aVLBC0422s Biochemistry II - seminar

Faculty of Medicine
spring 2022
Extent and Intensity
0/3/0. 3 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (seminar tutor)
prof. RNDr. Eva Táborská, CSc. (seminar tutor)
doc. RNDr. Josef Tomandl, Ph.D. (seminar tutor)
MUDr. Michaela Králíková, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
Bc. Ivana Ševčíková (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: prof. RNDr. Eva Táborská, CSc.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable of Seminar Groups
aVLBC0422s/28: Wed 11:00–13:30 A16/215, J. Tomandl
aVLBC0422s/29: Wed 11:00–13:30 A16/215, J. Tomandl
aVLBC0422s/30: Wed 11:00–13:30 A16/213, E. Táborská
aVLBC0422s/31: Wed 11:00–13:30 A16/213, E. Táborská
aVLBC0422s/32: Thu 12:00–14:30 A16/215, J. Tomandl
aVLBC0422s/33: Thu 12:00–14:30 A16/215, J. Tomandl
aVLBC0422s/34: Mon 11:00–13:30 A16/213, J. Dostál
aVLBC0422s/35: Mon 11:00–13:30 A16/213, J. Dostál
aVLBC0422s/36: Wed 16:00–18:30 A16/213, E. Táborská
aVLBC0422s/37: Wed 16:00–18:30 A16/213, E. Táborská
aVLBC0422s/38: Tue 14:00–16:30 A16/213, J. Tomandl
aVLBC0422s/39: Tue 14:00–16:30 A16/213, J. Tomandl
Prerequisites (in Czech)
aVLBC0321s Biochemistry I - seminar && aVLFY0321c Physiology I - practice && aVLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Seminars are complementary to Biochemistry II lecture (VLBC0422p). At the end of the course, students understand the principles of intermediary metabolism, characteristic features of metabolism of individual organs and tissues and metabolism at various conditions of organism (well-fed state, fasting, starvation, metabolic stress, obesity, metabolic syndrome).
Learning outcomes
The student is able:
- to explain the interrelationship between the metabolism of nutrients under different states of the organism.
- to describe the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases.
- to understand and discuss principles of maintaining homeostasis and acid-base balance in the organism, including modelling situations
- to discuss the composition of body fluids and their disorders in connection with the principles of homeostasis.
- to explain the principles of metabolism regulation at all levels.
Syllabus
  • Enzyme assays in clinical diagnostics. Methods in clinical biochemistry (photometry, electrophoretic methods).
  • Blood glucose (sources, consumption, regulation). Diabetes mellitus. Proteins in nutrition. Absorption of amino acids, utilization of amino acids in tissues, blood transport of ammonia, the glutamine cycle. Hormonal regulation.
  • Plasma lipoproteins, interconversions of lipoproteins. Cholesterol transport, balance of cholesterol intake and excretion.
  • Integration of metabolism of nutrients: relationships among the major metabolic pathways in the fed state, post-absorptive state, prolonged starvation, obesity.
  • The liver functions – the role in metabolism of nutrients. Catabolism of haemoglobin, urobilinoids, the types of hyperbilirubinemia.
  • The liver functions – the role in metabolism of hormones, and vitamins. Metabolism of Fe. Biotransformation of xenobiotics. Metabolism of ethanol.
  • Water and mineral metabolism. Sodium and water homeostasis, osmolality and volume of water, regulation, disorders.
  • Blood acid-base parameters. Transport of O2 a CO2. Metabolic processes producing and consuming H+. Buffer bases. Acid base disorders.
  • Major functions of the kidney. Glomerular filtration. Tubular resorption and secretion.
  • Neurotransmitters and hormone receptors. The most common signal pathways.
  • Biochemistry of muscle work (skeletal, cardiac, smooth). Effect of NO. Energetics of muscle work.
  • Steroidal, thyroidal hormones – synthesis, secretion, effects
  • Metabolism of Ca, Mg, P, F, I. Hormones important for their metabolism.
  • Metabolism of connective tissue. Extracellular matrix. Mineralisation of bone tissue, regulation. Biochemical markers of bone metabolism. Cartilage and skin.
Literature
    required literature
  • Seminar texts available in IS MUNI.
  • RODWELL, Victor W., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY and P. Anthony WEIL. Harper's illustrated biochemistry. Thirty-first edition. New York: McGraw-Hill, 2018, x, 789. ISBN 9781260288421. info
    recommended literature
  • LIEBERMAN, Michael, Allan D. MARKS and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013, ix, 1014. ISBN 9781451100037. info
Teaching methods
Seminary course. Class discussions on assigned topics.
Assessment methods
Course-unit credit.
Conditions for giving the course-unit credit (all conditions should be met):
  • completion of all lessons,
  • minimal success rate of 70 % from all revision tests or minimal success rate of 50 % from the credit test. The resit credit test can be taken only once.
    The detailed conditions are posted in IS MUNI (Study materials – Course-related instructions).
    • Language of instruction
    English
    Further comments (probably available only in Czech)
    The course is taught annually.
    General note: Successful completion of the course is a condition for access to the exam in the course aVLBC0422p.
    Information on the extent and intensity of the course: 45.
    Listed among pre-requisites of other courses
    Teacher's information
    https://is.muni.cz/auth/el/1411/jaro2022/aVLBC0422s/
    Information to seminars, the conditions for giving the course-unit credit and the syllabus are available in the IS MUNI in the Course-related instructions. The syllabus is also posted on the notice board of the Department of Biochemistry.
    Consultations are possible after a personal arrangement with the teacher.
    Successful completion of the course is a condition for access to the exam in the course aVLBC0422p.
    The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2023, spring 2024, spring 2025.
    • Enrolment Statistics (spring 2022, recent)
    • Permalink: https://is.muni.cz/course/med/spring2022/aVLBC0422s