F1AL1_15 Analysis of Drugs

Faculty of Pharmacy
Autumn 2023
Extent and Intensity
2/3/0. 8 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. PharmDr. Ing. Radka Opatřilová, Ph.D., MBA (lecturer)
doc. PharmDr. Ing. Radka Opatřilová, Ph.D., MBA (seminar tutor)
Mgr. Hana Pížová, Ph.D. (seminar tutor)
PharmDr. Bc. Lenka Coufalová, Ph.D. (seminar tutor)
Mgr. Karolína Šeligová (seminar tutor)
Guaranteed by
doc. PharmDr. Ing. Radka Opatřilová, Ph.D., MBA
Department of Chemical Drugs – Departments – Faculty of Pharmacy
Supplier department: Department of Chemical Drugs – Departments – Faculty of Pharmacy
Timetable
Fri 10:45–12:25 44-056
  • Timetable of Seminar Groups:
F1AL1_15/01: each odd Monday 7:30–12:30 44-339, except Mon 18. 12., except Mon 1. 1., R. Opatřilová
F1AL1_15/02: each even Monday 7:30–12:30 44-339, L. Coufalová, R. Opatřilová
F1AL1_15/03: each odd Monday 13:00–18:00 44-339, except Mon 18. 12., except Mon 1. 1., L. Coufalová, R. Opatřilová, K. Šeligová
F1AL1_15/04: each even Monday 13:00–18:00 44-339, L. Coufalová, R. Opatřilová, H. Pížová
F1AL1_15/05: each even Tuesday 13:00–18:00 44-339, except Tue 19. 12., except Tue 2. 1., R. Opatřilová, K. Šeligová
Prerequisites (in Czech)
FAKULTA(FaF) || OBOR(MUSFaF)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.

The capacity limit for the course is 160 student(s).
Current registration and enrolment status: enrolled: 98/160, only registered: 0/160
fields of study / plans the course is directly associated with
Course objectives
Drug Analysis course aims to teach students to work methods and procedures used in the control practices for providing efficient, reliable and safe medicines.
The subject is the interpretation of the principles of analysis - chemical and physico-chemical methods used in assessing individual indicators of quality (identity, purity, content, stability) of single chemically active substances, excipients and medicinal products.
Learning outcomes
Learning outcomes of the course are theoretical knowledge and practical experience of students of methods used for comprehensive evaluation of drugs and medicinal products in accordance with applicable regulations in the Czech Republic and the EU. The content of the course is based on the requirements of the European Pharmacopoeia as a supranational legal norm. The graduate of the course Drug Analysis is to master the basic procedures and methods of pharmacopoeial evaluation of drugs. Evidence of drugs based on physical constants, using instrumental-analytical methods and chemical reactions. To control group and selective reactions of structural types of drugs within pharmacotherapeutic groups. He has mastered the technique of limit tests for the purity of drugs, volumetric and gravimetric determination of drugs and pharmaceutical excipients. He should be able to perform analytical evaluation of drugs and medicinal products using chromatographic, spectral and electroanalytical methods. He should be able to perform experimental studies of medicinal products, evaluation of relevant physical and chemical parameters, including detection and quantification of degradation products, according to the given procedure.
Syllabus
  • LECTURES
    Basic: Pharmacopeia
    Purity and stability of drugs
    Pharmacopoeial detection of impurities with the use of chemical reactions by means of physicochemical methods
    Drug Identification
    * Detection of drugs by means of chemical reactions
    * Group and selective reactions of pharmacotherapeutic groups
    * Detection of drugs on the basis of physical constants (melting point, distillation range, density, refractive index, optical rotation)
    * Use of physicochemical methods for the detection of drugs (spectral, separational, electrochemical methods)
    Drug Assay
    * Volumetric methods used in drugs anaysis
    * Acid-base titrations of drugs (acidimetry, alkalimetry in aqueous and nonaqueous media)
    * Oxidoreduction titrations of drugs (iodometry, bromatometry, manganometry, cerimetry)
    * Complexometric titrations of drugs (chelatometry, mercurimetry)
    * Determination of drugs by means of precipitation titrations
    Spectrophotometric determination of drugs
    Polarimetric determination of drugs
    Determination of drugs with the use of electroanalytical methods
    Determination of drugs by chromatographic and electrophoretic methods
    Stability of drugs, processes of decomposition, factors influencing stability

    PRACTICAL TRAINING
    - Control-analytical evaluation of drugs according to the Pharmacopoeia
    - Test for purity of drugs (chemical detection of impurities)
    - Test for purity of drugs (detection of impurities, or degradation products by chromatographic and spectral methods)
    - Identification of drugs by means of chemical reactions, physical constants, physicochemical methods
    - Determination of drug content (pharmacopoeial methods of quantitative evaluation of drugs)
    - Control-analytical evaluation of pharmaceutical preparations
    - Control of extemporaneously prepared pharmaceutical preparations according to the pharamacopoeia and control-analytical procedures used in drug control laboratories
    - Control of mass-produced pharmaceutical preparations according to factory standards
    - Instrumental methods (use of UV spectrometry in drug control, control, analysis of drugs on the basis of specific optical rotation, analysis of drugs by means of chromatography)
Literature
    recommended literature
  • Ministerstvo zdravotnictví. Český lékopis 2017. 2017. info
Teaching methods
lectures practical laboratory practice
Assessment methods
written tests in laboratory, oral examination
Language of instruction
Czech
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is also listed under the following terms Autumn 2020, Autumn 2021, Autumn 2022, Autumn 2024.
  • Enrolment Statistics (Autumn 2023, recent)
  • Permalink: https://is.muni.cz/course/pharm/autumn2023/F1AL1_15