Bi5220 Immunology

Faculty of Science
Autumn 2008
Extent and Intensity
2/0/0. 2 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: graded credit.
Teacher(s)
doc. RNDr. Antonín Lojek, CSc. (lecturer)
doc. RNDr. Milan Číž, Ph.D. (lecturer)
doc. Mgr. Lukáš Kubala, Ph.D. (lecturer)
Guaranteed by
doc. RNDr. Antonín Lojek, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: doc. RNDr. Antonín Lojek, CSc.
Timetable
Tue 8:00–9:50 A,01026
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The lecture is focused on: cells and organs of the immune system, mechanisms of nonspecific immunity (inflammation, complement, phagocytes), antigens (structure, chemical properties, classification, presentation), antibodies (structure, chemical properties, functions, classes of antibodies, isotypes, allotypes, idiotypes), major histocompatibility complex, reactions of the antigens and antibodies, immunoregulation (cytokines, surface molecules), mechanisms of antiinfection immunity, basic knowledge in immunopathology and immunotoxicology including transplantation and cancer immunology.
Syllabus
  • 1. Introduction to immunobiology. 2.Cells and organs of the immunity - ontogenesis, phenotype, structure, function and activacion, signals receptors: 3.Immune response: antigens, structure, chemical properties, classification, presentation MHC structure, function, regulation, immunogenetics: genes displacement, polymorphism, genesis of diversity Antibodies: structure, chemical properties, functions, classes of antibodies, isotypes, allotypes, idiotypes T-cell receptors: structure, function and antigen binding, interaction of receptors with ligands: adhesive molecules, complement receptors, Fc receptors, transfer of signals Nonspecific immunity: complement: structure and function, accute phasis reactans, inflammation Phagocytosis: phases, cooperation of the phagocytosis with other components of the immune system 4.The mechanism of the hypersensitivity: IgE mediated / early and late response; IgG, IgA and IgM mediated; immune complexes mediated; cell mediated. 5. Cytokines and immunomodulators: cytokines: properties, origin, structure, effect, receptor-place of effect, metabolism, regulation and gene activation. Inflammatory mediators: origin, structure, effect, receptor-place of effect, metabolism and regulation 6.Immunoregulation: toleration, clonal selection, inhibition, antigenic paralytic intracellular - interaction: help and inhibition (suppresion). Idiotype network: inhibition and stimulation. Mechanisms of auto-immunity 7. Antiinfection immunity: immunity against viruses, bacteria, fungi, parasites. 8. Failures of host defence mechanisms, primary and secondary immunodeficiencies. 9. Immunity and cancer, transplantation immunology, immunotoxicology 10.Immunomodulation 11. Methods used in immunology.
Literature
  • HOŘEJŠÍ, Václav and Jiřina BARTŮŇKOVÁ. Základy imunologie. 2.vyd. Praha: Triton, 2002, 260 pp. ISBN 80-7254-215-X. info
  • TOMAN, Miroslav. Veterinární imunologie. 1. vyd. Praha: Grada, 2000, 413 s. ISBN 8071697273. info
  • Immunobiology : the immune system in health and disease. Edited by Charles Janeway. 6th ed. New York, N.Y.: Garland Science, Taylor & Francis Group, 2005, xxiii, 823. ISBN 0815341016. info
  • KREJSEK, Jan and Otakar KOPECKÝ. Klinická imunologie. 1. vyd. Hradec Králové: NUCLEUS HK, 2004, 941 s. ISBN 808622550X. info
Assessment methods
Lectures. Written examination.
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.
  • Enrolment Statistics (Autumn 2008, recent)
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