FaF:FDCME_FAF Molecular Biology - Course Information

FDCME_FAF Molecular Biology

Extent and Intensity

1/1/0. 25 credit(s). Type of Completion: zk (examination).

Guaranteed by

Mgr. Marie Brázdová, Ph.D.
Faculty of Pharmacy

Prerequisites

The subject is realized through consultations and self-study, assumes the mastering of the study literature and the understanding of the context.

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• Medicinal Chemistry (programme FaF, D-FCH) (2)

Course objectives

Molecular biology for DSP as a discipline which aims to study cellular biological processes at their molecular level. Learning outcomes of the course unit aim to acquaint the student with current trends and methods, especially for testing the bioactivity of natural substances at the molecular level.

Syllabus

• 1) Molecular biology and its position in biological sciences, milestones, personalities, central dogma of molecular biology
  2) Information macromolecules, their structure, function and interaction in gene expression, genetic code.
  3) Structure of prokaryotic genome, replication and gene expression in prokaryotes.
  4) Structure of eukaryotic genome, replication and gene expression in eukaryotes.
  5) Regulation of gene expression, molecular signalling.
  6) RNA interference
  7) Molecular biology of viruses, replication, expression of bacterial and animal virus's genes.
  8) Mutagenesis, spontaneous and induced mutation and reversion.
  9) Molecular basis of recombination, recombinantion in genetics.
  10) Transposons, mechanisms of transposition, retroelements, retroviruses.
  11) Reparation and excision mechanisms.
  12) Molecular basis of cancerogenesis, protooncogenes and oncogenes, suppressor genes, oncoviruses.
  13) Cell cycle and apoptosis
  

Literature

required literature
• D. Peter Snustad Michael J. Simmons. Genetika. Brno, 2017. ISBN 9788021086135. info
• BARTOŠ, M., BARTOŠOVÁ, L. Základy molekulární biologie pro farmaceuty. FaF VFU Brno, 2006. info
• ROSYPAL, S. et al. Úvod do molekulární biologie. Vydavatel prof. RNDR. Stanislav Rosypal, DrSc. B, 2002. info

not specified
• RUSSELL, P.J. iGenetics, A molecular Approach. Pearson, Benjamin Cummings. New York, U.S.A., 2006. info
• WATSON, D.J. et al. Molecular biology of the gene. Cold Spring Harbor Laboratory Press, Pearson, Be, 2004. info
• ROSYPAL, S. et al. Terminologie molekulární biologie. Vydavatel prof. RNDr. Stanislav Rosypal, DrSc.,, 2001. info

Teaching methods (in Czech)

Metody práce s textem (učebnicí, knihou)

Assessment methods (in Czech)

Ústní zkouška
Písemná zkouška

Language of instruction

Czech

Further comments (probably available only in Czech)

The course can also be completed outside the examination period.

Teacher's information

Requirements for the student
Successful completion of the subject by written and oral examination. The mark is based mainly on the part of the test. To pass the course, you must pass the test at 60%.

• Enrolment Statistics (Spring 2020, recent)
  
• Permalink: https://is.muni.cz/course/pharm/spring2020/FDCME_FAF