F1GE1_16 Applied Genetics

Faculty of Pharmacy
Spring 2022
Extent and Intensity
2/0/0. 2 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. MVDr. RNDr. Petr Hořín, CSc. (lecturer)
doc. RNDr. Petra Bořilová Linhartová, Ph.D., MBA (lecturer)
PharmDr. Mgr. Alžběta Kružicová, Ph.D. (lecturer)
Mgr. Marie Klumplerová, Ph.D. (lecturer)
Guaranteed by
prof. MVDr. RNDr. Petr Hořín, CSc.
Department of Molecular Pharmacy – Departments – Faculty of Pharmacy
Timetable
Mon 14:55–16:35 44-037
Prerequisites
Basic knowledge of biology, biochemistry and genetics corresponding to the 1st year of the faculty´s programme.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.

The capacity limit for the course is 50 student(s).
Current registration and enrolment status: enrolled: 14/50, only registered: 0/50
fields of study / plans the course is directly associated with
Course objectives
Theoretical principles and practical applications of genetics in pharmacy are taught. Special attention is paid to genomics and its importance for new drug development, to genetics of disease, geentics of host and pathogen interactions, genetic variability in reactions to pharmacotherapy. Genetics of laboratory animals represents a special topic of the course.
Learning outcomes
Students will be able to use the acquired knowledge in related curricular subjects and eventually, they will be able to use it in understanding principles of drug action and in interpreting them for themselves and for their clients.
Syllabus
  • 1. Genome and its structure. Microbiome and its importance for pharmacy.Genetic polymorphism: definition, origins, types and practical applications in biomedicine. 2. Gene and methods of its identification. Genetics of qualitative and quantitative traits, methods of their analysis; applications in biomedicine. 3. Application of genetics in pharmacy: pharmacogenetics, important pharmacogenetic polymorphisms and applications in pharmacotherapy. 4. Genomics and its applications in pharmacy: pharmacogenomics, development of new drugs, precision medicine. 5. Mutations and mutagens. Types of mutations, their consequences. Mutagens in the environment. Drugs as potential mutagens. 6. Drugs in pregnancy from the genetic perspective. 7. Inherited disease in humans: Mendelian and non-Mendelian diseases. Human monogeneic diseases: modes of inheritance. 8. Inherited disease in humans: complex diseases and their genetic analysis. 9. Inherited disease in humans: genetic counselling, genetic diagnostics, prenatal and preimplantation diagnostics. 10. Oncogenetics: principles and applications. 11. Genetic susceptibility to disease, importance for precision medicine. 12. Human immunogenetics and its applications. Vaccinomics and genetics of vaccination. 13. Genetics of laboratory animals.
Literature
    recommended literature
  • Alberts et al.: Základy buněčné biologie. 2001, Espero Publishing, Ústí nad Labem.Nečas O a kol.: Obecná biologie. 2000, H a H, Jinočany.Šmarda J.: Genetika pro gymnázia. 2003, Fortuna Praha. info
Teaching methods
Interactive lectures.
Assessment methods
Oral examinations. Assessment criteria: capability to present an overview of a topic in a structured way, capability to explain its principles and a minimal factographic knowledge neede for complying with the previous criteria.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
Teacher's information
There are no practicals scheduled for the course. Attendance to the lectures is not compulsory; the only requirement is the corresponding level of knowledge at the oral exam.
The course is also listed under the following terms Spring 2020, Spring 2021, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2022, recent)
  • Permalink: https://is.muni.cz/course/pharm/spring2022/F1GE1_16