ZLBC0422p Biochemistry II - lecture

Faculty of Medicine
spring 2025
Extent and Intensity
1/0/0. 3 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (lecturer)
RNDr. Hana Paulová, CSc. (lecturer)
Mgr. Jiří Slanina, Ph.D. (lecturer)
prof. RNDr. Eva Táborská, CSc. (lecturer)
doc. RNDr. Josef Tomandl, Ph.D. (lecturer)
Mgr. Jana Gregorová, Ph.D. (assistant)
doc. PharmDr. Jiří Kos, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
doc. Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
PharmDr. Kristýna Šebrlová, Ph.D. (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Prerequisites (in Czech)
ZLFY0321s Physiology I - sem. && ZLBI0222p Biology II-lect. && ( ZLBC0321s Biochemistry I - seminar || ZLBC0221s Biochemistry I - seminar )
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The course extends the knowledge of biochemistry acquired in the course Biochemistry I and deals with integration of biochemical processes in human body. The aim is to understand biochemical processes characteristic for individual tissues and organs and principles of their regulation. It focuses on the relationship between health and disease from a biochemical point of view. It points to the links between biochemical principles and other medical subjects such as physiology, immunology, pharmacology, toxicology and others. Special attention is focused on biochemical processes in oral cavity and biochemical aspects of dental tissues.
Learning outcomes
The student is able to explain the interrelationship between the metabolism of nutrients under different states of the organism. Describes the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases. Understands and discusses principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations It discusses the composition of body fluids and their disorders in connection with the principles of homeostasis. It explains the principles of metabolism regulation at all levels.
Syllabus
  • Blood plasma lipids. Lipoprotein metabolism.
  • Integration of intermediary metabolism at tissue and organ level under various conditions.
  • Metabolic functions of liver. Catabolism of haemoglobin. Metabolism of iron.
  • Biotransformation of xenobiotics, cytochromes P450. Metabolism of ethanol.
  • Homeostasis of water and Na+, K+ ions, plasma osmolality, volemia.
  • Acid-base balance. Transport of O2 and CO2. Buffer bases, parameters of acid-base status.
  • Biochemical functions of kidney. Glomerular filtration. Tubular resorption and secretion.
  • Control of metabolism. Common mechanisms of action of signal molecules.
  • Nervous tissue. Neurosecretion. Neurotransmitters, processes at synapses.
  • Metabolism of calcium, magnesium, phosphates, fluorine, and iodine.
  • Extracellular matrix. Hard tissues, mineralization.
  • Saliva and oral homeostasis. Tooth plaque. Influence of nutrition on oral health.
  • Vascular endothelium. Biochemistry of blood elements. Basics of immunochemistry.
  • Blood plasma proteins. Coagulation cascade, fibrinolysis.
Literature
    required literature
  • LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny. 3. vydání. Praha: Univerzita Karlova, nakladatelství Karolinum, 2020, 269 stran. ISBN 9788024647487. info
  • Studijní podklady a materiály k předmětu dostupné v IS MU.
    recommended literature
  • FERRIER, Denise R. Biochemistry. 6th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2014, 552 s. ISBN 9781451175622. info
  • Doporučovaná literatura z lékařské fyziologie v předmětu ZLFY0422p.
  • MURRAY, Robert K., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY, Victor W. RODWELL and P. Anthony WEIL. Harperova ilustrovaná biochemie. Translated by Bohuslav Matouš. Páté české vydání, prv. Praha: Galén, 2012, xii, 730. ISBN 9788072629077. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. Grada. Praha, 2012, 498 pp. ISBN 978-80-247-2977-0. info
Teaching methods
Lectures
Assessment methods
Oral exam. Student draws two questions from Biochemistry I and two questions from Biochemistry II. The student answers the questions without preparation.
Language of instruction
Czech
Further comments (probably available only in Czech)
Information on completion of the course: přistoupení ke zkoušce je podmíněno úspěšným ukončením předmětů ZLBC0422s a ZLBC0422c.
The course is taught annually.
The course is taught: every week.
Information on the extent and intensity of the course: 15.
Listed among pre-requisites of other courses

Zobrazit další předměty

Teacher's information
The basic concepts and topics included in the Biochemistry II exam are available in the Course-Related Instructions in IS MU.
The course is also listed under the following terms spring 2020, spring 2021, spring 2022, spring 2023, spring 2024.
  • Enrolment Statistics (spring 2025, recent)
  • Permalink: https://is.muni.cz/course/med/spring2025/ZLBC0422p