aVLBC0422s Biochemie II - seminář

Lékařská fakulta
jaro 2025
Rozsah
0/3/0. 45. 3 kr. Ukončení: z.
Vyučováno kontaktně
Vyučující
doc. RNDr. Jiří Dostál, CSc. (cvičící)
prof. RNDr. Eva Táborská, CSc. (cvičící)
doc. RNDr. Josef Tomandl, Ph.D. (cvičící)
Mgr. Jana Gregorová, Ph.D. (pomocník)
MUDr. Michaela Králíková, Ph.D. (pomocník)
RNDr. Hana Paulová, CSc. (pomocník)
doc. Mgr. Ondřej Peš, Ph.D. (pomocník)
Mgr. Jiří Slanina, Ph.D. (pomocník)
Mgr. Marie Tomandlová, Ph.D. (pomocník)
Garance
doc. RNDr. Josef Tomandl, Ph.D.
Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Kontaktní osoba: MUDr. Michaela Králíková, Ph.D.
Dodavatelské pracoviště: Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Předpoklady
aVLBC0321s Biochemistry I - seminar && aVLFY0321c Fyziologie I - cv. && aVLFY0321s Fyziologie I - sem.
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
Seminars are complementary to the course Biochemistry II - lecture. The aim of the course is to practise (i) the basic principles of intermediary metabolism and its regulation in various states of the organism at all levels, (ii) the characteristic features of metabolism of individual organs and tissues, (iii) the principles of maintaining homeostasis of the organism, including acid-base balance.
Výstupy z učení
The student will be able:
- to explain the interrelationship between the metabolism of nutrients under different states of the organism.
- to describe the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases.
- to understand and discuss principles of maintaining homeostasis and acid-base balance in the organism, including modelling situations
- to discuss the composition of body fluids and their disorders in connection with the principles of homeostasis.
- to explain the principles of metabolism regulation at all levels.
Osnova
  • Enzyme assays in clinical diagnostics. Methods in clinical biochemistry. Analysers, POCT.
  • Blood glucose. Protein metabolism. Proteins in nutrition. Transport forms of ammonia.
  • Lipoproteins and their metabolism. Cholesterol transport and balance.
  • Relationships between major metabolic pathways of essential nutrients in various states. Malnutrition. Obesity. Metabolic syndrome. Metabolism during stress.
  • Liver functions, role in nutrient metabolism. Heme catabolism, hyperbilirubinemia. Role of liver in metabolism of hormones and vitamins. Metabolism of Fe.
  • Biotransformation of xenobiotics. Metabolism of ethanol.
  • Water and mineral metabolism. Sodium and water homeostasis, osmolality and volemia.
  • Acid-base balance, parameters, regulation, disorders. Buffer bases. Transport of O2 a CO2.
  • Major functions of kidneys. Glomerular filtration. Tubular resorption and secretion.
  • Neurotransmitters and hormone receptors. The most common signal pathways.
  • Steroid and thyroid hormones.
  • Biochemistry of muscle work. Effect of NO. Energetics of muscle work.
  • Metabolism of Ca, Mg, P, F, I.
  • Extracellular matrix. Metabolism of connective tissue and skin, bone biomarkers.
Literatura
    povinná literatura
  • Study materials for the course in IS MU.
  • RODWELL, Victor W., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY a P. Anthony WEIL. Harper's illustrated biochemistry. Thirty-first edition. New York: McGraw-Hill, 2018, x, 789. ISBN 9781260288421. info
    doporučená literatura
  • LIEBERMAN, Michael, Allan D. MARKS a Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013, ix, 1014. ISBN 9781451100037. info
  • Recommended literature from medical physiology in the course aVLFY0422p.
Výukové metody
Seminary course. Class discussions on assigned topics.
Metody hodnocení
Credit. Conditions for giving the course-unit credit:
1) completion of all seminars and 2) completion of in-term tests.
Failure to meet the requirements of in-term tests requires a resit test, which may be repeated only once.
Detailed conditions are published in Study materials posted under the course/Interactive Syllabus.
Vyučovací jazyk
Angličtina
Informace učitele
Information about seminars, the conditions for giving the course-unit credit, and the syllabus are available in the IS MU in the course-related instructions.
Consultations are possible after a personal arrangement with the teacher.
Další komentáře
Předmět je vyučován každoročně.
Výuka probíhá každý týden.
Successful completion of the course is a condition for access to the exam in the course aVLBC0422p.
Nachází se v prerekvizitách jiných předmětů
Předmět je zařazen také v obdobích jaro 2017, jaro 2018, jaro 2019, jaro 2020, jaro 2021, jaro 2022, jaro 2023, jaro 2024.