BVBC0221p Biochemistry - lecture

Faculty of Medicine
spring 2024
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
Mgr. Marie Tomandlová, Ph.D. (lecturer)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. David Galuška (assistant)
doc. PharmDr. Jiří Kos, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
prof. RNDr. Eva Táborská, CSc. (assistant)
MUDr. Michaela Králíková, Ph.D. (alternate examiner)
Guaranteed by
Mgr. Marie Tomandlová, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Mon 19. 2. to Mon 18. 3. Mon 8:50–10:40 B11/114, Mon 8. 4. to Mon 27. 5. Mon 8:50–10:40 B11/114; and Mon 25. 3. 8:50–10:40 B11/234
Prerequisites (in Czech)
BVLC011s Med.Chem.-seminar && BVLC011c Medical Chemistry -p
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to obtain knowledge on essential metabolic processes on the cell level.
Learning outcomes
In the end of the course will students:
- understand the properties and function of enzymes
- describes basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism, and their relationships
- understand the principles of energy production, utilization and deposition at the cellular level
- explain the function of cell membranes and the transport processes on the membrane
- describe protein synthesis, understand the relationship between protein structure and function
- explain the function of hemoglobin in oxygen transport and maintaining acid-base balance
Syllabus
  • Enzymes, properties, classification, quantification, kinetics. Factors influencing the speed of enzyme reactions.
  • Enzyme cofactors. Introduction to Metabolism. Macroergic compounds.
  • Three phases of nutrient catabolism. Citrate cycle. Respiratory chain. Oxidative phosphorylation. Reactive oxygen species, antioxidants.
  • Digestion of carbohydrates. Introduction to Carbohydrate Metabolism. Glycolysis. Gluconeogenesis. Synthesis and breakdown of glycogen.
  • Pentose cycle. Metabolism of fructose and galactose. Mutual transformations of carbohydrates in the cell, formation of carbohydrate derivatives.
  • Protein digestion and intracellular degradation.
  • General mechanisms of biodegradation of amino acids. Ammonia detoxification and transport. Metabolism of individual amino acids.
  • Digestion of lipids. Fatty acid metabolism. Ketogenesis and ketolysis. Metabolism of triacylglycerols. Metabolism of phospholipids and glycolipids. Eicosanoids. Metabolism of cholesterol and bile acids.
  • Synthesis and degradation of heme. Hemoglobin.
  • Metabolism of nucleotides and their bases. DNA replication.
  • DNA transcription. Regulation of gene expression.
  • Proteosynthesis, post-translational modifications.
Literature
    required literature
  • LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny. 3. vydání. Praha: Univerzita Karlova, nakladatelství Karolinum, 2020, 269 stran. ISBN 9788024647487. info
  • Studijní podklady a materiály k předmětu dostupné v IS MUNI.
    recommended literature
  • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017, viii, 567. ISBN 9781496363541. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Grada. Praha, 2012, 498 pp. ISBN 978-80-247-2977-0. info
  • MATOUŠ, Bohuslav. Základy lékařské chemie a biochemie. 1. vyd. Praha: Galén, 2010, xv, 540. ISBN 9788072627028. info
Teaching methods
Teaching form is lecture.
Assessment methods
Oral examination.
Student draws a total of three questions. Student answers questions without preparation.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
Information on completion of the course: přistoupení ke zkoušce je podmíněno úspěšným ukončením předmětů BVLC011p a BVBC0221s.
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses

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Teacher's information
https://is.muni.cz/auth/el/med/jaro2024/BVBC0221p/
The course is also listed under the following terms Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2025.
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