C3210 Structural bioinformatics

Faculty of Science
Autumn 2020
Extent and Intensity
1/0/0. 1 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
Teacher(s)
prof. RNDr. Jaroslav Koča, DrSc. (lecturer)
Mgr. Martin Prokop, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Jaroslav Koča, DrSc.
National Centre for Biomolecular Research – Faculty of Science
Supplier department: National Centre for Biomolecular Research – Faculty of Science
Timetable
Thu 16:00–16:50 C04/211
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to introduce students to the problem of structural motives of proteins and nucleic acids, to methods for 3D protein structure determination, to physical-chemical principles of protein interactions and application of this knowledge for design of biologically active molecules.
Learning outcomes
On successful completion of the course, a learner will be able to: describe basic structural motives in proteins and nucleic acids; describe theoretical principles of methods for 3D structure prediction of proteins; interpret relationship between 3D structure and biological function; illustrate practical applicability of the principles for design of biologically active molecules.
Syllabus
  • 1.What is structural bioinformatics ? 2.How to obtain 3-D structure? 3.Basic structural motives in proteins, protein structure. 4.Basic structural motives in nucleic acids. Nucleic acids structure. 5.Energy as a key to predict 3-D structure. 6.Molecular mechanics. 7.Conformational analysis. 8.How to organize 3-D data in databases. 9.Homology modeling and „threading“ 10.Molecular complexes, docking. 11.Structural bioinformatics and biologically active compounds design. 12.Drug design based on receptor and pharmacophore.
Literature
  • Structural bioinformatics. Edited by Philip E. Bourne - Helge Weissig. Hoboken, N.J.: Wiley-Liss, 2003, xix, 649. ISBN 0471201995. info
Teaching methods
Theoretical lecture.
Assessment methods
Written test and oral examination. The test consists of 30 questions, 20 correct answers is needed to pass.
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.
  • Enrolment Statistics (Autumn 2020, recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2020/C3210