LF:VLFA0722p Pharmacology - L - Course Information

VLFA0722p Pharmacology - lectures

Faculty of Medicine
autumn 2018

Extent and Intensity

2/0/0. 5 credit(s). Type of Completion: zk (examination).

Teacher(s)

Guaranteed by

doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: Renata Bláblová
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine

Prerequisites (in Czech)

VLFA0621c Pharmacology I - p && ( VSAJ0222 English 1 II -p || VLAJ0222 English 1 II -p || VSCJ0686 Czech for Foreigners VI -p || VSNJ0222 German 1 II -p || VSSJ0222 Spanish 1 II -p )

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

General Medicine (eng.) (programme LF, M-VL)
General Medicine (programme LF, M-VL)

Course objectives

At the end of the course student will be oriented in drug classes according to their main therapeutic indications, in pharmacological profiles of therapeutic and adverse effects of particular drugs with an attention paid to common drug-drug interactions. The student will be able to judge pharmacoeconomic analyses for pharmacotherapy used in practice.

Learning outcomes

Syllabus

VLFA07212p - Pharmacology I - Lectures

General medicine

Autumn semester 2018
1^st week
Topic: PHARMACOLOGY AND ITS SUB-BRANCHES
Course content: Definition of pharmacology and its sub-branches of pharmacology. Drug, medical product – basic pharmacological terminology. Sources of research and development of new drugs. Principles of correct drug use – types of pharmacotherapy and rational pharmacotherapy.
2^nd week
Topic: OVERVIEW OF DRUG DOSAGE FORMS
Course content: Classification and overview of drug dosage forms for ready-made production and individual preparation, advantages and disadvantages of the particular types of drug dosage forms in clinical use, typical auxiliary substances (excipients). Drug dosage forms with controlled release.
3^rd week
Topic: ROUTES OF DRUG ADMINISTRATION
Course content: Classification of routes of administration, description of the individual ways with examples of drugs. Overview of innovative administration routes.
4^th week
Topic: PHARMACOKINETICS I
Course content: General principles of drug fate in the organism. Overview of the individual pharmacokinetic processes and parameters.
5^th week
Topic: PHARMACOKINETICS II
Course content: Single, continual and repeated drug administration. Principles of therapeutic drug monitoring. Compartment models. Fundamentals of population pharmacokinetics.
6^th week
Topic: PHARMACODYNAMICS
Course content: Mechanisms of drugs effects – classification, examples. Receptor theory – types of ligands and receptors. Change in drug effect after repeated administration.
7^th week
Topic: DRUG SAFETY
Course content: Adverse drug effects - classification and characteristics. Pharmacovigilance in clinical research and practice. Therapeutic index, therapeutic range. Drug anamnesis, polypharmacy and introduction to drug interactions.
8^th week
Topic: FACTORS AFFECTING DRUG EFFECTS
Course content: Classification, overview and examples of factors affecting drug effects. Fundamentals of pharmacogenetics.
9^th week
Topic: PHARMACOLOGY OF AUTONOMIC NERVOUS SYSTEM
Course content: Overview of pharmacology of sympathetic and parasympathetic nervous system – neurotransmission, receptors. Basic indications of substances affecting ANS.
10^th week
Topic: RESEARCH IN PHARMACOLOGY
Course content: Methods of experimental pharmacological research – brief overview. Examples from the Department of Pharmacology - Faculty of Medicine, MU.
11^th week
Topic: BASIC PRINCIPLES OF BIOLOGICAL THERAPY
Course content: Definition of terms, advantages and disadvantages of biological treatment in comparison to conventional therapy. Fundamental principles of technologies used in production of biological medical products, their classification and examples of clinical use.
12^th week
Topic: PHARMACOTHERAPY OF DIABETES MELLITUS
Course content: Insulins and anti-diabetic drugs – classification and basic pharmacological characteristics.
13^th week
Topic: PHARMACOLOGY OF SEX HORMONES
Course content: Analogues and antagonists FSH, LH. Oestrogens, antioestrogens, gestagens, antigestagens, androgens, antiandrogens basic pharmacological characteristics (classification, basic substances, therapeutic indications/contraindications, adverse effects).
14^th week
Topic: ANALGESIC DRUGS
Course content: Classification of analgesic drugs. Basic pharmacological characteristics and examples of use of opioid analgesics, non-steroidal anti-inflammatory drugs and analgesic-antipyretic drugs.
15^th week
Topic: GENERAL AND LOCAL ANAESTHETIC AGENTS
Course content: Classification and pharmacological characteristics of general and local anaesthetic drugs.
----------------------------------------------------------------------------------------------------------------------------------------
VLFA0722p - Pharmacology II - Lectures

