aZLPF0521p Pathophysiology I - lecture

Lékařská fakulta
podzim 2023
Rozsah
2/0/0. 30. 1 kr. Ukončení: z.
Vyučující
prof. MUDr. Kateřina Kaňková, Ph.D. (přednášející)
prof. MUDr. Anna Vašků, CSc. (přednášející)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (přednášející)
prof. MUDr. Julie Dobrovolná, Ph.D. (přednášející)
doc. RNDr. Sabina Ševčíková, Ph.D. (přednášející)
MUDr. Jan Máchal, Ph.D. (přednášející)
Bc. Lenka Hladíková (pomocník)
Mgr. Katarína Chalásová, Ph.D. (pomocník)
Garance
prof. MUDr. Anna Vašků, CSc.
Ústav patologické fyziologie – Teoretická pracoviště – Lékařská fakulta
Kontaktní osoba: prof. MUDr. Anna Vašků, CSc.
Dodavatelské pracoviště: Ústav patologické fyziologie – Teoretická pracoviště – Lékařská fakulta
Rozvrh
Út 7. 11. až Pá 22. 12. Út 14:00–15:40 B22/116 aula, Po 18. 9. až Pá 20. 10. Út 14:00–15:40 B22/116 aula; a Út 24. 10. 14:00–15:40 A18/124, Út 31. 10. 14:00–15:40 B11/114
Předpoklady
aZLFY0422p Fyziologie II - přednáška && ( aZLBC041c Biochemie II - cvičení || aZLBC0422c Biochemie II - cvičení ) && ( aZLBC041s Biochemie II seminář || aZLBC0422s Biochemie II seminář )&& ( aZLAN0222s Anatomie II - sem. || aZLAN0333s Anatomie III - seminář ) && ( aZLAN0222c Anatomie II - pitvy || aZLAN0333c Anatomie III - pitvy ) && aZLHE0322c Histologie a embryol. II -cv. && aZLLT0222s Zákl. lék. terminologie II -s
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
Pathophysiology is a subject focusing on causes (aetiology) and mechanisms of disease development (pathogenesis) incl. changes inflicted by diseases on the level of the whole organism. Disease is usually (with exception of sudden events) a long terms process hidden (asymptomatic) for some time and only later and under certain circumstances might become clinically apparent illness. We aim to help the students to understand WHY and HOW are the changes unfolded. We also aspire to facilitate understanding disease etiopathogenesis complexly, i.e. from initial molecular and/or genetic alterations, via cellular, tissue and organ or event. systemic process. Pathophysiology represents an integrating discipline in medical curriculum bridging the theoretical/preclinical and clinical phase. Inextricably, despite the predominantly theoretical nature of the subject, we want to contribute to the building of the „evidence based medicine“ paradigm accompanied by the appreciation of the „precision medicine“ concept.
Výstupy z učení
General pathophysiology
Student characterizes state of healthy and disease
Student calls main sources of interindividual variability
Student demonstrates understanding of an influence of external factors on disease development, especially in oral cavity
Student characterizes base features of complex diseases
Student summarises importance of epigenetics
Student describes pathophysiology of stress reaction
Student defines homeostasis term
Student identifies disorder of growth and development from ontogenetic point of view
Student describes results of hypoxia including HIF 1 program
Student explains a difference between local and systemic inflammation
Student explains pathogenesis of oedema
Student discusses etiopathogenesis of the most important ion homeostasis disturbances, especially those of Ca++, Mg++ and K+
Student distinguishes base acid base balance disturbances and possibilities of their compensation
Student applies knowledge of volume and tonicity regulation
Student discusses a role of platelets and physiological endothelium during antiaggregation state and understands base principles of antiaggregation therapy
Student knows principles and performance of base coagulation tests
Student explains wound healing process with examples of pathological healing, especially in oral cavity
Student explains an importance of micronutrients abnormalities, especially considering oral cavity state
Student knows results of abnormal vitamin levels, especially in oral cavity
Student explains mechanism of genomic and non- genomic effects of soluble in lipids vitamins
Student discusses pathophysiology of protein metabolism
Student understands the base principles of regulation of glucose
Student interprets knowledge of immune recognition of own and foreign structure on examples of specifically organ and systemic disorders
Student interprets immunological knowledge of hypersensitive mechanisms in pathophysiology of atopic and allergic changes
Student describes onset, signs and results of heart and vessels remodelling
Student applies chronobiology knowledge for explication of different pathophysiological changes
Osnova
  • Detailed syllabus is provided in IS - Study materials - instructions
Literatura
    doporučená literatura
  • Pathophysiology of disease : an introduction to clinical medicine. Edited by Gary D. Hammer - Stephen J. McPhee. Eight edition. New York: McGraw-Hill Education, 2018, xiv, 814. ISBN 9781260288513. info
  • KUMAR, Vinay, Abul K. ABBAS a Jon C. ASTER. Robbins & Cotran pathologic basis of disease. Illustrated by James A. Perkins. Ninth edition. Philadelphia: Elsevier Saunders, 2015, xvi, 1391. ISBN 9780808924500. info
Výukové metody
Lecture.
Metody hodnocení
Pathophysiology course is finalised by an oral exam. Student will select questions from 4 different topics and he/she is given time to prepare answers (up to 120 min). Following topics will be represented by 1 question in oral exam: • A: circulatory, respiratory systems and kidney pathophysiology • B: gastrointestinal, endocrine, hematopoietic, musculoskeletal and nervous system pathophysiology • C: general pathophysiology • Study materials include practical tutorials, recommended literature and handouts provided for lectures.
Vyučovací jazyk
Angličtina
Informace učitele
http://www.med.muni.cz/patfyz
Lectures are scheduled at UCB Auditorium B22/116, Tuesdays 14-15.40
Další komentáře
Studijní materiály
Předmět je vyučován každý semestr.
Předmět je zařazen také v obdobích podzim 2017, podzim 2018, podzim 2019, podzim 2020, podzim 2021, podzim 2022, podzim 2024.