ZLFA0621c Pharmacology I - practice

Faculty of Medicine
spring 2023
Extent and Intensity
0/2/0. 2 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
Mgr. Petra Amchová, Ph.D. (seminar tutor)
PharmDr. Adéla Bártová (seminar tutor)
MVDr. Eva Dražanová, Ph.D. (seminar tutor)
PharmDr. Tomáš Hammer (seminar tutor)
PharmDr. Mária Hricková (seminar tutor)
Mgr. Petr John (seminar tutor)
Mgr. Jana Kubátová, Ph.D. (seminar tutor)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (seminar tutor)
MUDr. Alena Máchalová, Ph.D. (seminar tutor)
Mgr. Kristýna Nosková, Ph.D. (seminar tutor)
MUDr. Jana Pistovčáková, Ph.D. (seminar tutor)
PharmDr. Jitka Rychlíčková, Ph.D. (seminar tutor)
PharmDr. Lenka Součková, Ph.D. (seminar tutor)
Mgr. Zuzana Strašilová (seminar tutor)
MUDr. Filip Šiška (seminar tutor)
Renata Bláblová (assistant)
Mgr. Marta Vyoralová (assistant)
doc. RNDr. Ladislava Bartošová, Ph.D. (alternate examiner)
doc. PharmDr. Jan Juřica, Ph.D. (alternate examiner)
Mgr. Barbora Říhová, Ph.D. (alternate examiner)
doc. PharmDr. Ondřej Zendulka, Ph.D. (alternate examiner)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. MUDr. Regina Demlová, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Timetable of Seminar Groups
ZLFA0621c/21: Mon 20. 3. 9:30–12:00 A19/326, Tue 21. 3. 9:30–12:00 A19/326, Wed 22. 3. 9:30–12:00 A19/326, Thu 23. 3. 9:30–12:00 A19/326, Fri 24. 3. 9:30–12:00 A19/326, Tue 11. 4. 9:30–12:00 A19/326, Wed 12. 4. 9:30–12:00 A19/326, Thu 13. 4. 9:30–12:00 A19/326, Fri 14. 4. 9:30–12:00 A19/326
ZLFA0621c/22: Mon 27. 3. 9:30–12:00 A19/326, Tue 28. 3. 9:30–12:00 A19/326, Wed 29. 3. 9:30–12:00 A19/326, Thu 30. 3. 9:30–12:00 A19/326, Fri 31. 3. 9:30–12:00 A19/326, Tue 9. 5. 9:30–12:00 A19/326, Wed 10. 5. 9:30–12:00 A19/326, Fri 12. 5. 9:30–12:00 A19/326
ZLFA0621c/23: Mon 24. 4. 9:30–12:00 A19/326, Tue 25. 4. 9:30–12:00 A19/326, Wed 26. 4. 9:30–12:00 A19/326, Thu 27. 4. 9:30–12:00 A19/326, Fri 28. 4. 9:30–12:00 A19/326, Tue 2. 5. 9:30–12:00 A19/326, Wed 3. 5. 9:30–12:00 A19/326, Thu 4. 5. 9:30–12:00 A19/326, Fri 5. 5. 9:30–12:00 A19/326
Prerequisites (in Czech)
ZLPA0521c Pathology I - practice && ZLPF0521c Pathophysiol.I - practice && ZLCP051c Clin. Exam. in Surgery-pract.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
On completion of the course the student will be able to use formally correct terminology belonging to the valid Pharmacopoea in prescription and making of drug dosage forms of both individually prepared and bulk preparations. The student should be able to understand principles of "pharmacological thinking" for choosing a drug, dosing regimen, pharmacokinetic parameter calculation, differences in administration routes and specifics of pediatric and geriatric pharmacotherapy including possible impact of drug-drug interactions.
Learning outcomes
On completion of the course the student will be able to use formally correct terminology belonging to the valid Pharmacopoea in prescription and making of drug dosage forms of both individually prepared and bulk preparations. The student should be able to understand principles of "pharmacological thinking" for choosing a drug, dosing regimen, pharmacokinetic parameter calculation, differences in administration routes and specifics of pediatric and geriatric pharmacotherapy including possible impact of drug-drug interactions.
Syllabus

