FDCOC_FAF Organic Chemistry

Faculty of Pharmacy
Spring 2025
Extent and Intensity
1/1/0. 25 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. Ing. Pavel Bobáľ, CSc. (lecturer)
Guaranteed by
doc. Ing. Pavel Bobáľ, CSc.
Faculty of Pharmacy
Prerequisites
FAKULTA(FaF)
The knowledge of basics of inorganic chemistry.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Organic chemistry gives students information about the fundamentals of organic compounds structure, their reactions, and the underlying reaction mechanism. Organic chemistry is essential for many other disciplines, such as biochemistry, analytical chemistry, pharmaceutical chemistry, physiology, pharmacology and other health and biological studies. Close attention is paid to the interrelation between organic chemistry and these disciplines.
Learning outcomes
Understanding of organic chemistry, understanding of structure and reactivity of organic compounds, knowledge of the basis of IUPAC nomenclature of organic compounds and principals of stereochemistry.
Syllabus
  • 1. What is organic chemistry?
    2. Organic structures
    3. Determining organic structures
    4. Structure of molecules
    5. Organic reactions
    6. Nucleophilic addition to the carbonyl group
    7. Delocalization and conjugation
    8. Acidity, basicity, and pKa
    9. Using organometallic reagents to make C-C bonds
    10. Nucleophilic substitution at the carbonyl group
    11. Nucleophilic substitution at C=O with loss of carbonyl oxygen
    12. Equilibria, rates, and mechanisms
    13. 1H NMR: Proton nuclear magnetic resonance
    14. Stereochemistry
    15. Nucleophilic substitution at saturated carbon
    16. Conformational analysis
    17. Elimination reactions
    18. Review of spectroscopic methods
    19. Electrophilic addition to alkenes
    20. Formation and reactions of enols and enolates
    21. Electrophilic aromatic substitution
    22. Conjugate addition and nucleophilic aromatic substitution
    23. Chemoselectivity and protecting groups
    24. Regioselectivity
    25. Alkylation of enolates
    26. Reactions of enolates with carbonyl compounds: the aldol and Claisen
    reactions
    27. Sulfur, silicon, and phosphorus in organic chemistry
    28. Retrosynthetic analysis
    29. Aromatic heterocycles 1: reactions
    30. Aromatic heterocycles 2: synthesis
    31. Saturated heterocycles and stereoelectronics
    32. Stereoselectivity in cyclic molecules
    33. Diastereoselectivity
    34. Pericyclic reactions 1: cycloadditions
    35. Pericyclic reactions 2: sigmatropic and electrocyclic reactions
    36. Participation, rearrangement, and fragmentation
    37. Radical reactions
    38. Synthesis and reactions of carbenes
    39. Determining reaction mechanisms
    40. Organometallic chemistry
    41. Asymmetric synthesis
    42. Organic chemistry of life
    43. Organic chemistry today
Literature
    required literature
  • Jonathan Clayden. Organic Chemistry. Oxford University Press, 2012. ISBN 9780199270293. info
Teaching methods
Dialogic (discussion, interview, brainstorming)
Demonstration
Assessment methods
Oral examination
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught each semester.
Teacher's information
Mastering fundamentals of and advanced organic chemistry
Consultation with the teacher
Practical application of acquired knowledge
The course is done using self-studies, personal communication, and consultations with the lecturer
The course is also listed under the following terms Spring 2020, Autumn 2020, Spring 2021, Autumn 2021, Spring 2022, Autumn 2022, Spring 2023, Autumn 2023, Spring 2024, Autumn 2024.
  • Enrolment Statistics (Spring 2025, recent)
  • Permalink: https://is.muni.cz/course/pharm/spring2025/FDCOC_FAF