F1SU1_13 Physical Chemistry

Faculty of Pharmacy
Spring 2022
Extent and Intensity
2/2/0. 6 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. Mgr. Jan Muselík, Ph.D. (lecturer)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (lecturer)
PharmDr. Tomáš Bílik (seminar tutor)
Mgr. Jan Macků (seminar tutor)
doc. Mgr. Jan Muselík, Ph.D. (seminar tutor)
Mgr. Sylvie Pavloková, Ph.D. (seminar tutor)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (seminar tutor)
PharmDr. Jiří Zeman, Ph.D. (seminar tutor)
Guaranteed by
prof. PharmDr. Mgr. David Vetchý, Ph.D.
Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Timetable
Mon 11:15–12:55 45-135
  • Timetable of Seminar Groups:
F1SU1_13/01: Tue 15. 2. to Tue 1. 3. each odd Tuesday 12:45–16:05 18-122, Tue 15. 3. to Tue 12. 4. each odd Tuesday 12:45–13:35 18-122, each odd Tuesday 13:35–16:05 18-138, Tue 26. 4. to Tue 10. 5. each odd Tuesday 12:45–16:05 18-122, T. Bílik, J. Muselík
F1SU1_13/02: Tue 22. 2. to Tue 8. 3. each even Tuesday 12:45–16:05 18-122, Tue 22. 3. to Tue 19. 4. each even Tuesday 12:45–13:35 18-122, each even Tuesday 13:35–16:05 18-138, Tue 3. 5. to Tue 17. 5. each even Tuesday 12:45–16:05 18-122, S. Pavloková
F1SU1_13/03: Tue 15. 2. to Tue 1. 3. each odd Tuesday 16:20–19:40 18-122, Tue 15. 3. to Tue 12. 4. each odd Tuesday 16:20–17:10 18-122, each odd Tuesday 17:10–19:40 18-138, Tue 26. 4. to Tue 10. 5. each odd Tuesday 16:20–19:40 18-122, J. Macků
F1SU1_13/04: Tue 22. 2. to Tue 8. 3. each even Tuesday 16:20–19:40 18-122, Tue 22. 3. to Tue 19. 4. each even Tuesday 16:20–17:10 18-122, each even Tuesday 17:10–19:40 18-138, Tue 3. 5. to Tue 17. 5. each even Tuesday 16:20–19:40 18-122, J. Macků
F1SU1_13/05: Fri 18. 2. to Fri 4. 3. each odd Friday 7:30–10:50 18-122, Fri 18. 3. to Fri 29. 4. each odd Friday 7:30–8:20 18-122, each odd Friday 8:20–10:50 18-138, Fri 13. 5. each odd Friday 7:30–10:50 18-122, J. Zeman
F1SU1_13/06: Fri 25. 2. to Fri 11. 3. each even Friday 7:30–10:50 18-122, Fri 25. 3. to Fri 22. 4. each even Friday 7:30–8:20 18-122, each even Friday 8:20–10:50 18-138, Fri 6. 5. to Fri 20. 5. each even Friday 7:30–10:50 18-122, J. Zeman
F1SU1_13/07: Fri 18. 2. to Fri 4. 3. each odd Friday 13:15–16:35 18-122, Fri 18. 3. to Fri 29. 4. each odd Friday 13:15–14:05 18-122, each odd Friday 14:05–16:35 18-138, Fri 13. 5. each odd Friday 13:15–16:35 18-122, T. Bílik
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 175 student(s).
Current registration and enrolment status: enrolled: 119/175, only registered: 0/175, only registered with preference (fields directly associated with the programme): 0/175
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to make students familiar with basic knowledge of the physical chemistry, which constitutes part of the theoretical basis, necessary for understanding of processes delivered within disciplines in further stages of the study. Lectures are divided according to basic part of physical and colloid chemistry such as thermodynamics, kinetics of chemical reactions, behaviour of solutions, electrochemistry, phase equilibria, behaviour of phase interfaces, rheology, and colloidal systems. In laboratory exercises, students will learn the experimental techniques of physical chemistry. In seminars, students will get acquainted with physicochemical calculations, which are integral part of the knowledge required in the discipline.
Learning outcomes
After completing the course, the student will be able to:
– describe the thermodynamic nature of a number of pharmaceutical processes;
– describe the factors that influence the solubility and dissolution of substances;
– determine and describe kinetic parameters in pharmaceutical processes;
– identify and summarize important features of electrochemical and phase phenomena;
– apply rheological principles to a practical problem;
– identify and summarize important characteristics of colloidal systems.
Syllabus
  • LECTURES:
  • Thermodynamics.
  • Solubility: solubility gas/liquid, liquid/liquid, solid/liquid, solubility of salts, poor soluble electrolytes, weak electrolytes and their salts.
  • Electrochemistry.
  • Phase equilibria.
  • Phase interfaces.
  • Diffusion, dissolution and their importance in drug development.
  • Kinetics: rates and orders of reactions. Influence of temperature and other factors on reaction rates. The importance of kinetics in formulation and development of pharmaceuticals.
  • Rheology: Newtonian systems, non-Newtonian systems, thixotropy, determination of rheologic properties, viscoelasticity, application in pharmacy.
  • Colloids.

  • SEMINARS:
  • States of matter and thermodynamics – calculations.
  • Phase equilibria, chemical kinetics and electrochemistry – calculations.

  • LABORATORY EXERCISES:
  • Density determination by pycnometric method.
  • Partitioning of succinic acid in the system butanol-water.
  • Determination of upper critical dissolution temperature of the mixture phenol-water.
  • Credit tests.
Literature
    recommended literature
  • Atkins, P.W. Physical Chemistry. Oxford Univ.Press, Oxford, 1997. info
  • Kišová, L. , Trnková, L. Příklady z fyzikální chemie. PřF MU Brno, 1993. info
  • Fischer, O. a kol. Fyzikální chemie. SPN Praha, 1983. info
  • Vodrážka, Z. Fyzikální chemie pro biologické vědy. Academia, Praha, 1983. info
  • Moore, W.J. Fyzikální chemie. SNTL, Praha, 1979. info
  • Brdička, R., Dvořák, J. Základy fyzikální chemie. Academia, 1977. info
Teaching methods
lectures, seminars, laboratory exercises
Assessment methods
credit, written exam
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
Teacher's information
Participate in seminars and laboratory exercises in the full range given by the syllabus, properly write protocols from laboratory exercises. Demonstrate ongoing knowledge during seminars and laboratory exercises. Part of the credit is a written test for calculations and a test of knowledge of the content of laboratory exercises. The condition for participation in the exam is to receive a credit.
The course is also listed under the following terms Spring 2020, Spring 2021, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2022, recent)
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