FAFO1_13 Dosage Forms and Biopharmacy I

Faculty of Pharmacy
Autumn 2023
Extent and Intensity
3/6/0. 5 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. PharmDr. Aleš Franc, Ph.D. (lecturer)
doc. PharmDr. Jan Gajdziok, Ph.D. (lecturer)
doc. PharmDr. Kateřina Kubová, Ph.D. (lecturer)
PharmDr. Jakub Vysloužil, Ph.D. (lecturer)
doc. PharmDr. Aleš Franc, Ph.D. (seminar tutor)
doc. PharmDr. Jan Gajdziok, Ph.D. (seminar tutor)
doc. PharmDr. Kateřina Kubová, Ph.D. (seminar tutor)
PharmDr. Jakub Vysloužil, Ph.D. (seminar tutor)
PharmDr. Kateřina Brückner, Ph.D. (seminar tutor)
PharmDr. Miroslava Pavelková, Ph.D. (seminar tutor)
PharmDr. Jiří Zeman, Ph.D. (seminar tutor)
Guaranteed by
doc. PharmDr. Kateřina Kubová, Ph.D.
Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Timetable
Thu 9:55–12:25 18-122
  • Timetable of Seminar Groups:
FAFO1_13/01: Thu 13:00–18:00 18-107, K. Brückner, A. Franc, J. Gajdziok, K. Kubová, M. Pavelková, J. Vysloužil, J. Zeman
FAFO1_13/02: Thu 13:00–18:00 18-138, K. Brückner, A. Franc, J. Gajdziok, K. Kubová, M. Pavelková, J. Vysloužil, J. Zeman
Prerequisites (in Czech)
FAKULTA(FaF) || OBOR(MUSFaF)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
One of the main obligatory pharmaceutical disciplines dealing with preparation, manufacturing and quality control of medicaments including technological procedures, equiment, excipients and appropriate analytical devices. It covers the influence of the application form on drug bioavailability.
Learning outcomes
Upon successful completion of the course, students will be able to:
- theoretically know the classification, requirements, excipients, technological procedure of preparation and production of liquid dosage forms and their evaluation (solutions, emulsions, suspensions)
- theoretically know the classification, requirements, excipients, and technological procedure for the preparation and manufacture of ophthalmic, nasal, and ear preparations and their evaluation
- theoretically know the classification, requirements, excipients, and technological procedure for the preparation and manufacture of parenteral preparations and their evaluation
- theoretically know the classification, requirements, excipients, and technological procedure for the preparation and manufacture of semi-solid dosage forms and their evaluation (ointments, pastes, creams, gels)
- to determine the basic aspects of dosage forms in relation to the bioavailability of the drug
- to perform essential calculations (concentrations, doses, mixing equations, ratios, etc.)
- to check the doses of a drug in a medicinal product according to the prescription of the product according to Pharmacopoeia
- to prepare both pharmacopoeial and non-pharmacopoeial solutions, syrups, aromatic waters, suspensions, emulsions, eye drops, nasal drops, and ear drops skillfully
- to detect fundamental incompatibilities in the composition of individually formulated medicinal products
- to determine the shelf life of individually formulated medicinal products
- to select suitable packaging options for individually formulated medicinal products
- to estimate the optimal storage conditions required for individually formulated medicinal products
Syllabus
  • SYLLABUS OF LECTURES
    1.Pharmaceutical solutions.
    2. ---------- public holiday.
    3. Water for pharmaceutical purposes, sterilization methods.
    4. Eye preparations.
    5. Nasal and ear preparations.
    6. Parenteral dosage forms.
    7. Pharmaceutical emulsions.
    8 Pharmaceutical suspensions.
    9. Plants extracts and extraction methods.
    10. Semisolid dosage forms – ointments.
    11. Semisolid dosage forms - creams, gels, pastes.
    12. Powders and their characteristics.
    13. Capsules, their production and evaluation.

    SYLLABUS OF LABORATORY PRACTICE
    1. Pharmaceutical calculations
    2. ----- Public holiday
    3. Introduction to the practical training. Medicinal solutions: preparation at room and higher temperature, evaluation.
    4. Medicinal solutions: preparation by solubilization and chemical reaction, evaluation.Test - Pharmaceutical calculations.
    5. Syrups. Preparation and evaluation.
    6. Gels, mucillages. Preparation and evaluation
    7. Eye drops. Preparation and evaluation.
    8. Nasal and ear drops. Preparation and evaluation.
    9. Emulsions. Preparation and evaluation. Test - calculations for eye, nasal preparations.
    10. Suspensions. Preparation and evaluation.Test - emulsifiers.
    11. Preparation of liquid dosage forms according to prescriptions.
    12. Alternative training.
    13. Credit test, Laboratory skills testing
Literature
    required literature
  • The texts are available during the lectures. info
    recommended literature
  • Rowe, Sheskey, Owen. Handbook of Pharmaceutical Excipients. Great Britain, 2006. ISBN 1-58212-058-7. info
    not specified
  • European Pharmacopoeia, 9th Edition. 2017. info
Teaching methods
Lectures
Lab training
Homework
Assessment methods
Intermediate tests in laboratory exercises (3 tests, two retakes is possible)
Systematic observation of the student during laboratory classes, preparation of reports following the teacher's instructions
Credit test (credit test has two parts, part 1 - pharmaceutical calculations (limit for passing 75%), part 2 - test - closed and open questions from knowledge from lectures and laboratory classes (limit for passing - 60%).
Practical testing is conducted to evaluate students' skills as part of the credit assessment(preparation of the medicinal product - detection of incompatibilities, control of dosage, selection of the correct procedure, selection of appropriate packaging, correct labelling of the product - shelf life, storage conditions).
Language of instruction
English
Follow-Up Courses
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
Listed among pre-requisites of other courses
Teacher's information
Lectures are recommended due to lack of suitable literature.
Laboratory classes are obligatory (100 %).
Credit for courses will only be awarded where a student will:
- participate in 100% of lab part of the course (maximum in two cases, individual laboratory classes can be done later - alternative class according to syllabus)
- complete successfully three tests during semester
- complete successfully credit test in the end of the course
- complete successfully testing of laboratory skill in the end of the course.
The course is also listed under the following terms Autumn 2020, Autumn 2021, Autumn 2022, Autumn 2024.
  • Enrolment Statistics (Autumn 2023, recent)
  • Permalink: https://is.muni.cz/course/pharm/autumn2023/FAFO1_13