PřF:C2200 Chemical synthesis - lab. - Course Information

C2200 Chemical synthesis - laboratory course

Extent and Intensity

0/0/6. 6 credit(s). Type of Completion: z (credit).

Teacher(s)

RNDr. Miloš Černík, CSc. (seminar tutor)
doc. Mgr. Marek Nečas, Ph.D. (seminar tutor)
doc. RNDr. Josef Novosad, CSc. (seminar tutor)
Ing. Alena Pálková (seminar tutor)
prof. RNDr. Jiří Pinkas, Ph.D. (seminar tutor)
prof. Ing. Vladimír Šindelář, Ph.D. (seminar tutor)

Guaranteed by

prof. Ing. Vladimír Šindelář, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science

Prerequisites

Basic knowledge of general, inorganic and organic chemistry. Writing chemical equations, stoichiometric calculations, and calculations of solution concentration and mixing will be used extensively.

Course Enrolment Limitations

The course is offered to students of any study field.

Course objectives

Basic laboratory course in preparative chemistry. Covers syntheses, properties and structures of simple inorganic and organic compounds, such as oxides, halides and other salts, acids and their functional derivatives, and complexes. At the end of the course students should be able to explain the principles that underpin selected synthetic processes, and why specialist techniques are required for their preparation.

Syllabus

• 1. Introduction, safety rules, laboratory notebook, worked example of experiment calculations. Requirements for passing the course. Nomenclature of inorganic and organic compounds. Chemical literature.
  2. Ethyl 3-oxobutanoate ethylenacetale. AN mechanism to C=O, azeotropic and vacuum distillation, work with rotary evaporator.
  3. Synthetic routes to salts. Copper(II) sulfate. Copper(I) iodide. Mohr's salt.
  4. Synthetic routes to acids and halides. Orthoboric acid. Tin(IV) iodide.
  5. 4,4-diphenyl-4-hydroxy-2-butanone ethylenacetale. Extraction, work with rotary evaporator, recrystallization.
  6. Synthetic routes to coordination compounds. Hexaaquacobalt(II) chloride.
  7. Hexaamminecobalt(III) chloride. Pentaammine-chlorocobalt(III) chloride. Potassium tetraperoxochromate(V).
  8. Synthetic routes to salts. Metal acetylacetonate complexes. Thin-layer chromatography.
  9. 3-Nitroacetophenone. SEAr mechanism, recrystallization, IR spectroscopy.
  10. Benzoic acid. AN to C=O, work with anhydrous solvents, extraction, sublimation.
  11. Synthetic routes to oxides. Boric oxide. Trimethylborate. Amonnium tetrathiomolybdate(VI).
  12. Ethyl-acetate. Esterifikace, distillation.
  13. 2-Hydroxy-5-methyl-2'-nitroazobenzene. Diazotization and diazonium coupling, recrystallization, TLC.
  14. Final test, make-up class, lab cleaning.

Literature

• Masarykova univerzita. Přírodovědecká fakulta. Návody ke cvičení z anorganické chemie. Brno, Masarykova univerzita, 2006, 80 s.
• NOVÁČEK, Eduard and Milan POTÁČEK. Laboratorní technika ke cvičení z metod organické chemie. Edited by Slávka Janků. 1. vyd. Brno: Masarykova univerzita, 1997, 91 s. ISBN 8021015004. info
• KLIKORKA, Jiří. Úvod do preparativní anorganické chemie. 3. vyd. Praha: SNTL - Nakladatelství technické literatury, 1974, 373 s. info
• TANAKA, John and Steven L. SUIB. Experimental Methods in Inorganic Chemistry. New Jersey: Prentice Hall, 1999, 393 pp. ISBN 0-13-841909-4. info

Assessment methods

The course can also be completed outside the examination period. The course is taught annually. The course is taught: every week.

Language of instruction

Czech

Further comments (probably available only in Czech)

The course is taught annually.
The course is taught: every week.
General note: Vyučují učitelé Ústavu chemie.

Listed among pre-requisites of other courses

• C2720 Organic Chemistry - laboratory course
  (C4221||C1100||C1600)&&!C2200  
• C6190 Advanced laboratory course of inorganic chemistry.
  C2200  

• Enrolment Statistics (Spring 2008 - for the purpose of the accreditation, recent)
  
• Permalink: https://is.muni.cz/course/sci/spring2008-forthepurposeoftheaccreditation/C2200