C9909 Elements of fine process chemistry

Přírodovědecká fakulta
jaro 2025
Rozsah
2/0/0. 2 kr. (plus ukončení). Ukončení: zk.
Vyučující
RNDr. Petr Beňovský, Ph.D. (přednášející)
Garance
doc. RNDr. Ctibor Mazal, CSc.
Ústav chemie – Chemická sekce – Přírodovědecká fakulta
Předpoklady
Basic knowledge of organic chemistry, organic synthesis, physical chemistry
Omezení zápisu do předmětu
Předmět je otevřen studentům libovolného oboru.
Cíle předmětu
This lecture should provide much broader information about practical aspects of process chemistry that is very important in the real professional life in process chemistry companies.
Výstupy z učení
After successful completion of the lecture (passing the exam) a student should be able to understand factors that apply on different scales of a chemical process. A student should be able to independently decide which reaction system is suitable for a purpose, should be able to distinguish among several options and select the best one. A student is trained to apply theoretical knowledge and understand its impact to the outcome of the chemical reaction.
Osnova
  • Outline of the class; History of fine process chemistry, recent trends, future; Differences between laboratory and larger scale experiments; Scale-up/downscale considerations; Safety; Crystallization (solubility, metastable zone, nucleation, crystal growth, optical resolution, Viedma ripening, attrition enhanced deracemization, seeding, Ostwald ripening, new trends in crystallization); Polymorphism; Typical process operations (mixing, heat transfer, agglomeration, product isolation, distillation, drying, purification, work up, reactors); Continuous manufacturing, flow chemistry; Synthetic route selection; Analytical methods, Process Analytical Technology (PAT), Design of Experiments (DoE), Quality by Design (QbD); Environmental Aspects; Economy, Cost of Goods (CoG); Regulatory issues, patents. Copious example from recent literature about various topics within the whole lecture.
Literatura
  • Neal Anderson, Practical Process Research & Development, Elsevier, 2nd Ed. 2012
Výukové metody
Lectures
Metody hodnocení
Final written test
Vyučovací jazyk
Angličtina
Další komentáře
Předmět je vyučován jednou za dva roky.
Předmět je zařazen také v obdobích jaro 2020, jaro 2021, jaro 2022, jaro 2023.