C3060 Organic Chemistry - laboratory course

Faculty of Science
Autumn 2011
Extent and Intensity
0/0/7. 7 credit(s). Recommended Type of Completion: graded credit. Other types of completion: z (credit).
Teacher(s)
RNDr. Slávka Janků, Ph.D. (seminar tutor)
prof. RNDr. Milan Potáček, CSc. (lecturer)
Mgr. Zdeněk Moravec, Ph.D. (assistant)
Guaranteed by
RNDr. Slávka Janků, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: RNDr. Slávka Janků, Ph.D.
Timetable of Seminar Groups
C3060/01: Tue 7:00–13:50 C10/109, S. Janků
C3060/02: Thu 7:00–13:50 C10/109, S. Janků
Prerequisites
NOW( C7777 Handling chemicals )&&(! C2200 Chemical synthesis - lab. )
C1080; You have to pass tests of your knowledge.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
The capacity limit for the course is 66 student(s).
Current registration and enrolment status: enrolled: 0/66, only registered: 0/66, only registered with preference (fields directly associated with the programme): 0/66
fields of study / plans the course is directly associated with
Course objectives
Fundamental laboratory methods of organic chemistry for synthesis (heating, stirring, cooling, introduction of gases, working with decrease of pressure, drying) and separation of organic compounds (filtering, crystallization, distillation, extraction). The methods are trained an the compounds synthesis of important types of organic reactions. The products are characterized by melting point, thin-layer chromathography, refractive index, and infra-red spectroscopy. The aim of the course is to teach students the basic methods of laboratory technique of organic chemistry with the aim to bring them to knowledge to synthesize compounds according with the literature information.
Syllabus
  • 1. a) Ethyl bromide (SN2 mechanism, distillation) b) tert-Butyl chloride (SN1 mechanism, distillation) 2. 3-Phenylpropanoic acid (Catalytic hydrogenation, work with hydrogen, recrystallization, work with rotary evaporator) 3. Phenole nitration(SEAr mechanism , steam distillation , recrystallization) 4. Azobenzene (electrochemical reduction, recrystallization, TLC) 5. Ethyl 3-oxobutanoate ethylenacetale(AN mechanism to C=O, azeotropic and vacuum distillation, work with rotary evaporator) 6. a) 4,4-diphenyl-4-hydroxy-2-butanone ethylenacetale (AN mechanism to C=O, extraction, work with rotary evaporator, recrystallization) b) 4,4-Diphenyl-4-hydroxy-2-butanone (acid catalyzed hydrolysis of acetale, extraction, work with rotary evaporator, recrystallization) 7. 3-Nitroacetophenone (SEAr mechanism , recrystallization, IR spectroscopy) 8. a) 1-(3-Nitrophenyl)ethanol (selective reduction, extraction, recrystallization, IR spectroscopy) b) 3-Aminoacetophenone (selective reduction, recrystallization, IR spectroscopy) 9. Pinacol (metal reduction in anhydrous non-polar solvents, work with rotary evaporator) 10. Benzoic acid(AN to C=O, work with anhydrous solvents, extraction, sublimation) 11. Anthranilic acid (Hofmannovo odbourávání amide, recrystallization) 12. Ethyl-acetate (esterifikace, distillation) 13. 2-Hydroxy-5-methyl-2'-nitroazobenzene (diazotization and diazonium coupling, recrystallization, TLC) 14. 2-(2-Hydroxy-5-methylfenyl)benzotriazol (biochemical reductive cyclization, extraction, work with rotary evaporator, recrystallization) 15. 2-chlorbenzoic acide (diazotisation a Sandmayer reakction, recrystallization) Every student have to pass at least 14 practices. Practice 3, 5, 6, 7, 10 a 15 are required
Literature
  • NOVÁČEK, Eduard and Milan POTÁČEK. Laboratorní technika ke cvičení z metod organické chemie. Edited by Slávka Janků. 1. vyd. Brno: Masarykova univerzita, 1997, 91 s. ISBN 8021015004. info
Teaching methods
laboratory exercises
Assessment methods
Preparation for the ability to enter laboratory before every laboratory course is tested by computer managed tests on methods of laboratory technique, knowledge of reaction mechanism as well as safety regulations connected with the certain synthesis. The course is closed by graded credits.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
General note: Vyučují učitelé katedry organické chemie.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011 - acreditation.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2011/C3060