PřF:Bi6930 Immunotoxicology - Course Information
Bi6930 Immunotoxicology
Faculty of ScienceSpring 2006
- Extent and Intensity
- 2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
- Teacher(s)
- prof. RNDr. Luděk Bláha, Ph.D. (lecturer)
- Guaranteed by
- prof. RNDr. Luděk Bláha, Ph.D.
RECETOX – Faculty of Science
Contact Person: prof. RNDr. Luděk Bláha, Ph.D. - Timetable
- Fri 13:00–14:50 kamenice
- Course Enrolment Limitations
- The course is also offered to the students of the fields other than those the course is directly associated with.
- fields of study / plans the course is directly associated with
- Ecotoxicology (programme PřF, M-BI)
- Course objectives
- Immunotoxicology - research branch studying effects of stressors (mainly chemical compounds) on immune system and the importance of immune system changes for organism health.. Immune system - components, function, communication. Experimental design in immunotoxicology. Tiered approach. Laboratory methods in immunotoxicology. Factors affecting immune system. Special immunotoxicology - drugs, pollutants. Ecological immunotoxicology - invertebrates, fish, amphibians. Risk assessment in immunotoxicology.
- Syllabus
- 1. Immunotoxicology. Introduction, history, aims and scopes, human immunotoxicology, ecological immunotoxicology. 2. Immune system. Components of immune system, function, communication, immune system as a target of xenobiotics. Immune system as a part of an organism - interactions, controls, homeostasis, (xeno-)estrogens. 3. Experimental design in immunotoxicology. Exposure, response. "Tier I" and "Tier II" methods. Animal models in immunotoxicology, batteries of immunotoxicology tests. 4. Laboratory methods in immunotoxicology. Assays of immunocompetence, macrophage function assays, host resistance, antitumor immunity, hypersensitivity, autoimmunity. 5. Special immunotoxicology 1 - introduction. Factors affecting immune system (climate, geography, biorhythms, stress, social habits, chemicals, irradiation and other physico-chemical factors). 6. Special immunotoxicology 2 - immunotoxicology of drugs (antibiotics, important pharamceuticals, immunosuppressives a immunomodulators, antitumor therapy). 7. Special immunotoxicology 3 - immunotoxicology of pollutants (metals, pesticides, industrial chemicals - PCBs, PAHs, PCDD(F)s, other organic pollutants, azbestosis, silikosis). 8. Ecological immunotoxicology. Animal immune system and interactions with xenobiotics. Invertebrates, fish, amphibians, birds, mammals. Markers of immune system alterations, ecological consequences. Case studies. 9. Risk assessment. Immunotoxicology as a branch of general toxicology, hazard identification, uncertainities.
- Literature
- Immunotoxicology and immunopharmacology. Edited by Jack H. Dean. 2nd ed. New York: Raven Press, 1994, xxi, 761 s. ISBN 0-7817-0219-4. info
- Wagner, V., Wagnerová, M. Ekoimunologie, Avicenum, 1988, Praha
- Ferenčík, M. Immunochémia, Alfa, 1989, Bratislava
- Language of instruction
- Czech
- Further Comments
- The course is taught annually.
- Enrolment Statistics (Spring 2006, recent)
- Permalink: https://is.muni.cz/course/sci/spring2006/Bi6930