aZLBI0222c Biology II - practice

Faculty of Medicine
spring 2024
Extent and Intensity
0/2/0. 1 credit(s). Type of Completion: z (credit).
Teacher(s)
Mgr. Kateřina Cetkovská, Ph.D. (lecturer)
Ing. Lívia Eiselleová, Ph.D. (lecturer)
Mgr. Kateřina Francová, Ph.D. (lecturer)
prof. RNDr. Ondřej Slabý, Ph.D. (lecturer)
prof. MUDr. Iva Slaninová, Ph.D. (lecturer)
Mgr. Kateřina Straková, Ph.D. (lecturer)
Jana Růžičková (assistant)
Guaranteed by
prof. MUDr. Iva Slaninová, Ph.D.
Department of Biology – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Kateřina Francová, Ph.D.
Supplier department: Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Mon 19. 2. 9:00–9:30 B07/214, 9:30–10:30 B07/217, 9:30–10:30 B07/214, 10:30–10:40 B07/214, Mon 26. 2. 9:00–9:30 B07/214, 9:30–10:30 B07/217, 9:30–10:30 B07/214, 10:30–10:40 B07/214, Mon 4. 3. 9:00–9:30 B07/214, 9:30–10:30 B07/217, 9:30–10:30 B07/214, 10:30–10:40 B07/214, Mon 11. 3. 9:00–9:30 B07/214, 9:30–10:30 B07/217, 9:30–10:30 B07/214, 10:30–10:40 B07/214, Mon 18. 3. 9:00–9:30 B07/214, 9:30–10:30 B07/214, 9:30–10:30 B07/217, 10:30–10:40 B07/214, Mon 25. 3. 9:00–9:30 B07/214, 9:30–10:30 B07/217, 9:30–10:30 B07/214, 10:30–10:40 B07/214, Mon 8. 4. 9:00–9:30 B07/214, 9:30–10:30 B07/217, 9:30–10:30 B07/214, 10:30–10:40 B07/214, Mon 15. 4. 9:00–9:30 B07/214, 9:30–10:30 B07/217, 9:30–10:30 B07/214, 10:30–10:40 B07/214, Mon 22. 4. 9:00–9:30 B07/214, 9:30–10:30 B07/217, 9:30–10:30 B07/214, 10:30–10:40 B07/214, Mon 29. 4. 9:00–9:30 B07/214, 9:30–10:30 B07/214, 9:30–10:30 B07/217, 10:30–10:40 B07/214, Mon 6. 5. 9:00–9:30 B07/214, 9:30–10:30 B07/217, 9:30–10:30 B07/214, 10:30–10:40 B07/214, Mon 13. 5. 9:00–9:30 B07/214, 9:30–10:30 B07/217, 9:30–10:30 B07/214, 10:30–10:40 B07/214, Mon 20. 5. 9:00–9:30 B07/214, 9:30–10:30 B07/217, 9:30–10:30 B07/214, 10:30–10:40 B07/214
Prerequisites (in Czech)
aZLBI0121c Biology I - pract.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main objectives of the course are:
- learning the methods of risk evaluation for hereditary diseases of various molecular background in patients based on family anamneses
- understanding the basic principles of gene engineering
- understanding and practising selected molecular methods used for examination of some cancers or hereditary and infectious diseases with regard to the selection of appropriate therapy
Learning outcomes
After completing the course, the student will be able to:
- evaluate the risk of hereditary diseases of various molecular background in patients based on assigned family anamneses of the diseases
- describes the basic principles of genetic prognosis and genetic counselling
- suggest and perform basic molecular-genetic diagnostic examinations of some hereditary, tumour and infectious diseases (PCR, restriction digest, gel electrophoresis), and to interpret the obtained results
- explain selected basic techniques of gene engineering and their application in medicine, and, with knowledge of the used method, to select the clones of cells with an inserted gene
Syllabus
  • Week 1: Genetic disorders - autosomal inheritance
  • Week 2: Genetic disorders - gonosomal inheritance
  • Week 3: Extensions to basic genetics
  • Week 4: Genetic prognosis and genetic counselling
  • Week 5: Human population genetics
  • Week 6: Control test 3 (knowledge from week 1 to week 5 of the spring semester - lectures, practices)
  • Week 7: Molecular diagnostics of human pathogenic bacteria (1st HALF OF THE GROUP)
  • Week 8: Molecular diagnostics of human pathogenic bacteria (2nd HALF OF THE GROUP)
  • Week 9: Gene engineering – production of human proteins in bacterial cells (PUBLIC HOLIDAY - NO PRACTICE)
  • Week 10: Gene engineering – production of human proteins in bacterial cells (ALL DENTISTRY STUDENTS)
  • Week 11: Molecular diagnostics of cancer (ALL DENTISTRY STUDENTS)
  • Week 12: Molecular diagnostics of cancer (PUBLIC HOLIDAY - NO PRACTICE)
  • Week 13: Control test 4 (knowledge from week 7 to week 12 of the spring semester - lectures, practices) (PUBLIC HOLIDAY - will be substituted)
  • Week 14: no practices, Re-sit test
  • Week 15: no practices, credit awarding
Literature
    required literature
  • Protocols for practices are provided in electronic form in the Information System of the Masaryk University in the Study Materials of the course aZLBI0222c
Teaching methods
laboratory practice, class discussion
Assessment methods
Practical classes are mandatory.
Requirements for course completion: full attendance in the practices (1 absence, excused or unexcused, is allowed); all protocols completed (also for missed lessons) and checked and signed by appropriate teachers; successfully passed 2 written control tests during the semester (knowledge from lectures and practices, 20 questions in each test, 1 answer correct to be chosen from 4 possibilities, student needs to reach at least 24 points out of 40 from both of the tests). In case you do not pass control tests (you have less than 24 points), you write a re-sit of control test (knowledge from lectures and practices of entire semester, 20 questions, 1 answer correct to be chosen from 4 possibilities, student needs to reach at least 12 points). If you do not pass the re-sit of control test, you have to write the final test (Credit test) based on knowledge of the entire semester lectures and practices. Credit test comprises 20 questions: 10 test questions (multiple answers can be correct, negative marking is obtained for incorrect answers) + 10 given terms for a written explanation. At least 10 points out of 20 are needed to pass.
In case of a student’s late arrival to the practice or poor activity at the practice, the student is required to write an essay in the length of 2 pages on a given topic. Same for the case of two absences in practices (excused or unexcused). Find the instructions for essay writing in the Instructions for the course in Interactive syllabus in the IS. Bring the essay printed to the teacher who specified the topic (after making an appointment in consulting hours), and be ready to answer the teacher's questions regarding the topic.
In case of 3 absences (excused or unexcused), (or more than 3 absences all excused by the Office for Studies within 5 days from the beginning of the absence and introduced to the Information System), it is addressed individually and course-unit credit is awarded only after the proof of the student's knowledge of the entire semester topics (Credit test, see above).
In the case of 4 or more unexcused absences, the course-unit credit is not awarded.
Language of instruction
English
Follow-Up Courses
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 30.
Listed among pre-requisites of other courses
Teacher's information
https://is.muni.cz/auth/el/med/jaro2023/aZLBI0222c/index.qwarp
Interactive syllabus of the course:

