aZLPF0622p Pathological Physiology II - lecture

Faculty of Medicine
spring 2023
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. MUDr. Anna Vašků, CSc. (lecturer)
prof. MUDr. Julie Dobrovolná, Ph.D. (lecturer)
MUDr. Michal Jurajda, Ph.D. (lecturer)
prof. MUDr. Kateřina Kaňková, Ph.D. (lecturer)
prof. RNDr. Michal Masařík, Ph.D. (lecturer)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (lecturer)
Bc. Lenka Hladíková (assistant)
prof. MUDr. Lydie Izakovičová Hollá, Ph.D. (assistant)
Mgr. Lucie Štrublová (assistant)
Guaranteed by
prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Anna Vašků, CSc.
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Timetable
Tue 16:00–17:40 B22/116 aula
Prerequisites (in Czech)
aZLPF0521c Pathophysiol. I - practice && aZLBC0422p Biochemistry II - lecture && aZLFY0422p Physiology II - lecture
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the subject is to train students in dynamic thinking about etiology and pathogenesis of diseases focused on special pathophysiology themes:
Pathophysiology of cardiovascular system.
Pathophysiology of digestive system, nutrition deficits.
Pathophysiology of endocrine system, metabolic diseases.
Pathophysiology of hemopoietic system, neoplasias.
Rheumatic diseases. Immunologically conditioned diseases.
Pathophysiology of respiratory tract.
Pathofphysiology of kidneys, disturbances in metabolism of water and ions.
Pathophysiology of nervous system.
Pathophysiology of muscles and sensory organs.
Learning outcomes
Student will be able:
- to explain the pharmacological options affecting the secretion of gastric juice in the context of experimentally induced gastric ulcer in experimental animal model (inhibition of proton pump, H2 receptor blockade);
- to explain the pharmacological options affecting the secretion of gastric juice in the context of experimentally induced gastric ulcer in experimental animal model (inhibition of proton pump, H2 receptor blockade);
- to demonstrate the principle of load test (oGTT) in an animal model of experimentally induced diabetes (alloxan);
- to identify clinically relevant parameters describe nutritional status (calorimetry, BMI, WHR index, the weight, the skin-fold thickness, bioimpedance, DEXA) ;
- todemnostrate the examination of the quality of the skin barrier, through the examination of resistance and conductivity of the skin or a chemical (Burckhardt´s) examination with regard to the composition of the skin barrier;
- to demonstrate onset of obstruction icterus induced by ligation of ductus choledochus. He understands etiopathogenesis of other types of icterus (hemolytic, hepatic) and diagnostics of them using heme metabolites in urine, blood and stool using mitochondrial/cytoplasmatic membranes liver enzymes;
- to describe etiopathogenesis of venous thrombosis using data from experimental animal model;
- to explain the importance and principles of DNA d iagnostics to detect I/D polymorphism using PCR methodology ACE
Syllabus
  • 1. Pathophysiology of GIT II – bowel diseases (incl. IBD) and etiopathogenesis of common malabsorption syndromes
  • 2. Pathophysiology of GIT III – etiopathogenesis of liver, pancreas and biliary tract disorders
  • 3. Pathophysiology of endocrine system I – homeostasis, principles of regulation and its disorders, chronobiology, central endocrine glands (hypothalamus, pituitary)
  • 4. Pathophysiology of endocrine system II – reproductive endocrinology disorders (ovaries, testes), abnormalities of fertility (PCOS), fetoplacental unit and pathophysiology of pregnancy (preeclampsia etc.)
  • 5. Pathophysiology of endocrine system III – adrenal cortex and medulla, thyroid gland
  • 6. Pathophysiology of endocrine system IV – parathyroid gland, metabolism and deficiency of D vitamins, calcium and phosphate metabolism disorders, pathological bone remodelling
  • 7. Pathophysiology of age-related processes, aging, longevity, death
  • 8. Pathophysiology of hematopoietic system I – haematological malignancies and precancerous states (myelodysplastic syndrome, leukaemias, lymphomas and multiple myeloma)
  • 9. Pathophysiology of hematopoietic system II – disorders of primary and secondary haemostasis (common hypo- and hypercoagulation states), thrombosis and embolization in typical locations
  • 10. Guest: Pathophysiology of hematopoietic system II – iron metabolism regulation and its disorders, etiopathogenesis of selected forms of anaemias (sideropenic, chron. disease), iron overload
  • 11.Pathophysiology of musculoskeletal system (bones, joints and muscles) incl. rheumatology (arthritis in systemic autoimmune diseases), muscular dystrophies, sarcopenia etc.
  • 12. Pathophysiology of nervous system I - motoric system (motoneurons, neuro-muscular junction, extrapyramidal system, cerebellum)
  • 13. Pathophysiology of nervous system II – etiopathogenic mechanisms od selected CNS disease (demyelinisation, neurodegeneration, neuroinflammation)
  • 14. Dean’s day
  • 15. Integrated pathophysiology of fluid, electrolyte and pH homeostasis
Literature
    required literature
  • NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 1. vyd. Praha: Karolinum, 2003, s. 381-760. ISBN 9788024606743. info
  • NEČAS, Emanuel. Patologická fyziologie orgánových systémů. 1. vyd. Praha: Karolinum, 2003, 379 s. ISBN 9788024606750. info
  • NEČAS, Emanuel a spol. Obecná patologická fyziologie. 1. vyd. Praha: Karolinum, 2000, 377 pp. ISBN 80-246-0051-X. info
Teaching methods
Lecture.
Assessment methods
Oral exam. The final exam is oral; student will answer 4 questions selected by lot from general, special pathophysiology, practicals and lectures. Individual evaluation from practicals (described by assistant) is taken into account.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught each semester.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2024, spring 2025.
  • Enrolment Statistics (spring 2023, recent)
  • Permalink: https://is.muni.cz/course/med/spring2023/aZLPF0622p