FaF:F1FO2_13 Medical Forms and Biopharmacy - Course Information

F1FO2_13 Medical Forms and Biopharmacy II

Extent and Intensity

3/6/0. 11 credit(s). Type of Completion: zk (examination).

Teacher(s)

doc. PharmDr. Aleš Franc, Ph.D. (lecturer)
doc. PharmDr. Jan Gajdziok, Ph.D. (lecturer)
doc. PharmDr. Kateřina Kubová, Ph.D. (lecturer)
doc. PharmDr. Ruta Masteiková, CSc. (lecturer)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (lecturer)
PharmDr. Jakub Vysloužil, Ph.D. (lecturer)
doc. PharmDr. Aleš Franc, Ph.D. (seminar tutor)
doc. PharmDr. Jan Gajdziok, Ph.D. (seminar tutor)
doc. PharmDr. Kateřina Kubová, Ph.D. (seminar tutor)
doc. PharmDr. Ruta Masteiková, CSc. (seminar tutor)
PharmDr. Miroslava Pavelková, Ph.D. (seminar tutor)
PharmDr. Jakub Vysloužil, Ph.D. (seminar tutor)

Guaranteed by

doc. PharmDr. Ruta Masteiková, CSc.
Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• Pharmacy (programme FaF, M-FARM)

Course objectives

One of the main obligatory pharmaceutical disciplines dealing with preparation, manufacturing and quality control of medicaments including technological procedures, equiment, excipients and appropriate analytical devices. It covers the influence of the application form on drug bioavailability.

Syllabus

• SYLLABUS OF LECTURES
  1. Rectal dosage forms - definition, classification, properties. Suppositories, excipients, preparation, quality evaluation.
  2. Vaginal dosage forms - definition, classification, properties, excipients, quality evaluation.
  3. Granules, basic granulation techniques and equipment. Quality evaluation of powders and granules.
  4. Tablets - classification, basic compression techniques. Excipients for tablets. Quality evaluation and use.
  5. Incompatibilities in semisolid and solid dosage forms.
  6. The principles of good manufacturing practice.
  7. Oral dosage forms with controlled drug release.
  8. Capsules - classification, production, excipients, quality evaluation and use.
  9. Coated products - classification, basic coating techniques, quality evaluation and use.
  10. Aerosols - definition, classification, properties. Basic types of inhalation systems. Excipients for aerosols. Quality evaluation and use.
  11. Transdermal preparations. Basic types of transdermal therapeutic systems. Excipients for transdermal preparations. Quality evaluation and use.
  12. Pharmaceutical packaging.
  13. Regulatory authorities evaluation of dosage forms.
  14. Development of new drugs from galenical perspective.
  
  PRACTICAL TRAINING
  1. Ointments. Preparation and evaluation.
  
  2. Creams. Preparation and evaluation.
  3. Pastes and gels. Preparation and evaluation.
  4. Rectal suppositories. Determination of base replacement coefficient, calculations, preparation of suppositories with known base replacement coefficient.
  5. Rectal suppositories. Experimental determination of base replacement coefficient. Preparation of suppositories with unknown base replacement coefficient.
  6. Vaginal dosage forms. Preparation and evaluation.
  7. Technological procedures in preparation of complicated prescriptions of semisolid dosage forms, powders and suppositories.
  8. Solving of incompatibilities in prescriptions on semisolid and solid dosage forms, powders and suppositories, preparations according to prescriptions.
  9. Alternative training.
  10. Production of tablets by direct compression.
  11. Production of tablets from granules prepared by wet granulation.
  12. Production of tablets from granules prepared by fluid bed granulation technique.
  13. Preparation of coated tablets in laboratory coater. Evaluation of solid dosage forms.
  14. Test and check training. Awarding credits.
  
  
  Emulsions. Preparation and evaluation.
  2. Suspensions. Preparation and evaluation.
  3. Creams. Preparation and evaluation.
  4. Pastes and gels. Preparation and evaluation.
  5. Rectal suppositories. Determination of base replacement coefficient, Coefficiet. Preparation of suppository with unknown base replacement coefficient.
  6. Vaginal dosage form. Preparation and evaluation.
  7. Calculations in pharmaceutical technology.
  8. Technological processes in preparation of difficult prescriptions
  9. Incompatibilities in liquid dosage forms.
  10. Incompatibilities in semisolid and solid dosage forms.
  11. Substitute practice.
  12. Test and revisory practice.
  13. Awarding credits.
  
  

Literature

required literature
• Český lékopis - platné vydání a doplňky. info
• Komárek, P., Rabišková, M. Technologie léků. Galén, Praha, 2006. ISBN 80-7262-423-7. info

not specified
• Česká a slovenská farmacie. info
• Zathurecký, L., Chalabala, M., Janků, I., Modr., Z. Biofarmácia a farmakokinetika. Osveta Martin, 1989. ISBN 80-217-0068-8. info
• Chalabala, M., Heinrich, J. Základy výroby a tvorby liekov. Osveta Martin, 1988. info

Language of instruction

Czech

Further comments (probably available only in Czech)

The course can also be completed outside the examination period.

• Enrolment Statistics (Spring 2020, recent)
  
• Permalink: https://is.muni.cz/course/pharm/spring2020/F1FO2_13