FaF:F1AL1_15 Analysis of Drugs - Course Information

F1AL1_15 Analysis of Drugs

Extent and Intensity

2/3/0. 8 credit(s). Type of Completion: zk (examination).

Teacher(s)

doc. PharmDr. Ing. Radka Opatřilová, Ph.D., MBA (lecturer)
Mgr. Adéla Lamaczová (seminar tutor)
Ing. Klára Odehnalová, Ph.D. (seminar tutor)
doc. PharmDr. Ing. Radka Opatřilová, Ph.D., MBA (seminar tutor)
PharmDr. Tereza Padrtová, Ph.D. (seminar tutor)
Mgr. Hana Pížová, Ph.D. (seminar tutor)

Guaranteed by

doc. PharmDr. Ing. Radka Opatřilová, Ph.D., MBA
Department of Chemical Drugs – Departments – Faculty of Pharmacy
Supplier department: Department of Chemical Drugs – Departments – Faculty of Pharmacy

Timetable

Fri 10:30–12:00 44-056

• Timetable of Seminar Groups:

F1AL1_15/01: each even Monday 7:30–12:00 44-339, K. Odehnalová, R. Opatřilová, H. Pížová
F1AL1_15/02: each odd Monday 7:30–12:00 44-339, K. Odehnalová, R. Opatřilová, H. Pížová
F1AL1_15/03: each even Monday 14:00–18:30 44-339, R. Opatřilová, T. Padrtová
F1AL1_15/04: each odd Monday 14:00–18:30 44-339, K. Odehnalová, R. Opatřilová, T. Padrtová
F1AL1_15/05: each even Tuesday 13:00–17:30 44-339, A. Lamaczová, R. Opatřilová
F1AL1_15/06: each odd Tuesday 13:00–17:30 44-339, R. Opatřilová, T. Padrtová

Prerequisites (in Czech)

FAKULTA(FaF) || OBOR(MUSFaF)

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

The capacity limit for the course is 160 student(s).
Current registration and enrolment status: enrolled: 1/160, only registered: 0/160

fields of study / plans the course is directly associated with

• Pharmacy (programme FaF, M-FARM)
• Multidisciplinary studies at Faculty of Pharmacy (programme CST, KOS)

Course objectives

Drug Analysis course aims to teach students to work methods and procedures used in the control practices for providing efficient, reliable and safe medicines.
The subject is the interpretation of the principles of analysis - chemical and physico-chemical methods used in assessing individual indicators of quality (identity, purity, content, stability) of single chemically active substances, excipients and medicinal products.

Learning outcomes

Learning outcomes of the course are theoretical knowledge and practical experience of students of methods used for comprehensive evaluation of drugs and medicinal products in accordance with applicable regulations in the Czech Republic and the EU. The content of the course is based on the requirements of the European Pharmacopoeia as a supranational legal norm. The graduate of the course Drug Analysis is to master the basic procedures and methods of pharmacopoeial evaluation of drugs. Evidence of drugs based on physical constants, using instrumental-analytical methods and chemical reactions. To control group and selective reactions of structural types of drugs within pharmacotherapeutic groups. He has mastered the technique of limit tests for the purity of drugs, volumetric and gravimetric determination of drugs and pharmaceutical excipients. He should be able to perform analytical evaluation of drugs and medicinal products using chromatographic, spectral and electroanalytical methods. He should be able to perform experimental studies of medicinal products, evaluation of relevant physical and chemical parameters, including detection and quantification of degradation products, according to the given procedure.

Syllabus

• LECTURES
  Basic: Pharmacopeia
  Purity and stability of drugs
  Pharmacopoeial detection of impurities with the use of chemical reactions by means of physicochemical methods
  Drug Identification
  * Detection of drugs by means of chemical reactions
  * Group and selective reactions of pharmacotherapeutic groups
  * Detection of drugs on the basis of physical constants (melting point, distillation range, density, refractive index, optical rotation)
  * Use of physicochemical methods for the detection of drugs (spectral, separational, electrochemical methods)
  Drug Assay
  * Volumetric methods used in drugs anaysis
  * Acid-base titrations of drugs (acidimetry, alkalimetry in aqueous and nonaqueous media)
  * Oxidoreduction titrations of drugs (iodometry, bromatometry, manganometry, cerimetry)
  * Complexometric titrations of drugs (chelatometry, mercurimetry)
  * Determination of drugs by means of precipitation titrations
  Spectrophotometric determination of drugs
  Polarimetric determination of drugs
  Determination of drugs with the use of electroanalytical methods
  Determination of drugs by chromatographic and electrophoretic methods
  Stability of drugs, processes of decomposition, factors influencing stability
  
  PRACTICAL TRAINING
  - Control-analytical evaluation of drugs according to the Pharmacopoeia
  - Test for purity of drugs (chemical detection of impurities)
  - Test for purity of drugs (detection of impurities, or degradation products by chromatographic and spectral methods)
  - Identification of drugs by means of chemical reactions, physical constants, physicochemical methods
  - Determination of drug content (pharmacopoeial methods of quantitative evaluation of drugs)
  - Control-analytical evaluation of pharmaceutical preparations
  - Control of extemporaneously prepared pharmaceutical preparations according to the pharamacopoeia and control-analytical procedures used in drug control laboratories
  - Control of mass-produced pharmaceutical preparations according to factory standards
  - Instrumental methods (use of UV spectrometry in drug control, control, analysis of drugs on the basis of specific optical rotation, analysis of drugs by means of chromatography)
  

Literature

recommended literature
• Ministerstvo zdravotnictví. Český lékopis 2017. 2017. info

Teaching methods

lectures practical laboratory practice

Assessment methods

written tests in laboratory, oral examination

Language of instruction

Czech

Further Comments

Study Materials
The course can also be completed outside the examination period.

• Enrolment Statistics (Autumn 2020, recent)
  
• Permalink: https://is.muni.cz/course/pharm/autumn2020/F1AL1_15