FAFO2_13 Dosage Forms and Biopharmacy II

Faculty of Pharmacy
Spring 2025
Extent and Intensity
3/6/0. 11 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
doc. PharmDr. Aleš Franc, Ph.D. (lecturer)
doc. PharmDr. Jan Gajdziok, Ph.D. (lecturer)
doc. PharmDr. Kateřina Kubová, Ph.D. (lecturer)
PharmDr. Jakub Vysloužil, Ph.D. (lecturer)
doc. PharmDr. Aleš Franc, Ph.D. (seminar tutor)
doc. PharmDr. Jan Gajdziok, Ph.D. (seminar tutor)
doc. PharmDr. Kateřina Kubová, Ph.D. (seminar tutor)
PharmDr. Jakub Vysloužil, Ph.D. (seminar tutor)
PharmDr. Kateřina Brückner, Ph.D. (seminar tutor)
PharmDr. Miroslava Pavelková, Ph.D. (seminar tutor)
PharmDr. Jiří Zeman, Ph.D. (seminar tutor)
Guaranteed by
doc. PharmDr. Kateřina Kubová, Ph.D.
Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Prerequisites
FAFO1_13 Dosage Forms and Biopharmacy
Dosage Forms and Biopharmacy I
Students can study this course only after completing the course Dosage Forms and Biopharmacy I
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.

The capacity limit for the course is 20 student(s).
Current registration and enrolment status: enrolled: 0/20, only registered: 0/20
fields of study / plans the course is directly associated with
Course objectives
One of the main obligatory pharmaceutical disciplines dealing with the preparation, manufacturing, and quality control of medicaments including technological procedures, equipment, excipients, and appropriate analytical devices. It covers the influence of the application form on drug bioavailability.
Learning outcomes
After completing the course, the student will:
- describe the theoretical aspects of semisolid dosage forms formulation and quality testing;
- describe the classification, requirements, excipients, and technological process of preparation and production of solid dosage forms, including their evaluation;
- theoretically describe the classification, requirements, excipients, technological process of preparation and production of dosage forms with controlled drug release, including their evaluation;
- know the basic aspects of semisolid and solid dosage forms about the drug bioavailability;
- describe the main conditions of GMP
- recognize selected incompatibilities in liquid and semisolid dosage forms and adjust the composition of pharmaceutical products;
- prepare semisolid (ointments, cremes, pastes, gels) and solid dosage forms (powders, granules, capsules, suppositories, vaginal globules) in pharmacy conditions
Syllabus
  • Topic of lecture
    Dosage forms for rectal application
    Dosage forms for vaginal application
    Granules, granulation methods. Evaluation of powders and granules
    Tablets, their production, and evaluation
    Pharmaceutical packaging
    Pharmaceutical incompatibilities in dosage forms
    Coated products, their production and evaluation
    Development of new drugs from galenical perspective
    Multiple-unit drug delivery systems
    Pharmaceutical aerodispersions
    Transdermal preparations
    Validation in pharmaceutical technology
    Controlled drug release
    Good manufacturing practice in pharmacy

    Practical labs
    Semisolid dosage forms - Ointments
    Semisolid dosage forms - Creams
    Semisolid dosage forms - Pastes, Gels
    Test - semisolid preparation. Rectal and vaginal dosage forms - theoretical aspect of preparation
    Rectal and vaginal dosage forms
    Technological processes in preparation of difficult prescriptions I. Test - suppositories, vaginal globules.
    Technological processes in preparation of difficult prescriptions II.
    Divided and non-divided pharmaceutical powders. Preparation and evaluation
    Alternative training
    Wet and melt granulations
    Tablets preparation by direct compression
    Evaluation of solid dosage forms
    Fluid bed granulation
    Credit test, Laboratory skills testing
Literature
    required literature
  • KUBOVÁ, Kateřina, Aleš FRANC, Jan GAJDZIOK, Martina KEJDUŠOVÁ and David VETCHÝ. Medical forms and biopharmacy - I. Liquid and Semi-Solid Dosage Forms. 1st ed. Brno: Farmaceutická fakulta Veterinární a farmaceutické univerzity, 2014, 125 pp. ISBN 978-80-7305-671-1. URL info
  • KUBOVÁ, Kateřina, Aleš FRANC, Jan GAJDZIOK, Martina KEJDUŠOVÁ and David VETCHÝ. Medical forms and biopharmacy - II. Solid Dosage Forms. Brno: Farmaceutická fakulta Veterinární a farmaceutické univerzity, 2014, 87 pp. skripta. ISBN 978-80-7305-757-2. URL info
  • The texts which are available during the lectures. info
    recommended literature
  • European Pharmacopoeia 11
  • MAHATO, Ram I. Pharmaceutical dosage forms and drug delivery. Boca Raton, FL: CRC Press, 2007, xxxi, 300. ISBN 0849392853. info
  • Aqueous polymeric coatings for pharmaceutical dosage forms. Edited by Linda A. Felton. Fourth edition. Boca Raton, FL: CRC Press, 2017, 1 online. ISBN 9781315369938. URL info
  • Handbook of Pharmaceutical Excipients. Great Britain, 2006. ISBN 1-58212-058-7. info
Teaching methods
1Lectures - powerpoint presentations
2 Individual lab training - practical skills
Assessment methods
Intermediate tests in laboratory classes
Systematic observation of the student during laboratory classes, preparation of reports following the teacher's instructions
Credit test (credit test has two parts, part 1 - pharmaceutical calculations (limit for passing 75%), part 2 - test - closed and open questions from knowledge from lectures and laboratory classes (limit for passing - 60%).
Practical testing is conducted to evaluate students' skills as part of the credit assessment.
Oral examination (study topics are available in the study materials in IS MU)
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
Teacher's information
Lectures are recommended due to the lack of suitable literature. Students can study this course only after completing the course Dosage Forms and Biopharmacy I
All study materials are available in IS MU.
The course is also listed under the following terms Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024.
  • Enrolment Statistics (Spring 2025, recent)
  • Permalink: https://is.muni.cz/course/pharm/spring2025/FAFO2_13