C8635 Genetic Ecotoxicology

Faculty of Science
Spring 2002
Extent and Intensity
2/0/0. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
RNDr. Ing. Karel Chroust, Ph.D. (lecturer)
Guaranteed by
RNDr. Ing. Karel Chroust, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: RNDr. Ing. Karel Chroust, Ph.D.
Prerequisites (in Czech)
( Ex_3162 Obecná genetika || Imp_9126 Obecná genetika || B1900 Basic genetics || BMB32 Basic genetics || B6730 Basic genetics || B8470 Genetics || B3060 Basic genetics ) && ( Ex_3065 Molekulární biologie || Imp_9115 Molekulární biologie || B4030 Molecular biology || B3120 Molecular and cell biology || B5740 Molecular biology || B7940 Molecular biology || B6130 Molecular biology || B4020 Molecular biology )
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Genetic ecotoxicology as a science. Ecotoxicology and genetic toxicology. Genetic toxicology, mutagenesis in organisms and populations. Spontaneous and induced mutations. Gene mutations, chromosomal abberations, aneuploidy and polyploidy. Risk factors identification, models, acute and chronical exposition. Gametic and somatic mutations. DNA repairs, recombinations. In vivo and in vitro assays, procaryotic and eucaryotic organisms. Gametic and somatic assays, metabolic activation, transgenic systems. Choice of laboratory and in situ genotoxicity tests. Batery of tests, predictive value. Molecular analysis of mutations. Monitoring of human population, epidemiological and clinical study. Legislative and recommendations in the Czech Republic and EC.
Syllabus
  • 1. Introduction to the genetic ecotoxicology, principles of ecotoxicology and genetics toxicology. 2. Genetics toxicology, damages of DNA in living organisms and populations. The spontaneous and induced mutations. 3. Kinds of genetic damages, gene mutations, chromosomal aberrations, aneuploidy and polyploidy. 4. Genetics risks assessment and model estimations. Acute and chronical expose. 5. Health impact of mutations for living oraganisms and human health. Mutations i germ and somatic cells. DNA repair, recombinagenic effects. 6. Mutagenicity assays in vivo and in vitro. Prokaryotic and eukaryotic organisms in genetics toxicology. 7. Mutagenic assays in germ and somatic cells. Metabolic activation. Transgenic systems 8. Mutagenic assays in laboratory and field experiments. 9. Battery of genotoxicity tests. Predictive power of mutagenicity assays. 10. Molecular analysis of mutations. 11. Monitoring of human populations. Epidemiological and clinical study. 12. Recommendation and laws of genotoxicological testing in Czech and EC.
Literature
  • MORIARTY, F. Ecotoxicology : the study of pollutants in ecosystems. 3rd ed. San Diego: Academic Press, 1999, x, 347. ISBN 0125067631. info
  • PIEGORSCH, Walter W. and John A. BAILER. Statistics for environmental biology and toxicology. 1st ed. London: Chapman & Hall, 1997, xvi, 579. ISBN 0412047314. info
  • HOFFMAN, D.J. and B.A. RATTNER. Handbook of Ecotoxicology. Boca Raton, FL, USA: CRC Press, 1994. info
  • Toxicology of chemical mixtures : case studies, mechanisms, and novel approaches. Edited by Raymond S. H. Yang. San Diego: Academic Press, 1994, 720 s. ISBN 0-12-768350-X. info
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Spring 2000, Spring 2001.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/sci/spring2002/C8635