PřF:C5920 Good Laboratory Practice - Course Information

C5920 Good Laboratory Practice

Extent and Intensity

1/0/0. 1 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

Mgr. Bc. Lucie Bielská, Ph.D. (lecturer)
prof. RNDr. Luděk Bláha, Ph.D. (lecturer)
doc. Ing. Branislav Vrana, PhD. (lecturer)

Guaranteed by

prof. RNDr. Ivan Holoubek, CSc.
RECETOX – Faculty of Science
Contact Person: prof. RNDr. Jana Klánová, Ph.D.
Supplier department: RECETOX – Faculty of Science

Timetable

Fri 14:00–15:50 D29/252-RCX1

Prerequisites

! C3705 Good laboratory practice in chemical laboratory
Introductory course on Analytical Chemistry or an equivalent, basic knowledge in biology.

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• Analytical Biochemistry (Eng.) (programme PřF, N-BCH)
• Analytical Chemistry (programme PřF, N-CH)
• Environmental Chemistry (programme PřF, N-CH)
• Special Biology (programme PřF, N-EXB)
• Special Biology (programme PřF, N-EXB, specialization Ekotoxikologie)

Course objectives

At the end of the course, students will be able to:;
- understand major principle assuring quality of the analytical results both in chemistry and biology. ;
- discuss goals of GLP, fundamental terms and standards. ;
- describe, discuss and interpret organisation of laboratory and work conditions, laboratory accreditation and proficiency testing. ;
- conduct equipment validation, validation of analytical system. ;
- apply fundamentals of good sampling practice including techniques for homogeneous and nonhomogeneous objects, design and evaluation of sampling plan with emphasis on environmental sampling. ;
- understand needs of GLP application in practices (e.g. in biology such as safety assessment of chemicals for humans and the environment, microbiology and biochemistry, GMO etc.)

Syllabus

• I. GLP principles and goals. Historical background, quality assurance and quality management. II. Key provisions. Organisation of laboratory, conditions. III. Laboratory accreditation. ČSN EN ISO/IEC 17025 Standard, terminology. IV. Proficiency testing. Methodology. V. Validation and testing. Validation of equipment, method, analytical system, and data. VI. Validation of analytical methods. VII. Estimation of performance characteristics. Documentation of an analytical method. VIII. Evaluation of results in respect to limit values. Control charts. IX. Principles of good sampling practice. Homogenous and heterogeneous objects, randomized and segregated objects. Sampling errors and sampling plan. X. Sampling techniques. Homogeneity test. Sampling of nonhomogenous objects. Assurance of sampling randomness. Systematic sampling of nonhomogenous materials. XI. Design and evaluation of a sampling plan. Evaluation of sampling precision and correctness. Documentation of sampling. XII. Environmental sampling.

Literature

• CROSBY, N. T. and F. E. PRICHARD. Quality in the Analytical Laboratory. Chichester: J. Wiley, 1995. Analytical Chemistry by Open Learning (Series). ISBN 0 471 95470 5. info
• MESTEK, O. and L. NONDEK. Zásady správného odběru vzorků pro analýzu životního prostředí (Principles of Good Sampling Practice in Environmental Analysis). Praha: Eurachem - ČR, 1995. Kvalimetrie, 4. ISBN 80-901868-0-7. info

Teaching methods

lectures (weekly)

Assessment methods

Students are evaluated by a written test(30 open questions, 50% success is required as minimum for further evaluation - 15-30 points are reflected in final result E-A).

Language of instruction

Czech

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.

Listed among pre-requisites of other courses

• C3705 Good laboratory practice in chemical laboratory
  !C3700 && !C5920  

Teacher's information

http://www.recetox.muni.cz

• Enrolment Statistics (Autumn 2014, recent)
  
• Permalink: https://is.muni.cz/course/sci/autumn2014/C5920