FDTMU_FAF Mechanisms of Drug Release and Their Statistical Evaluation

Faculty of Pharmacy
Autumn 2023
Extent and Intensity
1/1/0. 25 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. PharmDr. Kateřina Kubová, Ph.D. (lecturer)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (lecturer)
Guaranteed by
doc. Mgr. Jan Muselík, Ph.D.
Faculty of Pharmacy
Prerequisites (in Czech)
FAKULTA(FaF)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Expanding the knowledge of the student focusing on in vitro and in vivo mechanisms of drug release and their statistical evaluation, obtained mainly from world databases containing knowledge from scientific publications especially of foreign research experts and institutions and increasing the ability of the student to process this knowledge into research texts focusing on the content of the study program.
Learning outcomes
After completing the course the student will:
- have theoretical knowledge in the field of dissolution testing - be able to interpret the dissolution profile of a drug from a dosage form - theoretically and practically master the use of mathematical models to infer the kinetics and mechanism of drug release - estimate the effect of polymer blends on drug release - be able to make sophisticated comparisons of dissociation profiles
Syllabus
  • Dissolution testing of drug forms
    Modeling and comparison of dissolution profiles
    Mathematical comparison of dissolution profiles
    The effect of polymer blends on the release profiles
    A simple equation for description of solute release - Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs
    Design and evaluation of matrix-based controlled release tablet
    Formulation study and drug release mechanism
    Drug release evaluation
Teaching methods
consultation with the teacher
Assessment methods
Oral examination
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught each semester.
Teacher's information
Teaching is by way of consultation.
Current literature will be sent to the student by the guarantor upon request.
The course is also listed under the following terms Spring 2020, Autumn 2020, Spring 2021, Autumn 2021, Spring 2022, Autumn 2022, Spring 2023, Spring 2024, Autumn 2024, Spring 2025.
  • Enrolment Statistics (Autumn 2023, recent)
  • Permalink: https://is.muni.cz/course/pharm/autumn2023/FDTMU_FAF