Bi8099 Fundamentals of antimicrobial therapy

Faculty of Science
Spring 2009
Extent and Intensity
2/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
Teacher(s)
Mgr. Lucie Pokludová, Ph.D. (lecturer), doc. RNDr. Miroslav Němec, CSc. (deputy)
Guaranteed by
prof. RNDr. Zdeněk Hubálek, DrSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: doc. RNDr. Miroslav Němec, CSc.
Timetable
Tue 8:00–9:50 Bpt,01013
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
This lecture is intended for the students of microbiology and related specialisations. The summary of history of chemotherapy and the use of antimicrobials is mentioned at the beginning of the lecture. The human medicine and veterinary medicine aspects, explanation of the principles of antimicrobial policy and trends in assessments of quality, safety and efficacy of medicinal products containing antimcrobial substances are included in general parts of the lecture both from the European and world point of view. Mechanisms of action, mechanisms of resistance and genetical aspects of resistance to antimicrobial substances are included in specialised parts. The methods of susceptibility and resistance tests in routine microbiological laboratories together with the performance of the test for specific fenotypes and markers of resistance are provided. The survey of antimicrobial substances according to the pharmacological classes with detail description of chemical, microbiological and therapeutical characteristics is explained. Treatments of infection diseases with medicinal product containing antimicrobials are described. Recent information on the development of the new human and veterinary antimicrobials, the references to the current bibliography, publications and available web pages related to the antimicrobials are provided. Possibility of use of information included in this lecture in the scope of diagnostic microbiology, pharmaceutical microbiology, pharmacy, therapy of infection diseases and legal provisions related to antimicrobials.
Syllabus
  • The history of the chemotherapy and use of antibiotics The mechanisms of efficacy of antimicrobial substances The resistance to antimicrobials mechanisms The resistance to antimicrobials genetics and resistance transfers The resistance from the aspect of therapy in human medicine communities and hospitals The resistance from the aspect of therapy in veterinary medicine The laboratory checking of the antimicrobial therapy Specifics of laboratory checking regarding to the species of microorganisms The survey of antimicrobials according to pharmacologic groups and aspects of use of antimicrobial products in human and veterinary medicine The principles of antimicrobial therapy, specific of pregnant women and children use of antibiotics The human antibiotic health care policy in the Czech Republic The veterinary health care strategy in the Czech Republic Adverse reactions in use of antimicrobial drugs The development of new antimicrobials, marketing authorization of medicinale products for human and veterinary use Aspects of checking of veterinary antimicrobials
Literature
  • 6. White, D.G., Alekshun, M.N., McDermott, P.F. (2005): Frontiers in Antimicrobial resistance, ASM Press, Washington, D.C., 570 s.
  • Antibiotika vsoučasné lékařské praxi C.Simon, W Stille, Grada Publishing, 1998
  • Antibiotika, sulfonamidy a chinolony ve veterinární medicíně, J. Šimůnek,J.Smola, LAST, 1998
  • 5. Šimůnek, J., Smola, J. (2007): Antimikrobiální léčiva ve veterinární medicíně, Prion, 251s
  • 1. Aarestrup, F.M. (ed.), (2006) Antimicrobial resistance in bacteria of animal origin. , ASM Press, Washington, D.C., 442 s.
Assessment methods
lectures,oral or written exam
Language of instruction
Czech
The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, spring 2018, Spring 2019, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2009, recent)
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