LF:aZLPA0521p Patologie I - přednáška - Informace o předmětu

aZLPA0521p Patologie I - přednáška

Rozsah

2/0/0. 30. 1 kr. Ukončení: z.

Vyučující

prof. MUDr. Markéta Hermanová, Ph.D. (přednášející)
MUDr. Víta Žampachová (přednášející)
MUDr. Iva Staniczková Zambo, Ph.D. (přednášející)
Markéta Grozertová (pomocník)
Linda Penčová (pomocník)

Garance

prof. MUDr. Markéta Hermanová, Ph.D.
I. ústav patologie – Společná pracoviště s Fakultní nemocnicí u sv. Anny v Brně – Lékařská fakulta
Dodavatelské pracoviště: I. ústav patologie – Společná pracoviště s Fakultní nemocnicí u sv. Anny v Brně – Lékařská fakulta

Rozvrh

Po 16:40–19:10 PatÚI N01008

Předpoklady

aZLFY0422c Fyziologie II - cvičení && aZLFY0422s Fyziologie II - seminář && ( aZLBC041c Biochemie II - cvičení || aZLBC0422c Biochemie II - cvičení ) && ( aZLBC041s Biochemie II seminář || aZLBC0422s Biochemie II seminář ) && ( aZLAN0222p Anatomie II - předn. || aZLAN0333p Anatomie III - předn. )&& aZLHE0322p Histol. a embryol.II - předn. && aZLLT0222s Zákl. lék. terminologie II -s
aZLFY0422c && aZLBC041c && aZLAN0333p && aZLHE0322p && (aZLLT0222s || ZLLT0222s) && aZLET021p && aZC041

Omezení zápisu do předmětu

Předmět je určen pouze studentům mateřských oborů.

Mateřské obory/plány

• Dentistry (program LF, M-DENT)
• Zubní lékařství (angl.) (program LF, M-ZL)

Cíle předmětu

The main aims of the course include:
understanding the basic pathologic processes (regressive and progressive changes, inflammation, pathologic immune reactions, oncogenesis, genetic background of disease)
knowledge of basic classifications of non-neoplastic and neoplastic disorders
application of this knowledge in individual organ systems with focus on morphological substrate od individual disorders from both microscopis and macroscopic point of view
introduction of the role of pathology in clinical practice, of methods of tissue processing, methods of molecular pathology; demonstration of pathological anatomical autopsies and thier evaluation.

Výstupy z učení

Completing the course, the student will be able:
- to understand basic pathologic processes (regressive and progressive changes, inflammation, pathologic immune reactions, oncogenesis, genetic background of disease)
- to know basic classifications of both nonneoplastic and neoplastic disorders
- to apply the knowledge of general pathology to individual organ systems: to know basic etiopathogenesis, both macroscopic and microscopic correlates, basic clinical symptoms and complications of diseases in individual organ systems
- to know the role of pathology in clinical practive and main methods of examination in pathology.

Osnova

• Introductory information. Basic nomenclature: autopsy, histological necroptic and bioptical examination, the importance of autopsies. Death and postmortal changes. Necrosis: types and appearance, causes and further evolution. Apoptosis, maceration.
• Atrophy, hypertrophy, hyperplasia, metaplasia.
• Inflammation (acute, chronic); gross and macroscopic appearance Phagocytosis, cells engaged in inflammation. Chemical mediators of inflammation.
• Inflammation: types and their characteristics (superficial, deep, serous, fibrinous...). Macroscopic & microscopic changes Fever, sepsis, pyemia Healing and reparation Specific inflammation (tuberculosis, lues, lepra, sarkoidosis); granulomatous inflam-mation.
• Immune system and its function Immune reactions, their classification and pathology. Autoimmune diseases. Rejection.
• Immunodeficiency diseases (inborn and acquired). HIV. Infections in immunocompromised patients Infectious diseases.
• Hemodynamic disorders od perfusion (central and peripheral). Shock, fluid loss and overload Local disorders of circulation (infarction, embolism, edema), DIC, eclampsy.
• General oncology; Benign and malignant tumors and their classification.Cancerogenesis. Epithelial tumors, choriocarcinoma, mesothelioma.
• Leukemia. Lymphomas (WHO classification)
• Mesenchymal tumors. Tumors of peripheral nervous system Pigmented skin lesions. Neuroectodermal tumors of CNS.
• Cardiovascular pathology: congenital heart disease, inflammatory heart disease, ischemic heart disease, cardiomyopathy.
• Cardiovascular pathology: blood vessels (degenerative changes, vasculitis), myocardial biopsy.
• The respiratory systém.
• Autopsy, biopsy. Tissue fixation, sampling and processing. Frozen sections.Light, fluorescent, electron microscopy. Cytology (smears, fine needle aspirations). Routine and special staining, histochemistry, immunohistochemistry Molecular biology techniques.

Literatura

povinná literatura
• KUMAR, Vinay, Abul K. ABBAS, Jon C. ASTER a Andrea T. DEYRUP. Robbins essential pathology. Philadelphia: Elsevier, 2021, viii, 340. ISBN 9780323640251. info

doporučená literatura
• Underwood's pathology : a clinical approach. Edited by Simon S. Cross. 6th ed. Edinburgh: Churchill Livingstone, 2013, xviii, 769. ISBN 9780702046735. info
• KUMAR, Vinay. Robbins and Cotran pathologic basis of disease. Illustrated by James A. Perkins. 8th ed. Philadelphia: Saunders, 2010, xiv, 1450. ISBN 9781416031215. info

Výukové metody

Pathology course consists of lectures and practical classes. Practical classes include two parts: histopathological practices (with demonstration of microscopic and macroscopic findings of bioptic and auroptic samples) and autoptical practices (with demonstration of pathological anatomical autopsies).

Metody hodnocení

The course of pathology is closed by oral exam covering three sets of topics: general pathology, systemic pathology and oncology. The list of these topics is available to the students in advance. Attendance is compulsory, knowledge of the students is periodically tested during the practical classes. Testing is oral or by written tests.

Vyučovací jazyk

Angličtina

Informace učitele

Podrobné informace o průběhu výuky jsou vyvěšeny na I. PAÚ.

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