aZLBC0321s Biochemistry I - seminar

Lékařská fakulta
podzim 2021
Rozsah
0/2/0. 30. 3 kr. Ukončení: z.
Vyučující
MUDr. Michaela Králíková, Ph.D. (cvičící)
doc. RNDr. Josef Tomandl, Ph.D. (cvičící)
doc. RNDr. Jiří Dostál, CSc. (pomocník)
RNDr. Hana Paulová, CSc. (pomocník)
Mgr. Jiří Slanina, Ph.D. (pomocník)
Mgr. Jindra Smutná, Ph.D. (pomocník)
Bc. Ivana Ševčíková (pomocník)
prof. RNDr. Eva Táborská, CSc. (pomocník)
Mgr. Marie Tomandlová, Ph.D. (pomocník)
Garance
doc. RNDr. Josef Tomandl, Ph.D.
Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Kontaktní osoba: prof. RNDr. Eva Táborská, CSc.
Dodavatelské pracoviště: Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Rozvrh
Pá 12:00–13:40 A16/213
Předpoklady
aZLLC011p Med Chem, Dental Mat - lect && aZLBF011p Lékařská fyzika a infor.-lec. && aZLBI0222p Biologie II - přednáška
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
Seminars are complementary to Biochemistry I lecture (ZLBC0221p). At the end of the course student understand and can describe the major metabolic pathways and their significance.
Výstupy z učení
In the end of the course students will able to:
  • understand the properties and function of enzymes.
  • describe basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism.
  • understand the principles of energy production, utilization and deposition at the cellular level.
  • explain the function of cell membranes, the principle of compartmentalization at the cellular level, and the transport processes on the membrane.
  • describe protein synthesis, starting with the replication and transcription, translation and post-translational modifications.
  • understand the relationship between protein structure and function.
  • explain the function of hemoglobin in oxygen transport and maintaining acid-base balance.
  • discuss the principles of some diseases at the molecular level.
    • Osnova
    • Introduction into the metabolism of cells (differences between prokatyotic and eukaryotic cell).
    • Membrane structure and assembly. Transport across membranes.
    • Structure of haemoglobin and its relationship to the function. Hb types in the blood of healthy subjects, HbCO and MetHb, abnormal Hb types.
    • Enzymes - reaction rate, progress curve, the Michaelis plot and Michaelis constant, enzyme inhibition.
    • Coenzymes, their relationship to vitamins.
    • The citric acid cycle. The respiratory chain and oxidative phosphorylation.
    • Digestion of saccharides. Metabolism of glucose - glycolysis, gluconeogenesis. Glycogenesis and glycogenolysis.
    • Digestion of proteins. Metabolism of proteins. Common features of amino acid conversion. The synthesis of urea. Nitrogen balance.
    • Important reactions in amino acid catabolism. li>Digestion of lipids. Biosynthesis and desaturation of fatty acids. Ketogenesis. Synthesis of triacylglycerols.
    • Desaturation of fatty acids. Metabolism of phospholipids. Metabolism of cholesterol and bile acids.
    • Replication, transcription.
    Literatura
      povinná literatura
    • Seminar texts available in Information system
    • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017, viii, 567. ISBN 9781496363541. info
      doporučená literatura
    • KOOLMAN, Jan a Klaus-Heinrich RÖHM. Color atlas of biochemistry. 3rd ed., rev. and updated. Stuttgart: Thieme, 2013, ix, 495. ISBN 9783131003737. info
    • LIEBERMAN, Michael, Allan D. MARKS a Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013, ix, 1014. ISBN 9781451100037. info
    • VASUDEVAN, D. M., S. SREEKUMARI a Kannan VAIDYANATHAN. Textbook of biochemistry for dental students. 3rd edition. New Delhi: Jaypee, 2017, xiii, 289. ISBN 9789352701148. info
    Výukové metody
    Seminar. The course is based on group discussion on the given topics. The outlines of the discussion are in the recommended textbook. Complementary materials are available in section Study materials.
    Metody hodnocení
    Course-unit credit. Conditions for giving the course-unit credit (both conditions should be met):
  • Full attendance in lessons. All absences should be justified and then made up.
  • At least 70% success rate from partial revision tests or 50% success rate in credit test, the resit credit test can be taken only once.
    The detailed conditions are posted in Information System (Study materials – Course-related instructions).
    • Vyučovací jazyk
    Angličtina
    Další komentáře
    Předmět je vyučován každoročně.
    Nachází se v prerekvizitách jiných předmětů
    Předmět je zařazen také v obdobích podzim 2020, podzim 2022, podzim 2023, podzim 2024.