aZLBC0321s Biochemistry I - seminar

Lékařská fakulta
podzim 2023
Rozsah
0/2/0. 30. 3 kr. Ukončení: z.
Vyučující
RNDr. Hana Paulová, CSc. (cvičící)
Mgr. Jiří Slanina, Ph.D. (cvičící)
doc. RNDr. Josef Tomandl, Ph.D. (cvičící)
doc. RNDr. Jiří Dostál, CSc. (pomocník)
MUDr. Michaela Králíková, Ph.D. (pomocník)
Mgr. Jindra Smutná, Ph.D. (pomocník)
prof. RNDr. Eva Táborská, CSc. (pomocník)
Mgr. Marie Tomandlová, Ph.D. (pomocník)
Garance
doc. RNDr. Josef Tomandl, Ph.D.
Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Kontaktní osoba: MUDr. Michaela Králíková, Ph.D.
Dodavatelské pracoviště: Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Rozvrh
St 16:00–17:40 A16/215
Předpoklady
aZLLC011p Med Chem, Dental Mat - lect && aZLBF011p Lékařská fyzika a infor.-lec. && aZLBI0222p Biologie II - přednáška
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The aim of the course is to practice basic metabolic processes and pathways occurring at the cellular level.
Understanding these processes is the basis for understanding metabolism at the tissue and organ level, which is studied in the follow-up course Biochemistry II.
Výstupy z učení
In the end of the course students will able to:
  • understand the properties and function of enzymes.
  • describe basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism.
  • understand the principles of energy production, utilization and deposition at the cellular level.
  • explain the function of cell membranes, the principle of compartmentalization at the cellular level, and the transport processes on the membrane.
  • describe protein synthesis, starting with the replication and transcription, translation and post-translational modifications.
  • understand the relationship between protein structure and function.
  • explain the function of hemoglobin in oxygen transport and maintaining acid-base balance.
  • discuss the principles of some diseases at the molecular level.
    • Osnova
    • Introduction into the metabolism of cells (differences between prokatyotic and eukaryotic cell).
    • Membrane structure and assembly. Transport across membranes.
    • Structure of haemoglobin and its relationship to the function. Hb types in the blood of healthy subjects, HbCO and MetHb, abnormal Hb types.
    • Enzymes - reaction rate, progress curve, the Michaelis plot and Michaelis constant, enzyme inhibition.
    • Coenzymes, their relationship to vitamins.
    • The citric acid cycle. The respiratory chain and oxidative phosphorylation.
    • Digestion of saccharides. Metabolism of glucose - glycolysis, gluconeogenesis. Glycogenesis and glycogenolysis.
    • Digestion of proteins. Metabolism of proteins. Common features of amino acid conversion. The synthesis of urea. Nitrogen balance.
    • Important reactions in amino acid catabolism. li>Digestion of lipids. Biosynthesis and desaturation of fatty acids. Ketogenesis. Synthesis of triacylglycerols.
    • Desaturation of fatty acids. Metabolism of phospholipids. Metabolism of cholesterol and bile acids.
    • Replication, transcription.
    Literatura
      povinná literatura
    • Interactive Syllabus of the course in IS MUNI.
    • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017, viii, 567. ISBN 9781496363541. info
      doporučená literatura
    • KOOLMAN, Jan a Klaus-Heinrich RÖHM. Color atlas of biochemistry. 3rd ed., rev. and updated. Stuttgart: Thieme, 2013, ix, 495. ISBN 9783131003737. info
    • LIEBERMAN, Michael, Allan D. MARKS a Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 4th ed. Baltimore: Lippincott, Williams & Wilkins, 2013, ix, 1014. ISBN 9781451100037. info
    • VASUDEVAN, D. M., S. SREEKUMARI a Kannan VAIDYANATHAN. Textbook of biochemistry for dental students. 3rd edition. New Delhi: Jaypee, 2017, xiii, 289. ISBN 9789352701148. info
    Výukové metody
    Active work in seminars, problem solving, discussions.
    Metody hodnocení
    Credit. Conditions for giving the course-unit credit:
    1) completion of all seminars and 2) completion of in-term tests.
    Failure to meet the requirements of in-term tests requires a resit test, which may be repeated only once. All absences must be made up before a resit test.
    Detailed conditions are published in Study materials posted under the course/Interactive Syllabus.
    Vyučovací jazyk
    Angličtina
    Další komentáře
    Předmět je vyučován každoročně.
    Nachází se v prerekvizitách jiných předmětů
    Předmět je zařazen také v obdobích podzim 2020, podzim 2021, podzim 2022, podzim 2024.