aVLBC0422s Biochemistry II - seminar

Faculty of Medicine
spring 2023
Extent and Intensity
0/3/0. 3 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. RNDr. Jiří Dostál, CSc. (seminar tutor)
RNDr. Hana Paulová, CSc. (seminar tutor)
prof. RNDr. Eva Táborská, CSc. (seminar tutor)
doc. RNDr. Josef Tomandl, Ph.D. (seminar tutor)
Mgr. Jana Gregorová, Ph.D. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
doc. Mgr. Ondřej Peš, Ph.D. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Bc. Ivana Ševčíková (assistant)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: RNDr. Hana Paulová, CSc.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable of Seminar Groups
aVLBC0422s/30: Mon 13. 2. to Thu 4. 5. Thu 12:00–14:30 A16/215; and Thu 18. 5. 12:00–14:30 A16/215, Thu 25. 5. 12:00–14:30 A16/215, J. Tomandl
aVLBC0422s/31: Wed 11:00–13:30 A16/215, J. Dostál
aVLBC0422s/32: Wed 11:00–13:30 A16/213, E. Táborská
aVLBC0422s/33: Wed 11:00–13:30 A16/213, E. Táborská
aVLBC0422s/34: Mon 8:00–10:30 A16/213, E. Táborská
aVLBC0422s/35: Mon 13. 2. to Thu 4. 5. Thu 12:00–14:30 A16/215; and Thu 18. 5. 12:00–14:30 A16/215, Thu 25. 5. 12:00–14:30 A16/215, J. Tomandl
aVLBC0422s/36: Wed 11:00–13:30 A16/215, J. Dostál
aVLBC0422s/37: Mon 13. 2. to Thu 4. 5. Thu 15:00–17:30 A16/215; and Thu 18. 5. 15:00–17:30 A16/215, Thu 25. 5. 15:00–17:30 A16/215, J. Tomandl
aVLBC0422s/38: Mon 8:00–10:30 A16/213, E. Táborská
aVLBC0422s/39: Mon 13. 2. to Thu 4. 5. Thu 15:00–17:30 A16/215; and Thu 18. 5. 15:00–17:30 A16/215, Thu 25. 5. 15:00–17:30 A16/215, J. Tomandl
Prerequisites (in Czech)
aVLBC0321s Biochemistry I - seminar && aVLFY0321c Physiology I - practice && aVLFY0321s Physiology I - seminar
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Seminars are complementary to the course Biochemistry II - lecture. The aim of the course is to practise (i) the basic principles of intermediary metabolism and its regulation in various states of the organism at all levels, (ii) the characteristic features of metabolism of individual organs and tissues, (iii) the principles of maintaining homeostasis of the organism, including acid-base balance.
Learning outcomes
The student will be able:
- to explain the interrelationship between the metabolism of nutrients under different states of the organism.
- to describe the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases.
- to understand and discuss principles of maintaining homeostasis and acid-base balance in the organism, including modelling situations
- to discuss the composition of body fluids and their disorders in connection with the principles of homeostasis.
- to explain the principles of metabolism regulation at all levels.
Syllabus
  • Enzyme assays in clinical diagnostics. Methods in clinical biochemistry. Analysers, POCT.
  • Blood glucose. Protein metabolism. Proteins in nutrition. Transport forms of ammonia.
  • Lipoproteins and their metabolism. Cholesterol transport and balance.
  • Relationships between major metabolic pathways of essential nutrients in various states. Malnutrition. Obesity. Metabolic syndrome. Metabolism during stress.
  • Liver functions, role in nutrient metabolism. Heme catabolism, hyperbilirubinemia. Role of liver in metabolism of hormones and vitamins. Metabolism of Fe.
  • Biotransformation of xenobiotics. Metabolism of ethanol.
  • Water and mineral metabolism. Sodium and water homeostasis, osmolality and volemia.
  • Acid-base balance, parameters, regulation, disorders. Buffer bases. Transport of O2 a CO2.
  • Major functions of kidneys. Glomerular filtration. Tubular resorption and secretion.
  • Neurotransmitters and hormone receptors. The most common signal pathways.
  • Steroid and thyroid hormones.
  • Biochemistry of muscle work. Effect of NO. Energetics of muscle work.
  • Metabolism of Ca, Mg, P, F, I.
  • Extracellular matrix. Metabolism of connective tissue and skin, bone biomarkers.
Literature
    required literature
  • Study materials for the course Biochemistry II in IS MUNI.
  • RODWELL, Victor W., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY and P. Anthony WEIL. Harper's illustrated biochemistry. Thirty-first edition. New York: McGraw-Hill, 2018, x, 789. ISBN 9781260288421. info
    recommended literature
  • LIEBERMAN, Michael, Allan D. MARKS and Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013, ix, 1014. ISBN 9781451100037. info
  • Recommended literature from medical physiology in the course aVLFY0422p.
Teaching methods
Seminary course. Class discussions on assigned topics.
Assessment methods
Course-unit credit.
Conditions for giving the course-unit credit (all conditions should be met):
  • completion of all lessons, missed lessons must be made up,
  • minimal success rate of 70 % from the sum of all revision tests or minimal success rate of 50 % from the credit test. The resit credit test can be taken only once.
    The detailed conditions are posted in IS MUNI (Study materials – Course-related instructions).
    • Language of instruction
    English
    Further comments (probably available only in Czech)
    The course is taught annually.
    General note: Successful completion of the course is a condition for access to the exam in the course aVLBC0422p.
    Information on the extent and intensity of the course: 45.
    Listed among pre-requisites of other courses
    Teacher's information
    Information to seminars, the conditions for giving the course-unit credit and the syllabus are available in the IS MUNI in the Course-related instructions. The syllabus is also posted on the notice board of the Department of Biochemistry.
    Consultations are possible after a personal arrangement with the teacher.
    Successful completion of the course is a condition for access to the exam in the course aVLBC0422p.
    The course is also listed under the following terms Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2024, spring 2025.
    • Enrolment Statistics (spring 2023, recent)
    • Permalink: https://is.muni.cz/course/med/spring2023/aVLBC0422s