Bi5220 Immunology

Faculty of Science
Autumn 2019
Extent and Intensity
2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Milan Číž, Ph.D. (lecturer)
doc. Mgr. Lukáš Kubala, Ph.D. (lecturer)
doc. RNDr. Antonín Lojek, CSc. (alternate examiner)
Guaranteed by
doc. Mgr. Lukáš Kubala, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: doc. Mgr. Lukáš Kubala, Ph.D.
Supplier department: Department of Experimental Biology – Biology Section – Faculty of Science
Timetable
Mon 12:00–13:50 B22/116 aula
Prerequisites (in Czech)
! Bi5220en Immunology && !NOWANY( Bi5220en Immunology )
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course students should be able to:
understand basic principles of immunology;
explain principles of immune response, immunoregulation, and immunomodulation;
differentiate mechanisms of hypersensitivity;
define the role of cytokines and immunomodulators;
explain mechanisms of anti-infection immunity.
Learning outcomes
Student will be able to:
- to identify and describe the individual components of the immune system of humans and selected mammals;
- to describe the functions of cellular immune response;
- to describe the functions of the humoral immune response;
- to compare and highlight differences in non-specific and specific immune response;
- to compare and highlight differences in the principles of immune response to various pathogens and damaged or altered own cells;
- to describe current scientific knowledge in the field of pathological disorders of the immune system;
Syllabus
  • 1. Introduction to immunobiology. 2.Cells and organs of the immunity - ontogenesis, phenotype, structure, function and activation, signal receptors: 3.Immune response: antigens, structure, chemical properties, classification, presentation, MHC structure, function, regulation, immunogenetics: gene displacement, polymorphism, genesis of diversity Antibodies: structure, chemical properties, functions, classes of antibodies, isotypes, allotypes, idiotypes T-cell receptors: structure, function and antigen binding, interaction of receptors with ligands: adhesive molecules, complement receptors, Fc receptors, transfer of signals Nonspecific immunity: complement: structure and function, acute phase reactants, inflammation Phagocytosis: phases, cooperation of the phagocytosis with other components of the immune system 4.The mechanism of the hypersensitivity: IgE mediated / early and late response; IgG, IgA and IgM mediated; immune complexes mediated; cell mediated. 5. Cytokines and immunomodulators: cytokines: properties, origin, structure, effect, receptor-place of effect, metabolism, regulation and gene activation. Inflammatory mediators: origin, structure, effect, receptor-place of effect, metabolism and regulation 6.Immunoregulation: toleration, clonal selection, inhibition, antigenic paralytic intracellular - interaction: help and inhibition (suppression). Idiotype network: inhibition and stimulation. Mechanisms of auto-immunity 7. Antiinfection immunity: immunity against viruses, bacteria, fungi, parasites. 8. Failures of host defence mechanisms, primary and secondary immunodeficiencies. 9. Immunity and cancer, transplantation immunology, immunotoxicology 10.Immunomodulation 11. Methods used in immunology.
Literature
  • Immunobiology : the immune system in health and disease. Edited by Charles Janeway. 6th ed. New York, N.Y.: Garland Science, Taylor & Francis Group, 2005, xxiii, 823. ISBN 0815341016. info
  • HOŘEJŠÍ, Václav and Jiřina BARTŮŇKOVÁ. Základy imunologie. 2.vyd. Praha: Triton, 2002, 260 pp. ISBN 80-7254-215-X. info
  • TOMAN, Miroslav. Veterinární imunologie. 1. vyd. Praha: Grada, 2000, 413 s. ISBN 8071697273. info
  • KREJSEK, Jan and Otakar KOPECKÝ. Klinická imunologie. 1. vyd. Hradec Králové: NUCLEUS HK, 2004, 941 s. ISBN 808622550X. info
Teaching methods
Lectures and presentations by specialists in the individual sectors of immunology.
Assessment methods
Written examination which consists of 12 questions. It is necessary to obtain at least 16 points (maximum 30 points) for successful passing.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on course enrolment limitations: Na předmět se vztahuje povinnost registrace, bez registrace může být znemožněn zápis předmětu!
Listed among pre-requisites of other courses

Zobrazit další předměty

The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.
  • Enrolment Statistics (Autumn 2019, recent)
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