PřF:Bi7070 Physiology of Cell Systems - Course Information

Bi7070 Physiology of Cell Systems

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Alois Kozubík, CSc. (lecturer)
prof. RNDr. Jiřina Hofmanová, CSc. (lecturer)

Guaranteed by

prof. RNDr. Alois Kozubík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Alois Kozubík, CSc.

Timetable

Wed 14:00–15:50 BFU

Prerequisites

Basic knowledge of biochemistry, cell and molecular biology are neccessary

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

there are 6 fields of study the course is directly associated with, display

Course objectives

Complex course is aimed at a deeper understanding of cell functions, development and control of cytokinetics (proliferation, differentiation and apoptosis), and the mechanisms of action of hormones, cytokines and other regulatory molecules. A special attention is paid to the processes taking place at the level of plasmatic membrane, cytosol and nucleus, i.e. signal transduction at the molecular level. The information provided should help to understand the feedback mechanisms and the outcomes of disruptions of cellular regulation in the whole organism - reactions such as stress, inflammation, carcinogenesis. This is aimed to knowledge of mutual relationships on various regulation levels of mammalian organism (from molecules to the whole system).

Syllabus

• 1. Introduction to theory of the systems 2. Cell population types 3. Regulation of cytokinetics Cell cycle and its regulation Growth stimulators and inhibitors 4. Structure and function of cell membranes Lipid mediators and cytokines Signal transduction and expression of genetic information Hematopoietic system and its functions Membrane recognition and immune systems 6. Homeostasis, health and disease Organism as hierarchic systém Cooperation of nervous, endocrine and humoral systems 7. Harmful environmental factors and human health risk

Literature

• ALBERTS, Bruce. Základy buněčné biologie : úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2004, xxvi, 630. ISBN 8090290620. info
• ALBERTS, Bruce. Molecular biology of the cell. 3rd ed. New York: Garland Publishing, Inc., 1994, xliii, 129. ISBN 0-8153-1620-8. info
• Cell Physiology Source Book, ed. N. Sperelakis, Academic Press Inc., 1995
• TROJAN, Stanislav. Lékařská fyziologie. Vyd. 3., dopl. a rozš. Praha: Grada, 1999, 612 s. ISBN 8071697885. info
• VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info
• The cytokine handbook, ed. A. W. Thompson, Academic Press New York, 1994
• Functional metabolism, Regulation and Adaptation, ed. K. B. Storey, Wiley-Liss, Inc., Hoboken, New Jersey, 2004
• Handbook of cell signaling, Vol. 1, 2, 3, eds. R. A. Bradshaw, E. A. Dennis, Academic Press, Elsevier Science 2004
• ŠTERZL, Jaroslav. Imunitní systém a jeho fyziologické funkce. Praha: Česká imunologická společnost, 1993, 480 s. info
• KOTYK, Arnošt. Struktura a funkce biomembrán. 1. vyd. Brno: Masarykova univerzita, 1996, 173 s. ISBN 8021013168. info
• + doporučené speciální separáty a schemata z přednášek

Assessment methods

Lectures
final written exam

Language of instruction

Czech

Follow-Up Courses

• C6870 Health Risks
• C8630 Genotoxicity and Carcinogenesis

Further Comments

Study Materials
The course can also be completed outside the examination period.
The course is taught annually.

Listed among pre-requisites of other courses

• Bi8110 Mechanisms of carcinogenesis
  Bi7070  

• Enrolment Statistics (Autumn 2008, recent)
  
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