aVLBC0422s Biochemistry II - seminar

Faculty of Medicine
spring 2021
Extent and Intensity
0/3/0. 2 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (seminar tutor)
MUDr. Michaela Králíková, Ph.D. (seminar tutor)
RNDr. Hana Paulová, CSc. (seminar tutor)
Mgr. Jiří Slanina, Ph.D. (seminar tutor)
prof. RNDr. Eva Táborská, CSc. (seminar tutor)
doc. RNDr. Josef Tomandl, Ph.D. (seminar tutor)
Mgr. Marie Tomandlová, Ph.D. (seminar tutor)
MUDr. Miroslava Hlaváčová, Ph.D. (assistant)
Guaranteed by
prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable of Seminar Groups
aVLBC0422s/30: Thu 15:00–17:30 A16/215, J. Tomandl
aVLBC0422s/31: Thu 15:00–17:30 A16/215, J. Tomandl
aVLBC0422s/32: Thu 12:00–14:30 A16/213, E. Táborská, J. Tomandl
aVLBC0422s/33: Thu 12:00–14:30 A16/213, E. Táborská, J. Tomandl
aVLBC0422s/34: Mon 8:00–10:30 A16/215, E. Táborská, J. Tomandl
aVLBC0422s/35: Mon 8:00–10:30 A16/215, E. Táborská, J. Tomandl
aVLBC0422s/36: Tue 11:00–13:30 A16/215, E. Táborská, J. Tomandl
aVLBC0422s/37: Tue 11:00–13:30 A16/215, E. Táborská, J. Tomandl
aVLBC0422s/38: Thu 12:00–14:30 A16/215, J. Dostál
aVLBC0422s/39: Thu 12:00–14:30 A16/215, J. Dostál
Prerequisites (in Czech)
aVLBI0222p Medical Biology II - lect. && aVLBF011p Biophysics -lect. && aVLBC0321s Biochemistry I - sem. && aVLBC0321c Biochemistry I - pract. && aVLFY0321c Physiology I - practice && aVLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Seminars are complementary to Biochemistry II lecture (aVLBC0422p). At the end of the course students undestand principles of intermediary metabolism, characteristic features of metabolism of individual organs and tissues and metabolism at various conditions of organism (well fed state, fasting, starvation, metabolic stress, obesity, metabolic syndrome).
Learning outcomes
The student is able:
- to explain the interrelationship between the metabolism of nutrients under different states of the organism.
- to describe the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases.
- to understand and discuss principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations
- to discuss the composition of body fluids and their disorders in connection with the principles of homeostasis.
- to explain the principles of metabolism regulation at all levels.
Syllabus
  • Enzyme assays in clinical diagnostics. Methods in clinical biochemistry (photometry, electrophoretic methods). • Plasma lipoproteins, interconversions of lipoproteins. Cholesterol transport, balance of cholesterol intake and excretion. • Blood glucose (sources, consumption, regulation). Diabetes mellitus. • Proteins in nutrition. Absorption of amino acids, utilization of amino acids in tissues, blood transport of ammonia, the glutamine cycle. Hormonal regulation. • Integration of metabolism of nutrients: relationships among the major metabolic pathways in the fed state, post-absorptive state, prolonged starvation, obesity. • The liver functions – the role in metabolism of nutrients. Catabolism of haemoglobin, urobilinoids, the types of hyperbilirubinemia. • The liver functions – the role in metabolism of hormones, and vitamins. Metabolism of Fe. Biotransformation of xenobiotics. Metabolism of ethanol. • Water and mineral metabolism. Sodium and water homeostasis, osmolality and volume of water, regulation, disorders. Blood acid-base parameters. Transport of O2 a CO2. Metabolic processes producing and consuming H+. Buffer bases. Acid base disorders. • Major functions of the kidney. Glomerular filtration. • Tubular resorption and secretion. • Neurotransmitters and hormone receptors. The most common signal pathways. • Metabolism of Ca, Mg, P, F, I. Hormones important for their metabolism. • Metabolism of connective tissue. Extracellular matrix. Mineralisation of bone tissue, regulation. Biochemical markers of bone metabolism. Cartilage and skin. • Biochemistry of muscle work (skeletal, cardiac, smooth). Effect of NO.Energetics of muscle work.
Literature
    required literature
  • Seminar texts available in Information system
Teaching methods
Course is based on group discusion to the given topics. The outlines of discusion are in the recommended textbook. Complementary materials are available in section Study materials.
Assessment methods
Conditions of giving the credits • Submission of all completed protocols with answers to the Homework Vaults in relevant dates. • Required attendance in seminars. • All absences must be made up according to teacher instructions. • Obtaining 52 points or more from continuous revision tests or • Obtaining 14 points from the credit test
Language of instruction
English
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 45.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2022, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (spring 2021, recent)
  • Permalink: https://is.muni.cz/course/med/spring2021/aVLBC0422s