  • Pharmacology - practical courses

    Dentistry

    Spring semester 2023

    1st week
  • /1/ MONDAY
  • INTRODUCTION TO THE STUDY OF PHARMACOLOGY
  • Contents of the study of Pharmacology, contents and organization of theoretical and practical courses and lectures, required and recommended textbooks. The conditions for granting the credit. Pharmacology - definition, basic terminology, subspecializations, drug nomenclature. Introduction to the prescription terminology. Classification of drug preparations. Pharmacopoeia, Pharmacopoeia Bohemica. Basic calculations in pharmacology. Provisions of narcotic and psychotropic substances.
  • /2/ TUESDAY
  • APPLIED PHARMACOKINETICS
  • Modeling the course of plasma concentrations, optimization of dosage using software tools, factors affecting the course and value of the drug plasmatic concentration. Transport of drugs across biological barriers and membranes. Changes of the drug effect with repeated administration. Therapeutic drug monitoring (therapeutic monitoring of drug plasmatic concentrations).
  • DRUG APPLICATION METHODS/ROUTES OF DRUG ADMINISTRATION
  • /3/ WEDNESDAY
  • GENERAL RULES AND PRINCIPLES OF THE DRUG PRESCRIPTION
  • Medical prescription and its essentials. Prescription of drug preparations. Legislation of drug preparations and drug prescription. Work with various manuals, handbooks and databases (SÚKL database, Pharmindex, AISLP etc.).
  • PRESCRIPTION OF READY MADE PREPARATIONS
  • /4/ THURSDAY
  • DRUG DOSAGE FORMS - OVERVIEW (FLUID, SOFT AND MELTING DRUG DOSAGE FORMS)
  • Prescriptions of selected drug forms (fluid drug dosage forms - solutions for rubbing, compresses and lavages, solutions and drops for oral administration; soft and melting drug dosage forms – ointments, creams, pastes, gels and other preparations for application to the skin and mucous membranes). Prescription ready made preparations - practice. Routes of drug administration - overview.
  • PRESCRIPTION OF READY MADE PREPARATIONS - EXERCISE AND PRACTICING
  • /5/ FRIDAY
  • DRUG DOSAGE FORMS - OVERVIEW - continued (SOLID AND GASEOUS DRUG DOSAGE FORMS)
  • Prescriptions of selected drug forms (solid drug dosage forms – powders, capsules, tablets, suppositories; gaseous drug dosage forms - examples of inhalation preparations).
  • 2nd week
  • /6/ MONDAY
  • BANK HOLIDAY
  • /7/ TUESDAY
  • INTRODUCTION TO PHARMACODYNAMICS
  • Mechanisms of drug effects - non-specific and specific (direct and indirect)
  • PHARMACOLOGY OF PERIPHERAL NERVOUS SYSTEM - introduction
  • Terminology, neurotransmissions in peripheral nervous system, adrenergic and cholinergic receptors, agonists and antagonists. Functional importance and possibilities of pharmacological affection of sympathetic and parasympathetic system.
  • /8/ WEDNESDAY
  • NORADRENERGIC (SYMPATHETIC) DRUGS
  • Receptors of noradrenergic (sympathetic) system, pharmacology of drugs activating and blocking noradrenergic (sympathetic) system.
  • PRESCRIPTION TEST (PRESCRIPTION OF INDIVIDUALLY PREPARED AND READY MADE PREPARATIONS)
  • /9/ THURSDAY
  • CHOLINERGIC (PARASYMPATHETIC) DRUGS
  • Receptors of cholinergic (parasympathetic) system, pharmacology of drugs activating and blocking cholinergic (parasympathetic) system.
  • /10/ FRIDAY
  • H1 - ANTIHISTAMINES, DRUGS USED FOR THE TREATMENT OF BRONCHIAL OBSTRUCTION
  • Effects of histamine, the possibilities of histamine effects antagonizing. Histamine receptors. Classification and overview of H1 - antihistamines. Sympathomimetics and parasympatholytics used in diseases with bronchial obstruction.
