aZLBC041s Biochemie II - seminář

Lékařská fakulta
jaro 2018
Rozsah
0/2/0. 2 kr. Ukončení: z.
Vyučující
Ing. Martina Čarnecká, Ph.D. (cvičící)
doc. RNDr. Jiří Dostál, CSc. (cvičící)
Mgr. Jana Gregorová, Ph.D. (cvičící)
MUDr. Miroslava Hlaváčová, Ph.D. (cvičící)
MUDr. Michaela Králíková, Ph.D. (cvičící)
RNDr. Hana Paulová, CSc. (cvičící)
doc. Mgr. Ondřej Peš, Ph.D. (cvičící)
Mgr. Jiří Slanina, Ph.D. (cvičící)
prof. RNDr. Eva Táborská, CSc. (cvičící)
doc. RNDr. Josef Tomandl, Ph.D. (cvičící)
Mgr. Marie Tomandlová, Ph.D. (cvičící)
Lenka Nerudová (pomocník)
Mgr. Jindra Smutná, Ph.D. (pomocník)
Garance
prof. RNDr. Eva Táborská, CSc.
Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Dodavatelské pracoviště: Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Rozvrh
Čt 7:30–9:10 A16/213
Předpoklady
aZLLC011p Lékařská chemie - předn. && aZLBF011p Lékařská fyzika a infor.-lec. && aZLBI0222p Biologie II - přednáška && aZLBC0221s Biochemie I - seminář
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
Seminars are complementary to Biochemistry lecture (ZLBC041p). The knowledge of intermediary metabolism, characteristic features of metabolism of individual organs and tissues and metabolism at various conditions of organism (well fed state, fasting, starvation, metabolic stress, obesity, metabolic syndrome)are thoroughly practiced during Biochemistry seminars.
Výstupy z učení
The student is able to:
- explain the interrelationship between the metabolism of nutrients under different states of the organism.
- describe the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases.
- understand and discusse principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations
- discusse the composition of body fluids and their disorders in connection with the principles of homeostasis.
- explain the principles of metabolism regulation at all levels.
Osnova
  • Biochemical tests in clinical medicine and their significance. Biological material handling. Blood collection, plasma, serum. Laboratory tests in clinical biochemistry. Sources of error, assessing the significance of a test result. Enzyme assays in clinical diagnostics. Plasma lipoproteins, interconversion of lipoproteins. Cholesterol transport, balance of cholesterol intake and excretion. Blood glucose (sources, consumption, regulation). Diabetes mellitus. Catabolism of proteins and of amino acid nitrogen. Proteins in nutrition. Absorption of amino acids, utilization of amino acids in tissues, blood transport of fixed ammonia, the glutamine cycle. Nitrogenous compounds excreted into the urine. Protein intake and nitrogen balance. Integration of metabolism of nutrients: relationships among the major metabolic pathways in the fed state, postabsorptive state, and prolonged starvation. The liver functions – the role in metabolism of nutrients, hormones, and vitamins. Catabolism of haemoglobin, urobilinoids, the types of hyperbilirubinaemia. Biotransformation of xenobiotics. Neurotransmitter and hormone receptors. Water and mineral metabolism. Electrolyte composition of blood plasma, buffer bases. Respiration – transport of oxygen and CO2. The role of the kidney and the liver in acid-base balance. Blood acid-base parameters, the values indicating particular type of disturbance. Major functions of the kidney. Glomerular filtration. Tubular resorption and secretion. Metabolism of Ca, P and F. Composition and metabolism of bones and teeth. Saliva and biochemical aspects of oral homeostasis. Plaque formation and metabolism. Influence of nutrition on oral health.
Literatura
    povinná literatura
  • Podklady pro semináře jsou k dispozici v IS, studijní materiály předmětu ZLBC041s. Seminar files are available in IS, study materials of ZLBC041s.
Výukové metody
Course is based on group discusion to the given topics. The outlines of discusion are in the recommended textbook. Complementary materials are available in section Study materials.
Metody hodnocení
Conditions for giving the course-unit credit: Three short tests are written during the semester. Students that will obtain 42/60 points or more during the semester are not obliged to write the credit test. The other students will write the credit test with the 30 questions in the last week of the semester. The limit for passing the credit test is 14 points. Students that will not fulfill this limit will be allowed to repeat the test once. Remedial dates for writing the credit test will be scheduled in IS. Students that will not fulfill this requirement will not be given the course-unit credit. Obtaining of course-unit credits of practices and seminars is the pre-requisite for registration to the examination of Biochemistry II
Vyučovací jazyk
Angličtina
Další komentáře
Studijní materiály
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Předmět je zařazen také v obdobích jaro 2017, jaro 2019, jaro 2020.