https://is.muni.cz/auth/el/med/jaro2024/aZLBI0222c/index.qwarp

What to bring to each practice: printed protocol for the respective practice, your own writing materials. Download the protocol for each practice from the Study materials or Interactive syllabus in the IS, and study it in advance. Lab shoes required, lab coats and disposable gloves are not required, but for the tasks with staining lab coats are recommended.

Substitution of practices: In exceptional cases (illness, appointment at the doctor’s or foreign policy, 1 or 2 times per semester as maximum) students can arrange a substitution with another group (Dentistry students are allowed to substitute in groups of General medicine students). To arrange a substitution, write an e-mail to the contact person of your course at least 24 hours before your planned substitution and specify the group (date and time) you would like to attend instead (see Interactive syllabus of your course - Instructions for the course - Timetable..). Substitution is only possible on the same teaching week. When the capacity of the group you intended to substitute with is fully used, the substitution does not need to be approved. Repeated substitution with other groups is not allowed.

Complete Biology instructions to be found at the following link:

https://is.muni.cz/auth/el/med/jaro2024/aZLBI0222c/op/Biology_practices_instructions.pdf?predmet=1517831;qurl=%2Fel%2Fmed%2Fjaro2024%2FaZLBI0222c%2Findex.qwarp

The course is also listed under the following terms Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2025.
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