LF:aZLFA0621p Pharmacology I - lect. - Course Information

aZLFA0621p Pharmacology I - lecture

Extent and Intensity

1/0/0. 0 credit(s). Type of Completion: z (credit).

Teacher(s)

doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
Mgr. Petra Amchová, Ph.D. (lecturer)
doc. RNDr. Ladislava Bartošová, Ph.D. (lecturer)
Mgr. Jana Kubátová, Ph.D. (lecturer)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (lecturer)
MUDr. Jana Nováková, Ph.D. (lecturer)
PharmDr. Adriána Papiež, Ph.D. (lecturer)
MUDr. Jana Pistovčáková, Ph.D. (lecturer)
doc. PharmDr. Jana Rudá, Ph.D. (lecturer)
PharmDr. Jitka Rychlíčková, Ph.D. (lecturer)
Mgr. Barbora Říhová, Ph.D. (lecturer)
PharmDr. Lenka Součková, Ph.D. (lecturer)
prof. MUDr. Dalibor Valík, Ph.D., DABCC (lecturer)
prof. RNDr. Lenka Zdražilová Dubská, Ph.D. (lecturer)
doc. PharmDr. Ondřej Zendulka, Ph.D. (lecturer)
Renata Bláblová (assistant)
Květoslava Sedlářová (assistant)
Mgr. Martin Brož (alternate examiner)
Mgr. Kateřina Nebeská (alternate examiner)
Mgr. Kristýna Nosková, Ph.D. (alternate examiner)

Guaranteed by

doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. MUDr. Regina Demlová, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine

Prerequisites (in Czech)

aZLPA0521c Pathology I - practice && aZLPF0521c Pathophysiol.I - practice && aZLCP051c Clin. Introd. in Surgery-prac.

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

• Dentistry (eng.) (programme LF, M-ZL)
• Dentistry (programme LF, M-ZL)

Course objectives

At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.

Learning outcomes

At the end of the course student will be able:
- to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics).
- be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.

Syllabus

• LECTURES

• Spring semester 2020

• 1^st week
• Historical aspects of pharmacology. Pharmacology — definitions, terminology, subspecializations. The active substance, pharmacon - drug. Effective pharmacotherapy.
• 2^nd week
• Mechanisms of drug action, non-specific, specific. Receptor and binding sites subtypes, autoreceptors, heteroreceptors, their function.
• 3^rd week
• Basic principles of Pharmacokinetics. Drug absorption, distribution, metabolism and elimination. Changes of drug effects after the repeated administration.
• 4^th week
• Adverse drug effects. Physiological and pathological factors influencing drug effects. Influence of concomitant diseases on drug effect, polypragmasia.
• 5^th week
• Specificities of pharmacotherapy in pediatric population and in elderly.
• 6^th week
• General principles of poisoning management. Specific antidotes in poisoning therapy.
• 7^th week
• Types of addiction, therapy of substance abuse.
• 8^th week
• Drug interactions at different levels. Assessment of their seriousness.

Literature

required literature
• RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info
• http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live

recommended literature
• http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
• WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info

not specified
• Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
• Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
• Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8

Teaching methods

According to schedule given students are expected to attend lectures read by habilitated pharmacology teacher.

Assessment methods

There is no testing of knowledge in this part of study as students are expected to continue pharmacological course in the subsequent semester.

Language of instruction

English

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
The course is taught every week.
Information on the extent and intensity of the course: 30.

• Enrolment Statistics (spring 2020, recent)
  
• Permalink: https://is.muni.cz/course/med/spring2020/aZLFA0621p