General medicine

Autumn semester 2017
28.9.2017
Bank Holiday.
5.10.2017
Antihypertensives. Diuretics, antiadrenergics, vasodilators, combinative pharmacotherapy.
12.10.2017
Pharmacotherapy of heart failure. Inotropic drugs (digitalis, amrinone, dobutamine).
19.10.2017
Introduction to psychopharmacology. Neurotransmitter mechanisms and specific neurotransmitter systems. Antipsychotics.
26.10.2017
Anti-Parkinson pharmacotherapy. Drugs used in Alzheimer`s disease and other states of dementia. Anti-manic drugs.
2.11.2017
Drug addiction.
9.11.2017
Principles of biological therapy, monoclonal antibodies and therapeutic use.
16.11.2017
Principles of targeted therapy in oncology, monoclonal antibodies, tyrosinkinases inhibitors. Adverse drug reactions.
23.11.2017
Antimycotics, mechanism of action and adverse effects. Antivirotics.
30.11.2017
Basic principles of immunotherapy. Advanced therapy medicinal products.

Literature

required literature

RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info
http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html

recommended literature

LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén, 2007, xxiv, 672. ISBN 9788072623730. info
WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info

not specified

DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada, 2006, 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. info
http://portal.med.muni.cz/modules.php?name=News&file=article&sid=367
https://is.muni.cz/auth/el/1411/podzim2008/ZLFA0722p/um/Zasady_antibioticke_ lecby.pdf?fakulta=1411;obdobi=4343;kod=ZLFA0722p
Vybrané kapitoly z učebnice: http://books.google.cz/books?id=7lNQpLuETq4C&printsec=frontcover&dq=farmakologie&lr=&as_brr=3#PPA4,M1
Vybrané kapitoly z učebnice: http://books.google.cz/books?ct=result&q=farmakologie&lr=&as_brr=3&sa=N&start=0
ŠULCOVÁ, Alexandra. Poznámky k přednáškám z farmakologie. 1. vyd. Brno: Masarykova univerzita, 1993, 97 s. ISBN 80-210-0640-4. info
Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
Pharmaceutical Practice. Winfield, A.J. & Richards, R.M.E., eds. Churchill Livingstone. , 3rd Ed. 2004. ISBN 0443 07206 X
MARTÍNKOVÁ, Jiřina. Farmakologie pro studenty zdravotnických oborů. 2., zcela přeprac. a doplň. Praha: Grada, 2014. ISBN 9788024713564. info

Teaching methods

According to schedule given students are expected to attend lectures read by habilitated pharmacology teacher.

Assessment methods

The final exam is guided by the entrance test (ROPOT, the test contains 30 questions randomly generated for individual student (number of correct answers indicated)). In case of successful completion of the entrance test the exam continues by oral examination (three randomly selected questions corresponding with Syllabus (general pharmacological principles, drug classes, question of detailed knowledge about a selected drug).

Language of instruction

Czech

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

VLCH091 Surgery
(VLFA08222c || VLFA0722p) && VLCH0832c
VLCH9X33c Surgery III - practicals
(VLFA08222c || VLFA0722p) && VLCH0832c
VLNE9X1c Neurology - practice
(VLFA08222c || VLFA0722p) && (VLDI7X1c || VLDM7X1c) && VLOL7X1c && VLCH0832c
VLNE9X1p Neurology - lecture
(VLFA08222c || VLFA0722p) && (VLDI7X1c || VLDM7X1c) && VLOL7X1c && VLCH0832c
VLPD0932c Pediatrics II - practice
(VLFA08222c || VLFA0722p) && VLPD7X31c && VLOT7X1c && VLDI7X1c && VLKG7X1c
VLPD0932p Pediatrics II - lectures
(VLFA08222c || VLFA0722p) && VLPD7X31c && VLOT7X1c && VLDI7X1c && VLKG7X1c
VLVL9X62 Internal medicine part 2- Pneumology
(VLFA08222c || VLFA0722p)
VLVL9X63c Internal medicine part 3 - Nephrology, Diabetology, Rheumatology and Endocrinology
(VLFA08222c || VLFA0722p)
VLVL9X64c Internal medicine part 4 - Gastroenterology and Haematology
(VLFA08222c || VLFA0722p)

Zobrazit další předměty

The course is also listed under the following terms Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, Autumn 2017, autumn 2019.

Enrolment Statistics (autumn 2018, recent)
Permalink: https://is.muni.cz/course/med/autumn2018/VLFA0722p

LF:VLFA0722p Pharmacology - L - Course Information

VLFA0722p Pharmacology - lectures

Other applications