Bi9901 Free radicals in biology.

Faculty of Science
Autumn 2002
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Milan Číž, Ph.D. (lecturer), doc. RNDr. Martin Vácha, Ph.D. (deputy)
doc. RNDr. Antonín Lojek, CSc. (lecturer), doc. RNDr. Martin Vácha, Ph.D. (deputy)
Guaranteed by
prof. RNDr. Vladimír Šimek, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Vladimír Šimek, CSc.
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives
Biology of oxygen (Oxygen and evolution of life on Earth; Oxygen cycle in nature; Photosynthesis; Respiratory chain). Chemistry of free radicals (Reactive oxygen species; Role of transition metal ions; Nitric oxide and derived molecules). Sources of free radicals (Endogenous physiological or pathological processes: Leak of electrons from metabolic pathways, Peroxisomes, Xanthine/xanthine oxidase, Metabolism of arachidonic acid, Autooxidation of catechols and flavonoids; Exogenous sources, Food constituents, Drugs, UV irradiation, Ionising irradiation, Polluted environment). Physiology of free radicals (Phagocytosis; NADPH oxidase of professional phagocytes; Microbicidal mechanisms based on oxygen; Chronic granulomatous disease (CGD); Gene regulation; Apoptosis; Oxidative burst in plants as defence mechanism against infection). Role of free radicals in diseases (Lipid peroxidation; Protein degradation; DNA damage; Regulation of oxidative stress). Defence against free radicals (Prevention of free radical generation; Compartmentalisation of free radicals; Free radical scavengers; Antioxidant defence and damage repair; Antioxidant pharmacological intervention). Pathology of free radicals (Oxidative stress and aging; Reproduction; Ischemia-reperfusion injury; Inflammation; Atherosclerosis; Brain dysfunction; Cancer; Myocarditis; Diabetes mellitus; Eye diseases; Adult respiratory distress syndrome (ARDS); Oxidative injury to lungs induced by xenobiotics; Radiation injury; Rheumatoid arthritis; Skin injury). Methods of oxidative damage evaluation (Detection of free radicals; Evaluation of antioxidant activity of biological samples; Determination of damage to biological macromolecules).
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2010, Autumn 2011 - acreditation, Autumn 2012, Autumn 2014, Autumn 2016, Autumn 2018, Autumn 2020, Autumn 2022, Autumn 2024.
  • Enrolment Statistics (Autumn 2002, recent)
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