PřF:C2021 Organic Chemistry I - Course Information
C2021 Organic Chemistry I
Faculty of ScienceSpring 2012
- Extent and Intensity
- 2/0/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
- Teacher(s)
- prof. RNDr. Milan Potáček, CSc. (lecturer)
RNDr. Slávka Janků, Ph.D. (seminar tutor)
Mgr. Jaromír Literák, Ph.D. (seminar tutor)
doc. Mgr. Kamil Paruch, Ph.D. (seminar tutor)
prof. Ing. Vladimír Šindelář, Ph.D. (seminar tutor) - Guaranteed by
- prof. RNDr. Milan Potáček, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science - Timetable
- Fri 8:00–9:50 B11/132
- Prerequisites
- ( C1020 General Chemistry || C1601 General and Inorg. Chemistry ) && ! NOW ( C2700 Basic Organic Chemistry )
Knowledge of General chemistry priciples - Course Enrolment Limitations
- The course is also offered to the students of the fields other than those the course is directly associated with.
- fields of study / plans the course is directly associated with
- there are 12 fields of study the course is directly associated with, display
- Course objectives
- Organic Chemistry I is giving an information on chemical nomenclature, structure of basic organic skeletons and their stereochemistry as well as their reactivity. After this course students are supposed to understand formation, stereochemistry and reactivity of basic hydrocarbon skeletons.
- Syllabus
- Organic chemistry I Organic chemistry of the basic hydrocarbon skeletons. The subject of organic chemistry. Chemical bonds and bonding in organic molecules. Hybridization of the carbon atom, bonding energy, bond length, polarity of the chemical bond. Inductive and mesomeric effects on the chemical bonds, conjugation. General criteria of chemical reaction - reaction kinetics, reaction profiles and mechanism. Activation energy and enthalpy of the reaction. Chemical nomenclature. Alkanes and cycloalkanes, their chemical nomenclature. Chain isomerie, conformation analysis of alkanes and cycloalkanes (with stress on cyclohexane ring). Fused cyclic systems. Newmann projection. cis-trans Isomerism of cycloalkanes. Radical reactions as typical reactions of this system. Summary of radical reactions. Optical activity and symmetry of molecules. Chiral molecules, conditions of chirality. Methods of space objects presentation. Enantiomers, optical activity, specific rotation and its measurement, optical purity, racemic mixture. Molecules with more than one stereocenter. Cahn, Ingold, Prelog rules. Nomenclature of enantiomers. Meso compounds. Resolution of enantiomers. Alkenes, stereochemistry of double bond, cis-trans and E-Z nomenclature. Addition reactions, their summary with attention to the stereochemistry and mechanism. Polymerizations. Dienes and polyenes (cumulated, isolated, conjugated). Reactions of conjugated dienes, conditions and mechanism of 1,2- and 1,4-addition. Isoprenoides (monoterpenes, sesquiterpenes, di-, tri- and tetraterpenes, carotenes). Electronic spectra and relation between the structure and its spectrum. Pericyclic reactions - electrocyclic reactions, cycloaddition reactions, the rules of their realization, sigmatropic rearrangements. Akynes and their structure. Properties of the triple bond, addition reactions (electrophilic and nucleophilic additions), acidity of the hydrogen atoms bound on sp- carbon, pK$_a$. The phenomenon of aromaticity and its properties. Nonbenzoid aromates (polycyclic aromates, annulenes, aromatic ions.} Mechanism of aromatic electrophilic substitution. Summary of electrophilic reactions, formation of electrophilic reagents. Effect of substituents on the reactivity and orientation. Hammet equation, sigma and rho constants. Ipso substitution. Nucleophilic substitution on the aromatic ring (SN1, SN2, elimination-addition mechanism). Conditions for addition reactions and reactions of oxidation. Substitution a other reactions on fused aromatic compounds.
- Literature
- Mc Murry: Organická chemie, překlad z originálu 6. vydání, 2004, vydáno VUT Brno-nakladatelství VUTIUM a VŠCHT Praha, listopad 2007.
- MCMURRY, John. Fundamentals of organic chemistry. 4th ed. Pacific Grove: Brooks/Cole publishing company, 1998, xxii, 566,. ISBN 0-534-35245-4. info
- POTÁČEK, Milan, Ctibor MAZAL and Slávka JANKŮ. Řešené příklady z organické chemie. 1st ed. Brno: Masarykova univerzita v Brně, 2000, 243 pp. ISBN 80-210-2274-4. info
- J. Clayden, N. Greeves, S. Warren, P. Wothers. Organic Chemistry. Oxford University Press 2001
- SOLOMONS, T. W. Graham. Organic chemistry. 6th ed. New York: John Wiley & Sons, 1996, xxvii, 121. ISBN 0471013420. info
- HRNČIAR, Pavol. Organická chémia. 3., preprac. vyd. Bratislava: Slovenské pedagogické nakladateľstvo, 1990, 708 s. ISBN 8008000287. info
- ČERVINKA, Otakar. Chemie organických sloučenin. 1. vyd. Praha: Státní nakladatelství technické literatury, 1985, 1131 s. info
- ČERVINKA, Otakar. Chemie organických sloučenin. Vyd. 1. Praha: Státní nakladatelství technické literatury, 1987, 1052 s. info
- NOVÁČEK, Eduard and Milan POTÁČEK. Laboratorní technika ke cvičení z metod organické chemie. Edited by Slávka Janků. 1. vyd. Brno: Masarykova univerzita, 1997, 91 s. ISBN 8021015004. info
- POTÁČEK, Milan. Organická chemie : pro biology. 1. vyd. Brno: Vydavatelství Masarykovy univerzity, 1995, 208 s. ISBN 8021011254. info
- Teaching methods
- lecture
- Assessment methods
- The course introduces into structure, stereochemistry and reactivity knowledge of the basic hydrocarbon skeletons. This knowledge is then tested in final written test and its successful passing is the condition for credits obtaining.
- Language of instruction
- Czech
- Follow-Up Courses
- Further comments (probably available only in Czech)
- Study Materials
The course is taught annually.
General note: Doporučuje se zapsat Speciální seminář z Organické chemie I. - Listed among pre-requisites of other courses
- C2022 Organic Chemistry I - Seminar
NOW(C2021)||C2021 - C2700 Principles of Organic Chemistry
(C1601||C1601bf||C1020) && !C2021 && !C3022 && !C3050 && !NOWANY(C2021,C3022,C3050) - C3050 Organic Chemistry II
C2021 - C7410 Structure and Reactivity
((C1020&&C2021&&(C3022||C3050)&&(C4660||C3140||C3401)&&(C4020||C4402))&&NOW(C7415))||souhlas - C8435 Heterocyclic compounds
C2021 && C3022 - C8780 Photochemistry: From Concepts to Practice
(C1020&&C2021&&C3022&&(C4660||C3140||C3401)&&(C4020||C4402))||souhlas
- C2022 Organic Chemistry I - Seminar
- Enrolment Statistics (Spring 2012, recent)
- Permalink: https://is.muni.cz/course/sci/spring2012/C2021