C5241 Analysis of Organic Compounds I

Faculty of Science
Autumn 2002
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Miloš Bartušek, CSc. (lecturer)
doc. RNDr. Bc. Jiří Pazourek, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Miloš Bartušek, CSc.
Chemistry Section – Faculty of Science
Prerequisites
C2021 - Organic chemistry I C3100 + C4050 Analytical chemistry (at least C1660)
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 10 fields of study the course is directly associated with, display
Course objectives
Classical organic analysis = characteristic physical properties of organic compounds, elemental analysis of organic compounds, analytical identification and determination of important functional groups of organic compounds, mainly by colour reactions in solution. Interpretation of spectra of simple organic compounds obtained by instrumental methods: UV-VIS, IR, NMR, MS.
Syllabus
  • Characteristics of analysis of organic compounds. The methodology of the analysis, development and trends. Determination of physical constants: melting and boiling point, refractivity, optical activity, partition coefficients of extraction, molecular weight, spectral constants. Elemental analysis. Sample decomposition, detection and determination of C, H, O, N, Cl, Br, I, S, P, F. Automatic methods of elemental analysis. Functional groups identification: classes of dissolution, classification reactions for carbohydrates, alcohols, phenols, aldehydes, ketons, carboxylic acids, acid anhydrides, esters, amides, imides, ethers, epoxides, peroxides, amines, nitriles, isonitriles, nitro-, nitroso-, azo-, azoxy-, hydrazo- and diazo- compounds, thiols, sulphonic and sulphinic acids, halogenic compounds. Determination of organic compounds based on their functional groups reactions. Determination of active hydrogen, determination of hydroxy-, carbonyl-, carboxyl-, amino-, nitro-, nitroso-, thio- a halogeno-compounds. Liquid-liquid extraction, thin layer chromatography (TLC). Instrumental methods of organic analysis - principles (gas chromatography (GC), liquid chromatography (LC), spectroscopy, optical rotation dispersion (ORD), nuclear magnetic resonance (NMR) and mass spectrometry (MS)). Spectra interpretation in organic analysis UV-VIS spectroscopy: sigma and pi orbitals, chromophores, allowed and disallowed electron transitions, Woodward-Fieser rules, examples. Infra red (IR) spectroscopy: models of fundamental and normal vibration, procedure of IR spectra interpretation with tables of characteristic vibrations. Nuclear magnetic resonance (NMR): chemical shift, first order spectra and their interpretation, spin interaction constant, decoupling, examples. Mass spectrometry (MS): specifics of the spectra, determination of summary formula from the natural nuclides distribution, fragments analysis of organic molecules, ionradical, molecular ion, empirical rules, carbcation stability, nitrogen rules, examples.
Literature
  • STRÁNSKÝ, Zdeněk. Analýza organických sloučenin. 1. vyd. Olomouc: Univerzita Palackého, 1981, 235 s. info
  • STRÁNSKÝ, Zdeněk. Analýza organických sloučenin b. 1. vyd. Olomouc: Univerzita Palackého, 1981, 235 s. info
  • KALOUS, Vítěz. Jak moderní chemie zkoumá strukturu molekul. 1. vyd. Praha: SNTL - Nakladatelství technické literatury, 1983, 150 s. URL info
  • HOLZBECHER, Záviš. Analytická chemie. 2., přeprac. vyd. Praha: SNTL - Nakladatelství technické literatury, 1974, 506 s. info
  • STUŽKA, Václav. Instrumentální metody chemické analysy. 1. vyd. Olomouc: Univerzita Palackého, 1974, 111 s. info
  • STUŽKA, Václav. Instrumentální metody chemické analysy. 1. vyd. Olomouc: Univerzita Palackého, 1975, 128 s. info
  • STUŽKA, Václav. Instrumentální metody chemické analýzy. 1. vyd. Olomouc: Univerzita Palackého, 1976, 146 s. info
Assessment methods (in Czech)
přednáška zkouška
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
Teacher's information
http://www.chemi.muni.cz/~pazourek/
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021, Autumn 2022, Autumn 2023, Autumn 2024.
  • Enrolment Statistics (Autumn 2002, recent)
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