via growth factors, Dr. Pavel Krejčí
13:00 – 14:00 The cilia kinases in human skeletogenesis, Dr. Michaela Bosáková
Assessment methods
Block of lectures (2 blocks). The attandace is mandatory.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
The course is taught: in blocks.
Note related to how often the course is taught: 1. 4. 2022, 8. 4. 2022.
Information on the extent and intensity of the course: 8.
Information on course enrolment limitations: Předmět je přednostně určen pro postgraduální studenty
The course is also listed under the following terms Spring 2000, Spring 2001, Autumn 2001, Spring 2002, Autumn 2002, Spring 2003, Autumn 2003, Spring 2004, Autumn 2004, Spring 2005, Autumn 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (spring 2022, recent)
  • Permalink: https://is.muni.cz/course/med/spring2022/DSMBz01