F1FT1_14 Pharmacology I

Faculty of Pharmacy
Spring 2020
Extent and Intensity
3/3/0. 7 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. PharmDr. Peter Kollár, Ph.D. (lecturer)
doc. RNDr. Eva Račanská, CSc. (lecturer)
MVDr. Renata Blechová, Ph.D. (seminar tutor)
MUDr. PharmDr. Marek Frydrych, Ph.D. (seminar tutor)
PharmDr. Bc. Kateřina Horská, Ph.D. (seminar tutor)
MUDr. Marta Chalupová, Ph.D. (seminar tutor)
PharmDr. Tereza Kauerová, Ph.D. (seminar tutor)
doc. PharmDr. Peter Kollár, Ph.D. (seminar tutor)
PharmDr. Bc. Hana Kotolová, Ph.D. (seminar tutor)
Guaranteed by
doc. PharmDr. Peter Kollár, Ph.D.
Department of Pharmacology and Toxicology – Departments – Faculty of Pharmacy
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Pharmacology is a science that studies interactions of medical substances and organisms on various morphological and physiological levels. It focuses on mechanisms and time progress of medicines in organisms (pharmacokinetics), and on medicines impact mechanisms on an organism (pharmacodynamics). Certain toxicology sections (science on toxins) constitute a part of the pharmacology in the area of undesirable effects as well.

Learning outcomes
After completing the course the student is able to clarify the basic general rules regarding the fate of the drug in the body and the mechanisms of the drug's effect on the human body. Student can also define and characterize the properties of specific drugs - mechanisms of action, pharmacological effects, pharmacokinetic properties, side effects and interactions. The student will be able to apply the acquired knowledge about the properties of drugs in a safe and effective pharmacotherapy.
Syllabus
  • Lectures:
    General pharmacology
    Pharmacokinetics
    ? Types of drug transport (translocation) in organism
    ? Absorption of drugs, influencing factors
    ? Distribution of drugs in organism, influencing factors
    ? Distribution - physiological barriers
    ? Metabolism of drugs, influencing factors
    ? Mechanisms of drugs excretion, influencing factors
    ? Basic pharmacokinetic parameters, calculation, practical significance in pharmacotherapy
    ? Factors influencing pharmacokinetics
    Pharmacodynamics
    ? Mechanisms of drugs action
    ? Quantitative (graded) and quantal (population) dose (concentration)- response relationships. Therapeutic index
    ? Drugs interactions
    ? Adverse and toxic effects of drugs
    ? Drug dependence, basic types
    ? Preclinical testing of drugs
    ? Clinical testing of drugs
    ? Pharmacology and human genome (pharmacogenomics, gene therapy)
    General toxicology of drugs
    Preclinical and clinical testing of drugs
    Special Pharmacology
    Pharmacology of the central nervous system
    ? Overview of neurotransmitters
    ? General anaesthetics
    ? Anxiolytic and hypnotic drugs
    ? Antipsychotic drugs
    ? Antidepressant drugs
    ? Antiepileptic drugs. Overview of centrally acting muscle relaxants
    ? Neurodegenerative disorders: Drugs in Parkinson´s disease, Alzheimer´s dementia
    ? Opioid analgesics
    ? CNS stimulants. Psychotomimetic agents (hallucinogens)
    ? Ethanol ? pharmacology, toxicology
    Pharmacology of the peripheral nervous system
    ? Autonomic nervous system ? muscarinic agonists (parasympathomimetics). Inhibitors of cholinesterase
    ? Autonomic nervous system ? muscarinic antagonists (parasympatholytics)
    ? Autonomic nervous system ? adrenoceptor agonists (sympathomimetics)
    ? Autonomic nervous system ? adrenoceptor antagonists (sympatholytics)
    ? Neuromuscular-blocking drugs
    ? Local anaesthetics
    Pharmacology of cardiovascular system
    ? Pharmacotherapy of chronic heart failure
    ? Antidysrhythmic drugs
    ? Pharmacotherapy of coronary heart disease: Therapy of angina pectoris. Overview of therapy of acute myocardial infarction
    ? Vasoactive drugs
    ? Inhibitors of angiotensin-converting enzyme. Antagonists of angiotensin receptors AT1
    ? Pharmacotherapy of arterial hypertension
    Atherosclerosis and lipoprotein metabolism
    ? Atherosclerosis ? risk factors, pharmacological and non-pharmacological prevention
    ? Pharmacotherapy of dyslipidaemias
    Pharmacology of the kidney
    ? Diuretics
Literature
    required literature
  • Švihovec Jan a kolektiv. Farmakologie. Grada, Praha, 2018. ISBN 978-80-247-5558-8. URL info
  • Martínková Jiřina a kolektiv. Farmakologie pro studenty zdravotnických oborů. Grada, Praha, 2018. ISBN 978-80-247-4157-4. URL info
  • Lüllmann H., Mohr K., Hein L. Barevný atlas farmakologie. Grada, Praha, 2012. ISBN 978-80-247-3908-3. URL info
    recommended literature
  • Whalen K. Lippincott Illustrated Reviews: Pharmacology, 7th edition. Lippincott Williams & Wilkins, USA, 2018. ISBN 978-1496384133. info
  • Humphrey P. Rang, Maureen M. Dale, James M. Ritter and Rod J. Fl. Rang & Dale's Pharmacology, 8th Edition. 2016. ISBN 978-0702053627. info
  • Trevor A, Katzung B, Masters S., Knuidering-Hall M. Katzung & Trevor's Pharmacology Examination and Board Review. McGraw-Hill Medical, 2012. ISBN 0071789235. info
  • Katzung BG. Basic and Clinical Pharmacology. McGraw-Hill Medical, 2011. ISBN 978-0071764018. info
  • Lincová Dagmar, Farghali, Hassan a kol. Základní a aplikovaná farmakologie. Galén, Praha, 2007. ISBN 9788072623730. info
  • Květina J. a kol. Farmakologie pro farmaceuty 2. díl. VFU Brno, 2003. info
  • Květina J. aa kol. Farmakologie pro farmaceuty 3. díl. VFU Brno, 2000. info
  • Květina J. a kol. Farmakologie pro farmaceuty 1. díl. VFU Brno, 1999. info
Teaching methods
lectures, seminars
Assessment methods
The criterion for passing the course is to obtain a credit. The condition for obtaining the credit is the fulfillment of attendance at seminars according to the rules below, which are also saved in the Study Materials of the course in the section Organizational Instructions, and successful completion of the credit test. Test questions will be prepared from the topics of the seminars. For test questions, the student always chooses one correct answer from the options offered, for which 1 point is added. No points will be deducted for an unfilled or incorrectly answered question. The condition for passing the credit test is to achieve at least 55% of the maximum possible number of points. Successful completion of the credit test is a condition for taking the Pharmacology II exam. An overview of questions for the Pharmacology II exam, which consists of General Pharmacology and Special Pharmacology, is given in the Study Materials of the course in the Teaching Materials section.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
Listed among pre-requisites of other courses
The course is also listed under the following terms Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2020, recent)
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