aVLBC0422s Biochemie II - seminář

Lékařská fakulta
jaro 2022
Rozsah
0/3/0. 45. 3 kr. Ukončení: z.
Vyučující
doc. RNDr. Jiří Dostál, CSc. (cvičící)
prof. RNDr. Eva Táborská, CSc. (cvičící)
doc. RNDr. Josef Tomandl, Ph.D. (cvičící)
MUDr. Michaela Králíková, Ph.D. (pomocník)
RNDr. Hana Paulová, CSc. (pomocník)
Mgr. Jiří Slanina, Ph.D. (pomocník)
Bc. Ivana Ševčíková (pomocník)
Mgr. Marie Tomandlová, Ph.D. (pomocník)
Garance
doc. RNDr. Josef Tomandl, Ph.D.
Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Kontaktní osoba: prof. RNDr. Eva Táborská, CSc.
Dodavatelské pracoviště: Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Rozvrh seminárních/paralelních skupin
aVLBC0422s/28: St 11:00–13:30 A16/215, J. Tomandl
aVLBC0422s/29: St 11:00–13:30 A16/215, J. Tomandl
aVLBC0422s/30: St 11:00–13:30 A16/213, E. Táborská
aVLBC0422s/31: St 11:00–13:30 A16/213, E. Táborská
aVLBC0422s/32: Čt 12:00–14:30 A16/215, J. Tomandl
aVLBC0422s/33: Čt 12:00–14:30 A16/215, J. Tomandl
aVLBC0422s/34: Po 11:00–13:30 A16/213, J. Dostál
aVLBC0422s/35: Po 11:00–13:30 A16/213, J. Dostál
aVLBC0422s/36: St 16:00–18:30 A16/213, E. Táborská
aVLBC0422s/37: St 16:00–18:30 A16/213, E. Táborská
aVLBC0422s/38: Út 14:00–16:30 A16/213, J. Tomandl
aVLBC0422s/39: Út 14:00–16:30 A16/213, J. Tomandl
Předpoklady
aVLBC0321s Biochemistry I - seminar && aVLFY0321c Fyziologie I - cv. && aVLFY0321s Fyziologie I - sem.
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
Seminars are complementary to Biochemistry II lecture (VLBC0422p). At the end of the course, students understand the principles of intermediary metabolism, characteristic features of metabolism of individual organs and tissues and metabolism at various conditions of organism (well-fed state, fasting, starvation, metabolic stress, obesity, metabolic syndrome).
Výstupy z učení
The student is able:
- to explain the interrelationship between the metabolism of nutrients under different states of the organism.
- to describe the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases.
- to understand and discuss principles of maintaining homeostasis and acid-base balance in the organism, including modelling situations
- to discuss the composition of body fluids and their disorders in connection with the principles of homeostasis.
- to explain the principles of metabolism regulation at all levels.
Osnova
  • Enzyme assays in clinical diagnostics. Methods in clinical biochemistry (photometry, electrophoretic methods).
  • Blood glucose (sources, consumption, regulation). Diabetes mellitus. Proteins in nutrition. Absorption of amino acids, utilization of amino acids in tissues, blood transport of ammonia, the glutamine cycle. Hormonal regulation.
  • Plasma lipoproteins, interconversions of lipoproteins. Cholesterol transport, balance of cholesterol intake and excretion.
  • Integration of metabolism of nutrients: relationships among the major metabolic pathways in the fed state, post-absorptive state, prolonged starvation, obesity.
  • The liver functions – the role in metabolism of nutrients. Catabolism of haemoglobin, urobilinoids, the types of hyperbilirubinemia.
  • The liver functions – the role in metabolism of hormones, and vitamins. Metabolism of Fe. Biotransformation of xenobiotics. Metabolism of ethanol.
  • Water and mineral metabolism. Sodium and water homeostasis, osmolality and volume of water, regulation, disorders.
  • Blood acid-base parameters. Transport of O2 a CO2. Metabolic processes producing and consuming H+. Buffer bases. Acid base disorders.
  • Major functions of the kidney. Glomerular filtration. Tubular resorption and secretion.
  • Neurotransmitters and hormone receptors. The most common signal pathways.
  • Biochemistry of muscle work (skeletal, cardiac, smooth). Effect of NO. Energetics of muscle work.
  • Steroidal, thyroidal hormones – synthesis, secretion, effects
  • Metabolism of Ca, Mg, P, F, I. Hormones important for their metabolism.
  • Metabolism of connective tissue. Extracellular matrix. Mineralisation of bone tissue, regulation. Biochemical markers of bone metabolism. Cartilage and skin.
Literatura
    povinná literatura
  • Seminar texts available in IS MUNI.
  • RODWELL, Victor W., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY a P. Anthony WEIL. Harper's illustrated biochemistry. Thirty-first edition. New York: McGraw-Hill, 2018, x, 789. ISBN 9781260288421. info
    doporučená literatura
  • LIEBERMAN, Michael, Allan D. MARKS a Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013, ix, 1014. ISBN 9781451100037. info
Výukové metody
Seminary course. Class discussions on assigned topics.
Metody hodnocení
Course-unit credit.
Conditions for giving the course-unit credit (all conditions should be met):
  • completion of all lessons,
  • minimal success rate of 70 % from all revision tests or minimal success rate of 50 % from the credit test. The resit credit test can be taken only once.
    The detailed conditions are posted in IS MUNI (Study materials – Course-related instructions).
    • Vyučovací jazyk
    Angličtina
    Informace učitele
    https://is.muni.cz/auth/el/1411/jaro2022/aVLBC0422s/
    Information to seminars, the conditions for giving the course-unit credit and the syllabus are available in the IS MUNI in the Course-related instructions. The syllabus is also posted on the notice board of the Department of Biochemistry.
    Consultations are possible after a personal arrangement with the teacher.
    Další komentáře
    Předmět je vyučován každoročně.
    Successful completion of the course is a condition for access to the exam in the course aVLBC0422p.
    Nachází se v prerekvizitách jiných předmětů
    Předmět je zařazen také v obdobích jaro 2017, jaro 2018, jaro 2019, jaro 2020, jaro 2021, jaro 2023, jaro 2024, jaro 2025.