aZLFA0621p Pharmacology I - lecture

Faculty of Medicine
spring 2025
Extent and Intensity
1/0/0. 1 credit(s). Type of Completion: z (credit).
In-person direct teaching
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (lecturer)
doc. PharmDr. Jan Juřica, Ph.D. (lecturer)
Mgr. Petra Amchová, Ph.D. (lecturer)
doc. RNDr. Ladislava Bartošová, Ph.D. (lecturer)
Mgr. Jana Kubátová, Ph.D. (lecturer)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (lecturer)
MUDr. Jana Pistovčáková, Ph.D. (lecturer)
doc. PharmDr. Jana Rudá, Ph.D. (lecturer)
PharmDr. Jitka Rychlíčková, Ph.D. (lecturer)
Mgr. Barbora Říhová, Ph.D. (lecturer)
PharmDr. Lenka Součková, Ph.D. (lecturer)
Mgr. Kristýna Nosková, Ph.D. (alternate examiner)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. Mgr. MVDr. Leoš Landa, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Timetable
Thu 27. 2. 13:00–14:40 C15/332, Thu 6. 3. 13:00–14:40 C15/332, Thu 13. 3. 13:00–14:40 C15/332, Thu 20. 3. 13:00–14:40 C15/332, Thu 27. 3. 13:00–14:40 C15/332, Thu 3. 4. 13:00–14:40 C15/332, Thu 10. 4. 13:00–14:40 C15/332, Thu 17. 4. 13:00–14:40 C15/332
Prerequisites (in Czech)
aZLPA0521c Pathology I - practice && aZLPF0521c Pathophysiol. I - practice && aZLCP051c Clin. Introd. in Surgery-prac.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
At the end of the course, the student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of drugs effects and under which conditions they may elicit therapeutic, adverse, and toxic effects in selected indications.
Learning outcomes
At the end of the course student will be able:
to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of drugs effects and under which conditions they may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given and route of administration.
To undertstand the principles of use of drugs for treatment of GIT disorders and diabetes.
To understand indications for drugs affecting ANS, pharmacollogically used hormones and principles of biological therapy.
Syllabus

  • LECTURES

  • Spring semester 2025

  • 1st week
  • INTRODUCTION TO THE STUDY OF PHARMACOLOGY, LIFE CYCLE OF DRUGS
  • Definitions and basic terminology in pharmacology, subbranches. Classification and names of drugs. Types of pharmacotherapy, rational pharmacotherapy, legislation and regulation related to medicines. Safety of medicines, types of doses. Life cycle of medicines.
  • 2nd week
  • BASIC PHARMACOKINETICS AND PHARMACODYNAMICS
  • General principles of drug movement in the organism. Absorption, distribution, biotransformation, excretion. Basic pharmacokinetic parameters. Specific and non-specific mechanisms of drug action. Receptor theory.
  • 3rd week
  • DRUG SAFETY, FACTORS INFLUENCING DRUG ACTION
  • Classification and characteristics of adverse drug reactions. Pharmacovigilance in clinical practice, sources of current information on drug safety. Classification, overview and examples of factors influencing drug action. Basics of pharmacogenetics. Classification of drug interactions. Pharmacotherapy in childhood, pregnancy, lactation, old age
  • 4th week
  • ANTIDIABETICS, INSULINS
  • Classification, therapeutic use and basic pharmacological characteristics
  • 5th week
  • PHARMACOLOGICALLY USED HORMONES
  • Estrogens, antiestrogens, gestagens, antigestagens, androgens, antiandrogens - basic pharmacological characteristics. Hormonal contraceptives. Drugs used in the therapy of thyroid diseases and affecting bone metabolism. Overview of glucocorticoids and their therapeutic use.
  • 6th week
  • INTRODUCTION TO THE PHARMACOLOGY OF ANS
  • Introduction to the pharmacology of sympathetic and parasympathetic nervous systems - neurotransmission, receptors. Overview and basic pharmacological characteristics of drugs affecting sympathetic and parasympathetic activity.
  • 7th week
  • PHARMACOLOGY OF THE GASTROINTESTINAL TRACT, PHARMACOLOGY OF HISTAMINE
  • Classification and overview of H1-antihistamines.
  • 8th week
  • BASICS OF BIOLOGICAL THERAPY Principles of biological therapy, examples of drugs and their use, pharmacokinetics of monoclonal antibodies, specific side effects of biologics.
Literature
    required literature
  • RITTER, James, R. J. FLOWER, Graeme HENDERSON, Yoon Kong LOKE, David J. MACEWAN and H. P. RANG. Rang and Dale's pharmacology. Ninth edition. Edinburgh: Elsevier, 2020, xvi, 789. ISBN 9780702074486. info
  • Selected chapters from general pharmacology for students of general medicine and dentistry at FM MU, https://portal.med.muni.cz/discipline-13-pharmacology
    recommended literature
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info
    not specified
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
Teaching methods
Students are expected to follow the provided lectures.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 15.
Teacher's information
Information for the students:

Termination in the Spring semester: credit.

The course is also listed under the following terms Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024.
  • Enrolment Statistics (recent)
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