aVLPF0622c Patologická fyziologie II - cvičení

Lékařská fakulta
jaro 2018
Rozsah
0/3/0. 3 kr. Ukončení: z.
Vyučující
MUDr. Vendula Bartáková, Ph.D. (cvičící)
prof. MUDr. Julie Dobrovolná, Ph.D. (cvičící)
MUDr. Kamil Ďuriš, Ph.D. (cvičící)
doc. MUDr. Jaromír Gumulec, Ph.D. (cvičící)
MUDr. Michal Jurajda, Ph.D. (cvičící)
Mgr. Andrea Knight, Ph.D. (cvičící)
MUDr. Jan Máchal, Ph.D. (cvičící)
prof. RNDr. Michal Masařík, Ph.D. (cvičící)
Mgr. Lukáš Pácal, Ph.D. (cvičící)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (cvičící)
doc. RNDr. Sabina Ševčíková, Ph.D. (cvičící)
prof. MUDr. Anna Vašků, CSc. (cvičící)
Věra Ježková (pomocník)
Garance
prof. MUDr. Anna Vašků, CSc.
Ústav patologické fyziologie – Teoretická pracoviště – Lékařská fakulta
Kontaktní osoba: prof. MUDr. Anna Vašků, CSc.
Dodavatelské pracoviště: Ústav patologické fyziologie – Teoretická pracoviště – Lékařská fakulta
Rozvrh seminárních/paralelních skupin
aVLPF0622c/30: St 13:30–16:00 A18/114
aVLPF0622c/31: Čt 13:30–16:00 A18/108
aVLPF0622c/32: Út 13:30–16:00 A18/108
aVLPF0622c/33: Čt 13:30–16:00 A18/114
aVLPF0622c/34: Po 10:20–12:50 A18/108
aVLPF0622c/35: Út 13:30–16:00 A18/114
aVLPF0622c/36: St 13:30–16:00 A18/108
Předpoklady
aVLPF0521c Patol. fyziologie I - cvičení
Fyziologie, biochemie
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The objective of the practical exercises and seminars from pathological physiology is to provide students basic idea about pathological states and experimental work. Students will also acquire practical skills necessary for their subsequent(future) study and work.
Výstupy z učení
Student will explain the pharmacological options affecting the secretion of gastric juice in the context of experimentally induced gastric ulcer in experimental animal model (inhibition of proton pump, H2 receptor blockade);
Student will explain the pharmacological options affecting the secretion of gastric juice in the context of experimentally induced gastric ulcer in experimental animal model (inhibition of proton pump, H2 receptor blockade);
Student demonstrates the principle of load test (oGTT) in an animal model of experimentally induced diabetes (alloxan);
Student shall identify clinically relevant parameters describe nutritional status (calorimetry, BMI, WHR index, the weight, the skin-fold thickness, bioimpedance, DEXA) ;
Student demonstrates the examination of the quality of the skin barrier, through the examination of resistance and conductivity of the skin or a chemical (Burckhardt´s) examination with regard to the composition of the skin barrier;
Student demonstrates onset of obstruction icterus induced by ligation of ductus choledochus. He understands etiopathogenesis of other types of icterus (hemolytic, hepatic) and diagnostics of them using heme metabolites in urine, blood and stool using mitochondrial/cytoplasmatic membranes liver enzymes;
Student describes etiopathogenesis of venous thrombosis using data from experimental animal model;
Student will explain the importance and principles of DNA d iagnostics to detect I/D polymorphism using PCR methodology ACE
Osnova
  • Exp. induced peptic ulcer in lab. animal, image analysis.
  • Obstructice jaundice preparation
  • Exp. induced jaundice in lab. animal
  • Patophysiology of GIT (tutorial)
  • Statistical evaluation of experiments (advanced methods), practical analysis of exp. data (using stat. software) Neuropathophysilogy (tutorial)
  • Exp. induced vein thrombosis in lab. animal
  • Overview of molecular biology exp. methods used in pathophysiology (tutorial & demonstration of selected lab. methods)
  • Genetic susceptibility to disease – monogenic vs. complex diseases (tutorial)
  • Haematology, blood transfusion (tutorial) Anaphylactic reaction, pathophysiology of circulatory shock (tutorial)
  • Skin barrier disorders (measurement of skin conductivity)
  • Exp. induced diabetes mellitus preparation
  • Exp. induced diabetes mellitus – diagnosis by glucose tolerance test
Literatura
Výukové metody
practical exercises in lab, seminars
Metody hodnocení
Practicals are compulsory (the only permited reason for not attending is a student's sick leave). Students can be given written tests or individual home work by tutor's throughout the term. Student's participation in the practicals throughout the term is certified by a credit given upon the following conditions: (i) complete attendance, (ii) complete protocols from the exp. practicals, (iii) indicidual criteria announced by the principal tutor.
Vyučovací jazyk
Angličtina
Informace učitele
http://www.med.muni.cz/patfyz/patfyzc.html
Students have to be wearing lab coats during the practicals and follow the safety rules when working experimentally. Student can - with tutor's approval - substitute the particular practical in a given week with another group in case he/she has a justifiable reason for it.
Další komentáře
Studijní materiály
Předmět je vyučován každoročně.
Nachází se v prerekvizitách jiných předmětů
Předmět je zařazen také v obdobích jaro 2019, jaro 2020, jaro 2021, jaro 2022, jaro 2023, jaro 2024, jaro 2025.