BLBC0211s Biochemistry - seminar

Faculty of Medicine
spring 2021
Extent and Intensity
0/2/0. 1 credit(s). Type of Completion: z (credit).
Teacher(s)
Mgr. Marie Tomandlová, Ph.D. (seminar tutor)
Mgr. Jindra Smutná, Ph.D. (seminar tutor)
doc. RNDr. Josef Tomandl, Ph.D. (seminar tutor)
Mgr. Martina Drabinová (assistant)
Mgr. David Galuška (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
doc. RNDr. Jiří Dostál, CSc. (alternate examiner)
RNDr. Hana Paulová, CSc. (alternate examiner)
Mgr. Jiří Slanina, Ph.D. (alternate examiner)
prof. RNDr. Eva Táborská, CSc. (alternate examiner)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Fri 5. 3. 8:00–9:40 A16/215, Fri 12. 3. 8:00–9:40 A16/215, Fri 19. 3. 8:00–9:40 A16/215, Fri 26. 3. 8:00–9:40 A16/215, Fri 9. 4. 8:00–9:40 A16/215, Fri 16. 4. 8:00–9:40 A16/215, Fri 23. 4. 8:00–9:40 A16/215, Fri 30. 4. 8:00–9:40 A16/215, Fri 7. 5. 8:00–9:40 A16/215, Fri 14. 5. 8:00–9:40 A16/215, Fri 21. 5. 8:00–9:40 A16/215, Fri 28. 5. 8:00–9:40 A16/215, Fri 4. 6. 8:00–9:40 A16/215, Fri 11. 6. 8:00–9:40 A16/215
Prerequisites (in Czech)
BLLC0111s Med.Chem.-seminar && BLLC0111c Medical Chemistry -p
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to practice the basic metabolic processes taking place at the cellular level.
Learning outcomes
In the end of the course will students:
- understand the properties and function of enzymes
- describes basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism
- understand the principles of energy production, utilization and deposition at the cellular level
- explain the function of cell membranes and the transport processes on the membrane
- describe protein synthesis, understand the relationship between protein structure and function
- explain the function of hemoglobin in oxygen transport and maintaining acid-base balance
Syllabus
  • Introduction into the metabolism of cells. Membrane structure and assembly. Transport across membranes.
  • Enzymes - reaction rate, progress curve, the Michaelis plot and Km, enzyme inhibition.
  • Coenzymes, their relationship to vitamins.
  • The citric acid cycle.
  • The respiratory chain and oxidative phosphorylation.
  • Metabolism of glucose: Glycolysis under anaerobic and aerobic conditions and the oxidation of pyruvate.
  • Gluconeogenesis. Glycogenesis and glycogenolysis.
  • Metabolism of proteins. Common features of amino acid conversion. The synthesis of urea. Nitrogen balance.
  • Important reactions in amino acid catabolism.
  • Biosynthesis and desaturation of fatty acids. The sources of essential fatty acids. Metabolism of triacylglycerols.
  • Metabolism of lipids. Biosynthesis of eicosanoids. Peroxidation of lipids.
  • Metabolism of heam. Hemoglobin.
  • Biosynthesis and catabolism of purine and pyrimidine nucleotides.
Literature
    required literature
  • Podklady k seminářům dostupné v Informačním systému
    recommended literature
  • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017, viii, 567. ISBN 9781496363541. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. 1st ed. Praha: Grada, 2012, 498 pp. ISBN 978-80-247-2977-0. info
  • MATOUŠ, Bohuslav. Základy lékařské chemie a biochemie. 1. vyd. Praha: Galén, 2010, xv, 540. ISBN 9788072627028. info
  • LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny, I. a II. díl. Druhé vydání. Praha: Karolinum, 2009, 546 pp. ISBN 978-80-246-1414-4. info
Teaching methods
Course is based on group discusion to the given topics. Complementary materials are available in section Study materials.
Assessment methods
Course-unit credit. Conditions for giving the course-unit credit:
  • Insertion of all files with control questions and filled in answers into the Homework vaults Office in IS MUNI in the corresponding terms.
  • Completion of all seminars, substitution of all missed seminars according to the teacher's instructions.
  • Achievement of 70% success rate in continuous tests or 50% success rate in the final test; a final test can be repeated only once.
    • Language of instruction
    Czech
    Further comments (probably available only in Czech)
    The course is taught annually.
    General note: Úspěšné ukončení předmětu je předpokladem pro přistoupení ke zkoušce v předmětu BLBC0211p.
    Information on the extent and intensity of the course: 30.
    Listed among pre-requisites of other courses
    Teacher's information
    A list of all laboratory practice topics is post up on notice board of Department of Biochemistry and on IS MUNI - Study materials - Course-related instructions.

    Consultations are possible after personal arrangement with the teacher.

    The course is also listed under the following terms Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2022, spring 2023, spring 2024, spring 2025.
    • Enrolment Statistics (spring 2021, recent)
    • Permalink: https://is.muni.cz/course/med/spring2021/BLBC0211s