  • MULTIPLE CHOICE FINAL (CREDIT) TEST OF PHARMACOLOGY (MCHQ - topics lessons from days 1 to 9)
  • CREDITS
Literature
    required literature
  • Ritter J et al. Rang and Dale's pharmacology. 9th Edition. Edinburgh: Elsevier [2020].
  • Landa Leoš, Jan Juřica, Kristýna Nosková, Ondřej Zendulka: Vybrané kapitoly z obecné farmakologie pro studenty všeobecného a zubního lékařství na LF MU. Multimediální podpora výuky klinických a zdravotnických oborů: Portál LF MU.
  • NOVÁKOVÁ, Jana, Barbora ONDRÁČKOVÁ and Alexandra ŠULCOVÁ. Základy receptury léčivých přípravků pro praktická cvičení z farmakologie - obor Zubní lékařství. Brno: Multimediální podpora výuky klinických a zdravotnických oborů: Portál Lékařské fakulty Masarykovy univerzity, 2010, 96 pp. ISSN 1801-6103. URL info
    recommended literature
  • RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info
  • http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
  • ŠVIHOVEC, Jan a kol. Farmakologie, Praha: Grada, 2018. ISBN 978-80-247-5558-8. www.grada.cz/farmakologie-(1)-8687
  • Markova farmakoterapie vnitřních nemocí. Edited by Josef Marek - Michal Vrablík. 5., zcela přepracované a d. Praha: Grada, 2019, xxiv, 868. ISBN 9788024750781. info
  • Demlová Regina, Říhová Barbora, Grycová Zuzana, Nerušilová Kateř. Životní cyklus léčiv. MASARYKOVA UNIVERZITA LÉKAŘSKÁ FAKULTA, 2014.
  • http://portal.med.muni.cz/clanek-621-zivotni-cyklus-leciv-klinicke-hodnoceni-a-registrace-lecivych-pripravku-farmakovigilance-a-stanovovani-cen-a-uhrad-leciv.html
  • Základy speciální receptury léčivých přípravků, Juřica a kol., 2014, http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
  • Soubor kazuistik z farmakologie, Zendulka a kol., 2016 http://elportal.cz/publikace/kazuistiky-farmakologie
  • Atlas léčivých rostlin, https://is.muni.cz/auth/do/med/el/lecive_rostliny/atlas.html
    not specified
  • Výzkum nových léčiv od zrodu k registraci, Starobová a kol., 2006, http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
  • Farmakovigilance a propagace léčiv, Vršková a kol., 2007, http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Practicals in Pharmacology, 2009, http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • Základy farmakoekonomiky, Říhová a kol, 2016, http://portal.med.muni.cz/clanek-649-zaklady-farmakoekonomiky.html
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info
  • MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 2., zcela přeprac. a doplň. Praha: Grada, 2014. ISBN 9788024713564. info
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
  • DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006, 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
Teaching methods
Practicals, the teaching process of include theoretical setting up as well as practical training of knowledge and skills stated in Syllabus. Included are also individual work with specific pharmacological softwares and homeworks on the selected topics, presented and discussed afterward in class.
Assessment methods
The participation in practicals is obligatory and registered. To get credits a student has to pass 2 written tests: 1) on drug prescription + translation of selected prescription expressions into Latin (assessed individually by the teacher), 2) the multiple-choice test on knowledge of topics taught. More than half correctly answered questions (usually from 15) are required.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2024, spring 2025.
  • Enrolment Statistics (spring 2023, recent)
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