FaF:FDCOC_FAF Organic Chemistry - Course Information
FDCOC_FAF Organic Chemistry
Faculty of PharmacySpring 2024
- Extent and Intensity
- 1/1/0. 25 credit(s). Type of Completion: zk (examination).
- Teacher(s)
- doc. Ing. Pavel Bobáľ, CSc. (lecturer)
- Guaranteed by
- doc. Ing. Pavel Bobáľ, CSc.
Faculty of Pharmacy - Prerequisites
- FAKULTA(FaF)
The knowledge of basics of inorganic chemistry. - Course Enrolment Limitations
- The course is only offered to the students of the study fields the course is directly associated with.
- fields of study / plans the course is directly associated with
- Medicinal Chemistry (programme FaF, D-FCH) (2)
- Course objectives
- Organic chemistry gives students information about the fundamentals of organic compounds structure, their reactions, and the underlying reaction mechanism. Organic chemistry is essential for many other disciplines, such as biochemistry, analytical chemistry, pharmaceutical chemistry, physiology, pharmacology and other health and biological studies. Close attention is paid to the interrelation between organic chemistry and these disciplines.
- Learning outcomes
- Understanding of organic chemistry, understanding of structure and reactivity of organic compounds, knowledge of the basis of IUPAC nomenclature of organic compounds and principals of stereochemistry.
- Syllabus
- 1. What is organic chemistry?
2. Organic structures
3. Determining organic structures
4. Structure of molecules
5. Organic reactions
6. Nucleophilic addition to the carbonyl group
7. Delocalization and conjugation
8. Acidity, basicity, and pKa
9. Using organometallic reagents to make C-C bonds
10. Nucleophilic substitution at the carbonyl group
11. Nucleophilic substitution at C=O with loss of carbonyl oxygen
12. Equilibria, rates, and mechanisms
13. 1H NMR: Proton nuclear magnetic resonance
14. Stereochemistry
15. Nucleophilic substitution at saturated carbon
16. Conformational analysis
17. Elimination reactions
18. Review of spectroscopic methods
19. Electrophilic addition to alkenes
20. Formation and reactions of enols and enolates
21. Electrophilic aromatic substitution
22. Conjugate addition and nucleophilic aromatic substitution
23. Chemoselectivity and protecting groups
24. Regioselectivity
25. Alkylation of enolates
26. Reactions of enolates with carbonyl compounds: the aldol and Claisen
reactions
27. Sulfur, silicon, and phosphorus in organic chemistry
28. Retrosynthetic analysis
29. Aromatic heterocycles 1: reactions
30. Aromatic heterocycles 2: synthesis
31. Saturated heterocycles and stereoelectronics
32. Stereoselectivity in cyclic molecules
33. Diastereoselectivity
34. Pericyclic reactions 1: cycloadditions
35. Pericyclic reactions 2: sigmatropic and electrocyclic reactions
36. Participation, rearrangement, and fragmentation
37. Radical reactions
38. Synthesis and reactions of carbenes
39. Determining reaction mechanisms
40. Organometallic chemistry
41. Asymmetric synthesis
42. Organic chemistry of life
43. Organic chemistry today
- 1. What is organic chemistry?
- Literature
- required literature
- Jonathan Clayden. Organic Chemistry. Oxford University Press, 2012. ISBN 9780199270293. info
- Teaching methods
- Dialogic (discussion, interview, brainstorming)
Demonstration - Assessment methods
- Oral examination
- Language of instruction
- Czech
- Further comments (probably available only in Czech)
- The course can also be completed outside the examination period.
The course is taught each semester. - Teacher's information
- Mastering fundamentals of and advanced organic chemistry
Consultation with the teacher
Practical application of acquired knowledge
The course is done using self-studies, personal communication, and consultations with the lecturer
- Enrolment Statistics (Spring 2024, recent)
- Permalink: https://is.muni.cz/course/pharm/spring2024/FDCOC_FAF