PřF:Bi6726 Fyziologie působení farmak a t - Course Information
Bi6726 Fyziologie působení farmak a toxických látek
Faculty of ScienceSpring 2006
- Extent and Intensity
- 2/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
- Teacher(s)
- prof. RNDr. Jan Vondráček, Ph.D. (lecturer), prof. RNDr. Alois Kozubík, CSc. (deputy)
RNDr. Miroslav Machala, CSc. (lecturer), prof. RNDr. Alois Kozubík, CSc. (deputy) - Guaranteed by
- prof. RNDr. Vladimír Šimek, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science - Timetable
- Thu 8:00–9:50 BFU
- Course Enrolment Limitations
- The course is offered to students of any study field.
- Course objectives (in Czech)
- Předmět má seznámit studenty s principy modulace fyziologických procesů v organismu prostřednictvím cizorodých látek. Cílem je propojit poznatky xenobiochemie, toxikologie a farmakologie s fyziologií tak, aby bylo moné rozířit poznatky studentů jak o mechanismech působení těchto látek, tak o důsledcích, které má narušení normálních fyziologických regulací pro ivočichy i jejich společenstva.
- Syllabus
- 1)An overview of chemical compounds that may disrupt normal physiological functions - anthropogenic organic pollutants, pharmaceuticals, secondary metabolites (dietary compounds and toxins); main exposure routes. 2)Basic principles of metabolization, transport and accmulation of xenobiotics within body, Phase I and II biotransformation enzymes; antioxidants;Phase III. proteins. 3)Basic types of toxicity of xenobiotics (genotoxicity, hepatotoxicity, neurotoxicity, immunotoxicity, tumor promotion, endocrine disruption). 4)Basic classes of pharmaceuticals, pharmacokinetics, toxic side-effects of pharmaceuticals; cytostatics, hormones, neuroleptic compounds. 5)Deregulation of signal transduction by xenobiotics. 6)bHLH/PAS protein family; HIF-1alpha, Ah receptor and its pathway; toxic effects of AhR ligands. 7)Nuclear receptors (ER, AR, PR, GR, TR, RAR/RXR, CAR, PXR, PPAR) their ligands; their role in regulation of metabolism; physiological functions based on modulation of target gene expression. 8)Biosynthesis and metabolism of endogenous NR ligands (steroids, fatty acids, lipid mediators); hormonal regulation of biosynthesis. 9)Principles of hormonal regulation and endocrine disruption in invertebrates. 10)Endocrine regulation and disruption in vertebrates: ER, AR, PR, GR. 11)Endocrine disruption and regulation of embryonalo and post-natal development of vertebrates: RAR, RXR, PPAR, TR. 12)Natural compounds; sources and chemoprotectivity.
- Language of instruction
- Czech
- Further Comments
- The course is taught annually.
- Enrolment Statistics (Spring 2006, recent)
- Permalink: https://is.muni.cz/course/sci/spring2006/Bi6726